{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022mi8vYWu45zNYkKvv2KeM\\\\\\\\\\\\\\\/jvX+e74m1pufBuIugRCes+OXMZwDoQYjgru6tUPD6i9zgBR2ImjN+s2poxnV+T1uot08j9udcK69HmarUfefGLJD4kMQ1a1YwIhY1DZQH2YAPqsERG02okoaHwgMecp7Ze5o4z4N6YqH7spL\\\\\\\\\\\\\\\/dsgDBw4BsyWO+\\\\\\\\\\\\\\\/FF8Vw2okURv+X5SZ4AA5ipXFPkFI5Q32UI7bdbrOixxp17RT0CcOmLfej41wiPDDQnstF40ssFMG8vyUiySmwP0RQKT\\\\\\\\\\\\\\\/28Zz4AnhgfGesa2yGfMhONeAZ43p7g\\\\\\\\\\\\\\\/JFoj1\\\\\\\\\\\\\\\/bElKj0IU4C5V7wEUbidCSzX8qfL2Lu2eSb8pu9u6S8htQ33JspYp4OkRD6Rlw1Gbg\\\\\\\\\\\\\\\/jQe68sziqXDczwdQV4s\\\\\\\\\\\\\\\/yWfYuiddfo\\\\\\\\\\\\\\\/klyY3bl7Db4yFQra+lmE\\\\\\\\\\\\\\\/MsK2TtvLGSjfF87H\\\\\\\\\\\\\\\/fEkTt+L\\\\\\\\\\\\\\\/XFWt3ElLP7E7rC+7OE0rEDUra20P6yTI\\\\\\\\\\\\\\\/biHOQzFbWVfQrR5zUIPiVWxDZdNthLeTZtULdEUcX0XBuQsKhXIKnv3cCUamhOKytUD9EAZdP2B68Mx39lyOoYOM25YHEkcwbUSiFQKCkyvlgl9ydfHMrGYmV4b1VXeXkb2NcncM+T3\\\\\\\\\\\\\\\/hMbxeQTOgvC65ZoOnTDaF+mGRaRuCkcvQ578p4O+q0MT\\\\\\\\\\\\\\\/6cFkStXz\\\\\\\\\\\\\\\/0LWt5QGHzZvhkgLEkkcjDQGUqPi6i5QTTF311Zo2uK8w0OG6pFGBGEQ5vWIRZEhfP4HGyQLKXBFwHriwDhx8SXV\\\\\\\\\\\\\\\/kyqXfg4jZR3eYoqgp8bQnQNVDgsVCf1c3XZNWcd9O7610+UKijsvp98Q05ZZiXc5\\\\\\\\\\\\\\\/G8AbvvwDKeand5B7cx0bSrvwoLls31z3h8Uo88oIeT7AAYU\\\\\\\\\\\\\\\/DNOTiI+j9TVlRWOofB1ajVeQa3kX9noiWD2FeqWkA3rqjPJ+xYncuFdYSXIkyJaqdgPXRyeWhMFBorw9rCH0Sdnr2SLdeGXA1VyJp4vo5PD5PhdO7JPw0TctCt2VfqFA8dItvV9iRHCcEiOGtF5DKJfdPudGYQW3Yko8hBt+anvoREdzaHl2q7WRJTsvX2tDMwmHmCTP9SNUBV9NTH7DTV4ZQQNq5x6SCdAHp4Qp9Gr69RIU2sNYZ4lOcg11TJW4gyHWdWMtNQHx1gMHUAWBH5BWtq7suNkJlj1S6b2RT5Lqp+xWEnKhpjQQ19ZsuYDKn2flSugKMgFti07iumJQ6rHlq+AGPi+y72JUEQIzHJxlA6OEjGaaLNR2NV3KRxXHxThhjCjoaDwcbyvva7rfrNhYqPJj68w1\\\\\\\\\\\\\\\/9eOUowbLc2t46\\\\\\\\\\\\\\\/glG45RFT8qq1OCk5nAxR0QTreXJtcSuFwHpIiVtUEkfxXmNy7gYqWZvhneXgs4QF2gGwsG10Ij864cnNdYQztphkTN5kZPau9i98eRzdgWa8SZ4qH+MnNtXpwoPvGNXTO5uwHUOJmJ3bxPfxUqrAA57m5M8LxVqtlD4J3Zif04OyGhOym5NGDZXn0MTRXQAGKSWiWZRdgxKV6QlbbVOFul8SGmXwHZwl8IIca