{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Th2ScpvyEVHwGm0ZGEfEJ3lyZvTbrFjQVZjHpLSwpuGFD3iG6sO3fUPI9cZaSepGEos5NHo+U6q2qM8rqBCrb03ID3l3uAPXAN6Dgy3FsjTm9tMwREPgEQNSd9\\\\\\\\\\\\\\\/IfhtSzGajs2LII0mzNFwBPJlFw9APcsxhJ\\\\\\\\\\\\\\\/h2+hEoRN3cMjswuRVHv6B0U2oHVPExAtv56XfSx6hAZ6KM27M6La2qIfiMqKWZwHXCiWpCmIril8SBg6uR728\\\\\\\\\\\\\\\/yDayMNy1BfYkzKJtBqCu7LEhZ+UCnXBfsCfMwzyPdnBZxvveKVyCOhbHvRoB2KW7oTq08nWtTSR3wEyRcqhi6\\\\\\\\\\\\\\\/Lp4r24J4LBhq4x8iJq0L4mCAnJbhjdXPF\\\\\\\\\\\\\\\/9BOpeNuEHffwuCHWv+jfYNAgCNJTfuML04W6OHMtBe93YPCSSnZWXNqfbkr91nrxahmWLlMfrEuPnTKQvARHMk4BlcT6t0q5DeDrtbNzbu3ef7xqIQt+\\\\\\\\\\\\\\\/T1gqFhyxJa5AX3fRebexClCQIU1QDjG5FOz8GhzuzUJfqz2\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/XBy0i0guj1YOCOJpfUJmcBh+ibj9D8jJRWkT+NnneJwxMi+PzMixPVFDo5Ik3\\\\\\\\\\\\\\\/A6wgC7\\\\\\\\\\\\\\\/CwKUlJU85GvaI1OhiEtf5in7q5i2HjywXpW2mdE33I8QqMrshFUfoXgzkodWBHBty5qjzF0XSv2IABWtNv4Lp9rU0GmG7cb+98kn64EFWusYKn+aoWbPyiuqKEaVHz+XnNRJTBBZM9MEOHEty4DCEZJ3v1eGEGN5xiwFaNomrhf1D5adm7R1fE+CUkMdclGDeW5DKT2CIGHLNvRmqHqN77RJzst4g8164e\\\\\\\\\\\\\\\/8rCgL\\\\\\\\\\\\\\\/xkWJqq39Ux7\\\\\\\\\\\\\\\/YBxyl9qKBS5sdckGvFs1R+bN14J6KHkBZUM8RG8WuZ2h0hsm0TSwPCDU7TSS3Po\\\\\\\\\\\\\\\/Yuk8QYexEX3xnYSVpPSa1LortDUV\\\\\\\\\\\\\\\/VCtuLoNDPWlt5Se\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/UniJ7hft8j20ixg\\\\\\\\\\\\\\\/AJ7r53ZyWvGfBdlzUH+CTY60AODRcRMzgcXVTQbFBcQewQ9dMv\\\\\\\\\\\\\\\/nFkX7SmMs70su2epyN9Q3x+hMsTv0OPdL\\\\\\\\\\\\\\\/Rtw6HiLr+x3XJrluIJDSbNCyLuUsv6fS8dW\\\\\\\\\\\\\\\/czxlYrFU45XHiAJ4lgtoTORCNp9Cf6fKCxeeV1Bl+KKgQ6gweZihXZqK8bG1fp4J3VG8Kf5rP4tDRVIQVwAClExx\\\\\\\\\\\\\\\/mYyJID\\\\\\\\\\\\\\\/Gui1\\\\\\\\\\\\\\\/hQxPgCGDSsAkQTKDvFLEoCS2T07nfRfLVANnDmV0Vj3xfjWExsbKDs2ctPxJSqG4yAX\\\\\\\\\\\\\\\/3JCqA3rUD3JoZ98cI6obFdYr7zlvWXw0Ecy1hMejBKpnlI2NgYND\\\\\\\\\\\\\\\/5ZtFlrMyMt\\\\\\\\\\\\\\\/K\\\\\\\\\\\\\\\/9EfO9\\\\\\\\\\\\\\\/eODGchzL5ig\\\\\\\\\\\\\\\/HNhJNruDaNLQcSms2phOp9efRe2JW0gUltp0weHS6kqCXjUz8LD0PYFD8nXy51