{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022UyonUjYM\\\\\\\\\\\\\\\/oibyE4tCTe+l740hB90Cwj8WdKi2wQpH2MDYVDpZPjLfrHKXgiUPyxazBxlPJH8NJxkyeIgPClDB3ThdBL05+T2Nsgp\\\\\\\\\\\\\\\/pSpAnIsUHG9bV3zee2yWVujuo5qI51EN0Vu2BKKGJwt+nUYjnypcK8RcOMk\\\\\\\\\\\\\\\/2jGVxVP6XGqe0ZMw8x9T21oFd1cD\\\\\\\\\\\\\\\/SI2sUooGDeiIbXc\\\\\\\\\\\\\\\/5H7Ito5FTY5EpjMtGNQBV51cFGxklAq2LPBzrcRsy5FGYs1RtCnQjBSZk1EUuiohcb\\\\\\\\\\\\\\\/Yq96JTbC+eIYlfT4H3I+Tl+NXXPtvku04OgRb52gMdypz9ANbM5KXdFdCktrAmxCnOxoHDAijgNTRCKcPOIDs\\\\\\\\\\\\\\\/Bi6FJQQV7B7hF5J7cGMccQP8lNEZ47tGDRYPB73HpD\\\\\\\\\\\\\\\/zcTVvYl3OFhuUjg\\\\\\\\\\\\\\\/5tt8U3YcsVVU9IYCxEJSnO4BnxPYnAG63jovr0JJn0D6CBnveW5W12Y80LY9zOCDqviKYrYWEBYNH\\\\\\\\\\\\\\\/qfTBaoDDJxkPL9wr7XNucGEBEF\\\\\\\\\\\\\\\/dNOJeGTWpzTOO9aBvBpQwnpmruFZDVVkFnKw5zvoGPlV7X56X7mm3FowYtX\\\\\\\\\\\\\\\/eBsQ7cK0lYI9I1RvTquBUKdoh2R9eeyodl7qrXJ\\\\\\\\\\\\\\\/Ey37CGe0ztve9uuF6EZm7+UrwRKVzGRgpE\\\\\\\\\\\\\\\/AcSXit+pDaEHPN8K0xo9+5XUZRV2qCrB6AYod1LIlltBix6bHYZwETzaI4X\\\\\\\\\\\\\\\/erQabmu\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/YOlq0hoyyV4+ipo+TwEilabFdBGst2NmIsJNs6Yi2NkJDl9o1zsr+FjnOzVPb9m0i6Waqh3R952nZzhbeBhEAr5dVDq5ps6fh36fOL993bEENC0jJKvQfRmHZcxc0RorR\\\\\\\\\\\\\\\/MUU5YpH3fpDdF1YSwyvv\\\\\\\\\\\\\\\/+0BP0fMiwr6kkT9kh\\\\\\\\\\\\\\\/rLyLTAwC\\\\\\\\\\\\\\\/davHH2WyUqaAMoQU9YhpcvRN\\\\\\\\\\\\\\\/JdBsqzwgH2UygrYjdOUYW705TFj0P6hMkuxWLf7jJy6hl6MGMGGTd55l\\\\\\\\\\\\\\\/V7Hmmp6pnlrwuX\\\\\\\\\\\\\\\/MFJZw\\\\\\\\\\\\\\\/YwpWk9Jh+x+vbU91E0bMn0WD5GXEZJn2M70g\\\\\\\\\\\\\\\/vwimkF7XKrrG8RsWuu0ZUFLaCFwyz8Nb0aQiz1da5WRAIV3NAU6JOZAa9F64YHSsd2WXlBflgFx4JdcbviwCZhkN8YQVuhir6XTFWBl5Hqbre4xn5wd+5r0dsk29JmP3LvoCETCIQ2HlXk2JJjR7xoyqLmHW4WrL\\\\\\\\\\\\\\\/k3WyQL6E3YbJVysxyCze18N\\\\\\\\\\\\\\\/xrg\\\\\\\\\\\\\\\/QMJEdMk+Z7F+8VOuMGCl471heL9N3f4dhdxxqyZ6mnRI7h\\\\\\\\\\\\\\\/g4kgx5oPvrnBW2aUvzAs05eMAuvDKG1calaMpOwj9bRF4VILFdPopgE+xtqAH79asqpQ4wu43ZNVTjhKwxPvmOwBVUVfBrAsoCq8IwtFRBsX8uoAQdGCifsvguHxSAzQG2\\\\\\\\\\\\\\\/9lYlRlgZX7bBMwDuuldhno7nTGqoL\\\\\\\\\\\\\\\/vSCUuwiT0MsyFotf3EoOlk2tnhfM4K