4qHGBQ1dTpIT3ROOlnGZhQg5DU2vsym\\\\\\\\\\\\\\\/bbgiH2U\\\\\\\\\\\\\\\/gYxW0yVHNPuDe+Wgld3OzIK7fj\\\\\\\\\\\\\\\/e9cFITm+fipnZxSMDdeDy9Cmf9T1clUSN1eXeNU2ZKmC43fPMVGlx8BCvAb7dBDK+MRHyY6z2FlmX7UACmGnhKDQUsPgUjk8QcnCBaH7kqg0Pfuj0EcJuBu7qnSZTKXi7FEDMgN\\\\\\\\\\\\\\\/DQ6r\\\\\\\\\\\\\\\/zjT2M\\\\\\\\\\\\\\\/ghhGLBE1eVD7u3Q0riFY3AzMLtwY\\\\\\\\\\\\\\\/Ysyv+TVeN9x9s7rzpxv6TnkGIl+hLeHTxEIrHMKMO8M54mJXNFSMFN9aFsHxv9VwD1usNpoadNz2n7FS+TI0ETS6ZMV0c\\\\\\\\\\\\\\\/JHsxvwbXsZkbKe95ezxmbhgaNUpq5rLIncdaEQCe7MvU9e9gd6D4PhuCXDp\\\\\\\\\\\\\\\/TtE6pceJewwFX\\\\\\\\\\\\\\\/OS4I2CoWiTQPURO0nw11OwKpdb25ydFzeoGpoWLdMzCHlWx6W7c+ObiS7Xm7jNkluk\\\\\\\\\\\\\\\/oTeuNfL+OibXnly2Q\\\\\\\\\\\\\\\/PcnDxIwv0SvS35RDlwSGdXp7Y\\\\\\\\\\\\\\\/rWjbMtpTyAoBSWbqIwh0knKarVESHmUhbecMqAJgaJ6L1OWg9aJnlueYdLQXPNDDu682m4e8g2iPBESAVQ1EhxKSx6C\\\\\\\\\\\\\\\/JSUH+g9q9bdFtwXP\\\\\\\\\\\\\\\/Ne1b7ryhB73N3macq1qcwmV\\\\\\\\\\\\\\\/sdyikPP1fX8ICkUUWoZMzneGZB8C1xq92piJ2qAvsUeciV53B\\\\\\\\\\\\\\\/dmFmrLgGNRhs7VeiAkJ3E7zHpuVf85TAxtfbs9x5L6OXT6g9uVzNOtC7bR7umAnCKuRV5kcd06AYv2HqgswqH5kz9jgVjCsa+15QWLU7jCIidNh29u+R0hs+JnpDYHgT71nMiNUUVPFAEfVJTc+TV4VbSRAoEGzS9RGWE9yuew2e8OspZXDMKmLAJLHBRbL15JLtpDg89fl\\\\\\\\\\\\\\\/Zg26o9rBIrYj8IbkAhkqU7BonnaFyzCDJIU6uBWbP8y+Uv7u\\\\\\\\\\\\\\\/tq6nnqWO1jwmBUYtQBfcSknKuT3gbUqAreR3y2gv3lERjnAhLoqgjm+JBZaAhtruaT9tSjUjgTxNWaIwGJG6UsC+i3jv0IexRc8Idir+0=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022GmOVju22HHNeYpANFi\\\\\\\\\\\\\\\/SIA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022bc735e439c77698ec65bf4bbb1234c58e9219f0af1988b0d888cc52389ea264e\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/137.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/137.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0460-5\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0460-5\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0460-5\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}