{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022gh92zFEeVsuoodlTtrO5+XAMIqS56z++jcCl6uUP1JHjQvBkECqs5MChNctJzVww3yFjrRDX9cLl7XmFzGlqsu2AXBaX5fleAor1qJ45NjNhason6zChFHL8mzUbG7Rp8of\\\\\\\\\\\\\\\/WoHlybv1f6f3lrVZ92jULpAsqx9Vzryk5JJSQGIsQjPv+9JC5a9UahoW9Qjj\\\\\\\\\\\\\\\/QiKyFckZrddmSYPVVkXEF7Csu3jdqNgaXQ10CcZaRGV79we5ALs1c7kMc1R3zhNEgL3J57Jk4OfLCY42V\\\\\\\\\\\\\\\/zpL+e4dM38xwwpEvayReKilqsH2sAgG7g6LuXLGrEVxTDEwhOlBzt58IenGdQlFNOc\\\\\\\\\\\\\\\/ng2KW+8A6z4sPgngb6yeAY18vZEpw6+uxkUyNbzlbxGT4IxHF0K25eBvuIZG0WmhMXQzzvPfuk9pYP0rOOm7twpEtM\\\\\\\\\\\\\\\/KyB8LZnMJkG0FhBUAzAJ+EuUIGQdpIaBvBPGXhaUp2JOF65pPJgyBpdznc0ZYEbs0J4ht3wxam+c8y10gfu2N\\\\\\\\\\\\\\\/9wNB7TkZpi02AW7mdTicnShX1M4RjghCI09HElPv+6sZsFYtTIWZpOTbd4KBI1dZNA7R+ZWZ21i2WTTjVFBWx30kGKa1k+Zx8cp5HorUST+8uMh1hlcyucTWThqWNyevWLqmX711dScCnLWU54mrm0oqBXdGy3ZKtpbB24puTchQd2Jl0+RfbUqJOR8TclKOoSBbhMV4ARCtJUZcmh0IxeiUVJ66jzjywivyhK8fCfC9h5Z+mh6TOgorb4xrLR2MaksVzi0nN5I\\\\\\\\\\\\\\\/tn2szoOO+dbMbQvMjOWmvJD7nGNQe4eWdGVdOO1SZODtQTIRjO6XLluXQqZf7NYEP28rtNkHOHULxrDPB3M6OvqLQDKMhhDJ21SC0K1B9BjgBO58JPmTKDR2BuJJ8Uh1Wl4VveWCL+Oppv5L05mr3VI2uzRMxz+5VBuNV1JxZ0mk6P+7bp362YYUfamQVwR\\\\\\\\\\\\\\\/4nhHyK8z3ocJAVn7t5V4Rl3uNWUGH+mPVG6bf3zCfYxGIXeHnKgbLiwTi3C1Anmkj3+7eERrXU3l4F11++mEWd6pw9fiyBYJ4j3hxL80bnlRqzMH5BPdhnZQ+3ZSspLXl5kGptZF9lMRwH9cXJ2GH3lPbz2uhe15Ta9FDD5iSKHulKa\\\\\\\\\\\\\\\/c\\\\\\\\\\\\\\\/NZdakLJ\\\\\\\\\\\\\\\/jWdyaCRpkBSTcPlANJwieSAqcV4NuFkduhb19YqQw5XyhIbr38+IBPRiSxUgSNIXCpdQZevALA3XlbHIIHm4u62fmVspNg7UEXoFtHBk0KU9Kf9Oaal77rkt8FOBJSMf5LyLGPSiLXohwgkmTzK73WRyUxUVJprj8Fij8ZdbDKjv8t4rNl\\\\\\\\\\\\\\\/7WOVSY9imDb2pXP0MKU+iHapwdFVHAWHE3jkOxWwWWl8Y6+44fLXEi4YkpVkdMjIvR00nwwZTGBEfZWREBgyIgrTdgUpb6utGoiFmXcgaoQXqb5THBUxzbg9PSvPrz6fpcIuIri\\\\\\\\\\\\\\\/EPS3TmRxwjL31DVhqQcnoxBNjilHFbwJ5cyUqF4OHD8eDma4eYqGHU7ZyVSIcbGXOV2ae6khkA0aaKOEbYx3VguQZpUp4zZYQCZXtfQHv2GPyWHXIY1Fsr5jC4AYedaXd4\\\\\\\\\\\\\\\/KHrny\\\\\\\\\\\\\\\/WNbsjqpSOaLIUsFGazXasMskdudXQMckhwKJucFrxwVxmUnB38KVtMv\\\\\\\\\\\\\\\/DtrfxXFMUbJk88J6mMDBRO9qRFKHxCPkTHfEk9IV2l2y4HVTdjtGbwMqCKw0BH9sO8FYD+1EivFifbtmKhg6o0JG7r1XkQP9\\\\\\\\\\\\\\\/FIfnXiAGOKHPgJ8jQth65KiayVNE4XG2CWzaeUdkFkkc39BYnCnAr9sDkvWouw2D2syOP0dWyRrdjlRReFxHqyDUy5Du7Kuw3morPJmmW41\\\\\\\\\\\\\\\/QA9+S4mOZvPZLwDiFa7sTIcJA57Exp2zygcz8qUKHGr0l1bke53xwPYtjvvx96t4SPAmTe5lywodG\\\\\\\\\\\\\\\/MmWt31Cxbnww0dY43+dqHGeR2srUFr\\\\\\\\\\\\\\\/Zz4GkFdicfbb1VHNX3uhVMsjKxRXNI18cPRhTCGoB2LHv2cJw9XwtA5mxNstfqLpu4sw+oa5TZLhxFLEMVSw\\\\\\\\\\\\\\\/WDBgfyX5k44MuL+66J23oic0OU+arGUO82BAck+EywMW7dYCL1L3M558MFE4ZYWxD6jn3xGcYjehqlPMn41PS\\\\\\\\\\\\\\\/9goSP1CHIflLcZax636eOIigKtXJgoHwMe5eZf3vMG2gvpATwEvJHejoq\\\\\\\\\\\\\\\/0vRK3GBBQlwBIH8aHLaUJhhqKez+iSm6104ZiNnF1OMFdiPRdydDq+F3tpI1MAp6wwfRZcxNwiv61Q5fUt0LMWEjDyXpM8dsI8NbnojTfSM85bWneipS6r9VCrndyDxMxnCJWbwa31xcP+BicXEcxntaob\\\\\\\\\\\\\\\/+PtIRK+2tQ8LlhqymvVbltDg+IL4k7V9DeCXOPWTboKU3wq7jfWJwyegdYNAa3BZl6uBTRD86Tgw321vJi++El2URUN4pL3N90NfOOHRi+647nb9ueiQ+y3euDMbHYXrnrvEv4g49CxSkQy7DuGlPJX9CCEunBirqWp9auhCDNMsTyTFLAdQMJwLRmUVNxRKAb+iH6PfPHj2Bh39VfxeOSg7yc\\\\\\\\\\\\\\\/AsPJZ6GKrcHT0=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00224TyNXoRjRVzS67EJ6sV60g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00229f9e10b63d78c02317a6b1ab4c30ff0626a7b70812ba413877ca9ebd629dc2cb\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/82.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/82.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0396-9\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0396-9\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0396-9\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}