{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022X8V3oonZN19gzHSxUNwaQxn+fCCH3O5xs+1yqNklRMfxkbnxaW467tvhgOLQsndXXQGExcn+vHCsmjpMTTd+3BmePz8ecaWTj+PL7feIlmQRjJjqJ21rvjjYNz6ZoU\\\\\\\\\\\\\\\/WN2xc7nsdFHZSMPx\\\\\\\\\\\\\\\/MKWZAyXc6qj4lSRSIirfqCIZE1mSAtdlpB1aD0\\\\\\\\\\\\\\\/xxB+U1GvAtDxF3nEmwg4j4iv5bchVhk0b2rKgXMT+TEawgNMGiep0zycoNPQWq1Yjta60FkNjtfV4aUgQ1bBFe4ctkYxtQLSpPogY9\\\\\\\\\\\\\\\/FBhilZUW7hCb1dCnkw\\\\\\\\\\\\\\\/K77bgGH5QlXGlGdTN1N4MmDyfSfSZOpLQzG+qxxgFfmSe2PX++cVl4xyE8hH+1wxkzuycgasf6DCdyDKp7oZJTfcK9RnL+nVgm5OLddBHRzBUz5cDeMh0hzKAJ6tl7zdinNJV8XAYPmiITaCmcVHs82lXQ4FT6hi7fl2On4\\\\\\\\\\\\\\\/d50vIV7\\\\\\\\\\\\\\\/4Y6X1HEzjOegXNXJsOJoHbwF\\\\\\\\\\\\\\\/WF34gCxv5VIaaOjVVxff96zNxUSt3thC0LwSw7sT\\\\\\\\\\\\\\\/Wt3OB+\\\\\\\\\\\\\\\/01PeWPATulsLSMeG5KIj\\\\\\\\\\\\\\\/WZse3FGBH\\\\\\\\\\\\\\\/A3+386Q33DoJwQExYSmstDFq3R1fwDSaFzoqMd1u3kFAkbqjz45pQjf3klVq9m\\\\\\\\\\\\\\\/5UOw09mKy1MYJcOVeJTOrFe1K9vT7xtoinA9umcHzqxbdx2rPZ1eh8Y5Z0ijhBDV5zkl4FXz7sCwkPQtqDSHFhI0weCBB4l0rlYThmmUPd0akxdGTo33K3bTwm2k+MtkT2A4Lp04J0xPf0djoP7mYly0GQ1QTf1KcsYrZOjXTJcKvKqhL4QvqDhOJqm9VWs+IkUAxvR4vwxVU1zrYFCP3grRAM1xcZoknoyyr7UuF5zDKDhB8sORqMjqCx08dFr4tVTTu3HtQMneDbEu+WD0PyaTkwOyA0THTtEb59suhJnCQ\\\\\\\\\\\\\\\/ciuOg03tstqK9jRM\\\\\\\\\\\\\\\/H7n49HtM0hef3qbDmx41YFE9kuvmePZKugYOu4YG2oVk0uNYF3RFBlmCgzTDosG9N15Q1bcAuMRv0W9p26nbDfC0TQnkX19MAA+wkI\\\\\\\\\\\\\\\/JXM9MsyiBPikS\\\\\\\\\\\\\\\/g3RQ2GUDkeeOjvS5QsbEkq1q5OB7EmhV3ci8eUeS3zAaWV4pqE87pxbiPvXgRQp6BdRNVRhpjSmNqk2diIVNxV\\\\\\\\\\\\\\\/oAsxpAdU5E7LPq3HaJ92XEhGOlFlBPpkiQwqcQ0BSBrOZ6XoLOSXhSNaBWFyrtYWntA52KkzSiUe8ATD2Mn9R1NgdubTF5vv4ujmBrjcTlBsgpLQoiBvPkAFZNCgCdHCYC2FjRHZYocrQahMk553L6p4tYCSEGSJ6baCgjTsrzd6Qt42x3Z3vIj6PxE29sGkUipJQX50G3n8gDAdbpz3bE+QvivWOaevYjSVY3rJXu1IFIPYih\\\\\\\\\\\\\\\/ztjl6b1JnjbKdD+2ZTeJpG99VsQZiqIA6yaSbIE9mdDGxqQezu1iPi3VVAuBjg1CfNnwN1RkeU5kG9ejjE396oRwXbQfsSKaVTzQNohQo03q7cjAesNEORRPlvdzL5Px7Vx9exdQkJM7iqHl53dozFoQEH19wGzEDsa0L3HFQU1XNyZNSaKO341F4akBp480KTsgIhLKdjN5ZmzR6mY9FWpqVcfS7HMksrSkKl5MH5K95p3Lyef0tQcywBqSYaPs5jMrshE0TwirfGVXg80ftet4RmvUR0SM45JC36iePZ2zSGPjy3e3B1683K9PMNtdj41QmoQ49hBi1Qpk2YEMbF\\\\\\\\\\\\\\\/OKdHrsDHFjr0tNbNSuUtiYoEKFBkIKFAV4lrqm5ReABqWYLvN\\\\\\\\\\\\\\\/rx9boe1Q+yt\\\\\\\\\\\\\\\/DRg9Mx13RvqO6IVfGkM\\\\\\\\\\\\\\\/S7Os3axqfKHlU+VBM6E74oItvrig7j3rSizdeLFCe+LLbU7v7sZqQEJ6NXPGBGOMxBhJY+4A\\\\\\\\\\\\\\\/QlNvDyRQU5TdexWR9MlwgPtvq2l93liPHPvnqe48hmcm4uklcefN9cx3uYL+9rTJnVS8iqkK0zDlcy5ePREaBTOl6snkC+q5wXqa4Mhnp58PKhib2ArY0YCnWUk129K6dvMYTWBw17JIqhR5AuQJ2zW+WQ4FGMpKdzK7x7q2UvFlLWt5QA3nhYXYj+i80XY5W3TtzMRDcEHCICrNh7GYeO5ExscDVWKZdQKhNSTJI9cnln60oygqUHimP9TQB7p7yRsJ9a5KnZsi6uWoJIkNOW1HSFxUWuogEVjHuYnDMDfQB9SRbJkh9Pw46\\\\\\\\\\\\\\\/bMRJ4gFVwAQVfSbbF+7ejI88TGEODGFlbdZ9HMvX5YC89fo9rm1NYIS48MbyAy0bnfXHby1lCDdJRUi5WrP+LCt+GydzpoaAix0TANoP7b8OqaBaY6UiXgCdTpsIVHGqujixTqbKIbHGQOK7iiSxSGMq3\\\\\\\\\\\\\\\/Ypu191ckO+KyWhIFWdU2GiU5ksneX1Jnk5rLx8oB2AzMfwLcKwO4uQ7t+xli9LMVDHZPQaogTs+qQlr69rOug6OZY8DuNBKsmKZC3XclHpP0Nkva1SO90d1HiDpxjoRNSgfcIXymazlXdFpBAbHzGARA9ebJQZrcFN1W77M+DEhR3uZov6Ng9MBRPCRCHX\\\\\\\\\\\\\\\/Txcu2ZmNyIiL1XA\\\\\\\\\\\\\\\/MSap\\\\\\\\\\\\\\\/QrIJYy+bSfQ=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00223FSNeO02G8lMu2msAlrYLg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022e662e71fbfb31c707224de858bc498ff568d10aac364d321c9fa6806048478b8\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/82.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/82.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0396-9\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0396-9\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0396-9\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}