{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022M10eaqcn+LWfupjwHCoErqG0zzLgxvdOr82wU6svpMZbvJ2ScaSjMtCtn3BUjHkGsWtK16di2DaTPfhDxqjZ+3pYOVuTQn3TCDAucvFwVseSPrEVOz8K0\\\\\\\\\\\\\\\/oeVOFVhdl4wQrOrdlXEgofNYKQ0rVS0TpSyANub1DNvdea+AKzgE5\\\\\\\\\\\\\\\/lLvjiWAKapadcCJ1FWq9h0n5J\\\\\\\\\\\\\\\/TLEKn7YYXkfA\\\\\\\\\\\\\\\/ZyISHgjbVl\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/OlnS03ceU1ZsSRzzSYmBldyG2Sfxh4ysdkcOSOE3ZQBBfodhV23H0AuyFsnk82UJiS7Bt1BFblxg\\\\\\\\\\\\\\\/ve0Z9QJavN6icNp0xwm1FpFE2Ez7sQj9YDBjmKddQ4q7rvE18EEOQbnP76\\\\\\\\\\\\\\\/pik48duQ1yDEJKolKi\\\\\\\\\\\\\\\/mOwyzQ4i4nnJ3sxxA7FpUexO8RQQk+MkcdBCzqefY7FuPJiVQ9bAZPtkbYtcr+cBnNbHALgJEJlhRP7x1UOGdAEYA\\\\\\\\\\\\\\\/RjbSfFRPjpBw77eYi0Xv6cpL4ZFiFOOA5XtCmUeRYKf0gd14mOhMcNFRyOqfvjKBmUKWI0thlF7Mk9wgUlNgLStRSZwz8QByCvNR6aLN4cmhETUlAfYmbulbpaUc8JJFaptwqYS7sIL0nx9dZGklBkMmo+ryugzzIL5ERFqWmNkHSELggrgkemWSiG8zkMbr48LyIsvpJOToHX2weCSWKCNjhDT9GRMTFIjUnTHsKA4gpWDmK1qNsdr69RiOJL9rvoL4XfO4CIUAK69SYl8p5\\\\\\\\\\\\\\\/d1qF\\\\\\\\\\\\\\\/6RrD3tMMkIaQcJjCxhNgiqsYdf80ECguszgNfywqamUYDubqIlz12Ceyjklr2+UXhTnJoG9qhWBfmvLgzaPvb1oCQsBODXF3Ce0dw9n+YixNED5UyVPwied6TahmMgTEqOY7GWtx\\\\\\\\\\\\\\\/3l4FJhrER8IBZESmsDTc7Gjk7fzZCdH\\\\\\\\\\\\\\\/yGE3pL1WIRab3k4rvV9nB2w8rM36oglDi8YpPF2\\\\\\\\\\\\\\\/lC0Odagkg8BxzufHTlvMwhqCMSxRX6d0T+yHR3Kcq5arvFMwt\\\\\\\\\\\\\\\/yByPziHab6MkH+6exd3hqdf6OXinUO6qra\\\\\\\\\\\\\\\/ZfE9CRcfyFNGokQkXsxSDDEVJO+oPZZPLdWIndHVsg8e8kMRZkVwb82TbTLMwu+j2Cu2QJrQvhjQlmZn2aoejjnJsQfnE2ws2JGvHQlKhjkVeSEudvTCii8+u26Jp1YkGxz7h\\\\\\\\\\\\\\\/XLcqR79EFjuprvvB9DUb3mEtkN0pdVUm7dMMzVG5ZWsYS\\\\\\\\\\\\\\\/LKNUc\\\\\\\\\\\\\\\/7X5LCmqqo\\\\\\\\\\\\\\\/CWIHNbaTpKFfwdmjcckigApR5cVTz9y3q\\\\\\\\\\\\\\\/M1k9ACDXVzGINXjgZGR7Z7hQEnaelp9Lvgz5iLQe3x5irf51lGfcaq2SewdeVE+LRg+B3MMMsV+sGByt4o9vUHuWUuutxIpCKEZDyDA33ae7bE1nQHK\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/J4H6wFYbsb1u9CsIdd0Gicbuc1weW2y8B\\\\\\\\\\\\\\\/lqAikv9mnWj4CvgNr1M0dTGi\\\\\\\\\\\\\\