1yheQkAPHO5PfTjPchNEgiFMCEhSkoL0\\\\\\\\\\\\\\\/5bTksZhPZKTdFD+aOFRn678F\\\\\\\\\\\\\\\/GM40PglTbvY9ZFb9h4tQnm\\\\\\\\\\\\\\\/7RfJNegUULsTpwuPxb09QRPq58sr\\\\\\\\\\\\\\\/0OP5yKHV66dBhkf12yNt51J0yq3sTgBT4LobYV6lAYICS2EhMfhkE5Qs2ziCmONUZaQ4s6\\\\\\\\\\\\\\\/CJT8GN77wbmn4Au8drEvEUk5AYfvIKd1ehrQ+hOseDv8zBymUkYm56yIXRiWfUgl0sz4Uquqpps1I\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/ZRKSNd\\\\\\\\\\\\\\\/BbkjBl3ricJgn4cHl9s6hYUS1wiTExaWC7TKn9h2x4blZjiTQRg4eu3bur3QroDOeE9uO8Q\\\\\\\\\\\\\\\/w4WmgZjbIIXgObJxqq6l6vARVkTDqYl5\\\\\\\\\\\\\\\/MhnR96V0RoTBZPFzCMbKUPTQJ9HxobXKs4V8uRcCwD7hYS8\\\\\\\\\\\\\\\/QJ9mXQbZqLzerQ7sNA49XweLopLzqH1tbB0H6q3sBQO\\\\\\\\\\\\\\\/9OY2wo4F3ualSgVerMcmlP5Amef+esHokr+\\\\\\\\\\\\\\\/bXV+5MaNFshiXFhY4rzrWAKaMlVx5DZlyDidYd3tMKc0\\\\\\\\\\\\\\\/8YCrURgnmj9tLtt2ig4jcfcq6y8HytA4LtJWtciG8TbRrqDGRZQlgC4dCSCBrVJPJAo27N7fBXYZtTqIipR3GpXieZKlvYT1fXxU8g3U7noyHRREs+CiUaLUpHLFuT6Kprb3NdYMJZZg6WDYbZdTUq40p4OCfO\\\\\\\\\\\\\\\/JC0SlOSgy+Syq\\\\\\\\\\\\\\\/5XUXN\\\\\\\\\\\\\\\/qrfiAC3kObkg\\\\\\\\\\\\\\\/0ij7I6EgigYPfLLut6C5ZzfoIMpbmCNpCJrByUKn7KmVj7k8Sov1NrbfmTgnfL8QZ6BT47RDZF1iRcSxlnN5\\\\\\\\\\\\\\\/cNJigigOm+yb1XHXdSrrVv7lGkTJ8g06P+4BfcAjSt0zWdrIDlrmGPakdBB8dp1VBBOND7piHEbCFCrbsYEwaEa1SeGjT28LIiTkELDekBFWXLynCV3DLCYVT+hHr+yi7SFQldYyYBvRLZ0tpW+f9Ir45l0ll8MloGgDh2ev+enpIi3XJJa5MOX1zXGkjjluzpj7vCR+o0JBkoHeW9UDgvN1P20nx1w9OBO\\\\\\\\\\\\\\\/WoUwJyvR84wowj8sVUcBDEWUrMGMTw1dswAJBZL8P0rogMqV+fmDviUrsWg9CiX014ttlXIA69zjzOejo=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00227x\\\\\\\\\\\\\\\/la\\\\\\\\\\\\\\\/yx1rxw9GjsSSAhkw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022ec8b75913b4852805c2f50a59d4f5939359382da12c69e0967934404e770b0aa\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/127.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/127.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0448-1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0448-1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0448-1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}