OZZqGBrGsAVLogUNaTVA1GhugzDUzaBfaO55GQ67aldsBJM1NvC2aT7tzLjtxDfJYubNSH4gfmtnM9yqkXAsd9VOzdWfTLn9Ocp5ZtLrZaC3nKolJxOuEwHDG+k+kyFLjecCMz70L6PDhMv4GGf5LXuIlx+NVj1V6XldXTWaDfq\\\\\\\\\\\\\\\/OmodVO1nOq4878bq7QZVDiFDIvssbRZCfsyiNbMaZHU0Bs33SufcEtnbr2ubLz4EGfsXAgRtmTXXpSQa46aFu6xYLBwWt98wr\\\\\\\\\\\\\\\/EamDkxIn38XGalG2mWj9ASguX2Qz7YE1\\\\\\\\\\\\\\\/UA4K7VD4yRVjEqaMKb1Rl6IRCxIpNWvxhehIMZybKaec3JEZ8dJr3pdxKPayIQiCh44zT12kWXhncQyef5QiXPz5I+Uo\\\\\\\\\\\\\\\/QZrw1o\\\\\\\\\\\\\\\/eAwtF48fUY09G6VD8tbuHy5GBeuHkNSnyAmz+QdYdcBCfhhv6fqv8ooDk272cqXV\\\\\\\\\\\\\\\/FIseObsuseLRHE2JWvi0Lc33P2XYpBLhDHZt5hk9rwY3\\\\\\\\\\\\\\\/1T3KU086mq8oq9PZgYevvpjmVKJYZCSLIZgAbNnn4H7jOILec2KdDqleGWqkauylukxoUOcJLaOdtrpjHB2eZgfsDOCSGNfDoqPNCy5iyKX4U7cxGtTOFWs2oly87JFGTze53Oh\\\\\\\\\\\\\\\/Jc8FxKSjoxoX5X914HLbqzL5aBzWd4P2FEctP78DBrIVqAg1R8elUlkcnUu5x4lA+TCZbgjdkxDjkO40n2eB2l5BuT5pR\\\\\\\\\\\\\\\/bF1LVXLfBUzVlaLidMOgfbKc1O+J5JvBW+s17DdY4shVLI5ICc3J+owvVLgxNkN0I9V02Q7geVVmcVwXmATNxQWSgfuoY6I\\\\\\\\\\\\\\\/OqKddJ6Jitu1lolzlmOTSx1ocBVOUPTky\\\\\\\\\\\\\\\/4YXbbdCAScYqaAE5EUW29p\\\\\\\\\\\\\\\/sBYfos7sNFyr4NbM7nujEuKxLeyUTtGTSdyO4imX1OpieCnOQMSOJW8zkMQj82sdS6IPNJjEy844xn5va8DqkSXdbs5rlxkJBSTYobPcV3+99SmaRhQ97e9+Q7KchCRqqrl3RdruWT0Eymdjg7jGQ1favuifuGdoRYWXr3+O+bC2Zz025gjf5kkdXavJqgJx0YlTCryswqkQ90iMVqSHT7\\\\\\\\\\\\\\\/CXwANgR2jLOd6OzYEakkLh5\\\\\\\\\\\\\\\/FvtXhY6X2v34dLCfvOjYFbrbOJm1a2wISfXImPQXJjyby18jHTuuqOTBMtZ8qU=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022OzDwDywuk4PXsZFvU2KrRQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022739a8c466d5ceb6ebd3969b733c321d68c82968e3c0b392cf2f3f3ed811ddec9\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/45.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/45.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0354-6\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0354-6\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0354-6\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}