\/y51DYRwhZ23nL65f9WFRVyr05hzIVtOVDNjD0bWQI4lybRkQcDeBUKWYZsAuNM8gVVcc4VkqDm6ZOws2AwyF+mTR73vOY3gfbdCmnrSXE5+AKzSovtQGiPWaoYyNyUd1jX8jTO2NIkrzv9M\\\\\\\\\\\\\\\/98F+NI+GmpXdCDC0GIurGkogjicMP6Ts\\\\\\\\\\\\\\\/x0yLZwGeeKnqe1XqhXLazaiEbGkMfpF6U7O6cKBv0sFRhQCm6mRza8Akh7iujIiBC7fWpN\\\\\\\\\\\\\\\/EgIQnn0mfm4OhFCKZTs\\\\\\\\\\\\\\\/ZZgrf17S8YI3gZHd\\\\\\\\\\\\\\\/eu4TxWHQip+OuLNqTWJi7wSbjabtg9GAPdc73CU\\\\\\\\\\\\\\\/OeUCBVau69YZzdYrP53cYLs9HetwBaoSWW4tn+e10XA7mHSQEVXSLtoKBZUptMBO8kQvtmRy16jroCRrmpwc92+xa\\\\\\\\\\\\\\\/A0eQyVL9xwLDkR5RC8AIjJRXkfFLsGfODCIrUVJRjv9fpLbdn+vU6DdryiVDW0zKm6v0Ba5eJdTZOOTcmVVodiQqMlTaxYCXoFfedE4nNl9WrEO+wURRi\\\\\\\\\\\\\\\/vSdSdZODl4vFTMdrub8f5sBcY3rPFA4rEA1bXopBkkwUz8zroQgUncXraFP2GDyXgREoD6dhaNuHyuOnn3eovTDb\\\\\\\\\\\\\\\/gkM7p5STngFkR12Z3ePMxzY7Rms5sfQ6SgN7AWGSrz0BheZ8j3z8FpFJTvWyF4MslTEBQ\\\\\\\\\\\\\\\/GwGdVlEJyOpOnMYNQmdHvCxCTISs5IpEhKar0xTC9jEFhBioQbkmdpr4060OTjbJtsLjkiRVosuQAHF1G5IyqFEZLMLMCEsPB5ktF\\\\\\\\\\\\\\\/EIk9lt5lcNW3TfeUs3uVYfTd6kae3+jYqOZkicvADK7\\\\\\\\\\\\\\\/l12lJA9WuxDctXexhinwqWEwUP6Vv8y1kbUuLoIJW3P3nX5rLfa0kSuVTiZruDHO6oed3Lo1jI7RJfqedA4e7Bt1cQD75cwz\\\\\\\\\\\\\\\/shqSh3b5pNxRKhKV3uPMYKADOMMWqyuqbCA+cNMyuc\\\\\\\\\\\\\\\/Qu68cTcHWDMlH29z4z3gtLGiFIMpHmT+Sl2P9szTT\\\\\\\\\\\\\\\/USJM4BuYsNN9mlHXv8GvQnoQDxbuhJNGZoLzSFcugHn0XenrODUmj\\\\\\\\\\\\\\\/OStNPsVDwf8O7FDeC1DKNL9v2d0o0M8YR9iLKqXRZNnK1f7rNcXru0EwjVW5BgaoK15GPYUqEP7pAM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022dk0twMIPR8Pv4Izuc6AXEQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00229aa491845b7718f1c74469306d0df99c7cd7485f97470d6024f628fd4165a6f6\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/45.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/45.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0354-6\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0354-6\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0354-6\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}