{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022QcbeKIdDhmeLEyB4rpn2iXXTyJBxui58Qj20l9MP+YVwMP7h5S2ZH+FbxG6QmUfxx4UphrzjETnB4Xyeqy9hAWV1Y25Rz47t+YAlmW7W4wmXm92Ex+zOKOBTw9dmMO3h0+LHhCKmtFykBBhja4S+U9Tt9Qr9WWHaqZQYPT1OcXuMBweNmVcxOeZMbj6S4TljpGQt9u0sT6Cv2qlcAn7L1CulGygS8WEcjY7D1d4Bt5LEYgQV9aTg3u7I5AFTvd4w9cT0OB9jyMONmOTPcPMxrBrwL48Nrk4x7KJP4dh4P2bhclSi4CgIIedU+oxe7oVGI3w0jSQopWQ9awucY+JzUk+gosFLprxcHNz4OfZVfFzCiXFa6UZStTk93P54EfxyFYbP6OFh0GQc0pHtjxPF9Hsz0vT4hIhAPQVO6HT76TGNVEkxEsg\\\\\\\\\\\\\\\/JngGDmcSkFRr8A4hTTva5cmfETNnLTuQyuCEr3g8ehuBQ\\\\\\\\\\\\\\\/Z1N+pd5otLNeRcP3DabgHjSGja52+zFevpctYzHBGSdMG1Vf74YdxL\\\\\\\\\\\\\\\/HStszp2B61hurSQ4jDNW58WfU2gwntUhbS5vDt45Bg5lGH64XVrVqc4dYvzi5khVNAHmoFm+j40YI+JIB1FTPTLw+dm4MWBYQBlZiHNSBbx4jyR4YuU2iM90ikH3y+IrcNt0mkDg67JKKsle2RSwgSToGnR+tpIZbjWnWpnwrP3EWgPGybStjvklzU9lYlq8EJXmgho+iTe\\\\\\\\\\\\\\\/I+d+9Zmj7MuPH\\\\\\\\\\\\\\\/q0Wta9tp6zankWguIzaOk\\\\\\\\\\\\\\\/PLR4m36JBiNv6L\\\\\\\\\\\\\\\/zngeG3OWIz7YXiGnqH+d8cD2IULPuDmdjgFZcCN9StXqsBf21Mzd8RC5xNI6X6iKa7siV08l8F8blbQjKSo7cvvCLYzWSKvjtdEyHet9RtzCIMh3BF+NvojpnbWApv2dcn6W+3IJL6LfCMoJaUhQOTt427dCOKGZSZUZsUBEd9QK+8ga4rk80Uaundd3dUzQCu6Y3+wuPs7+z02J9BIp4XUjr9Q\\\\\\\\\\\\\\\/bY2ybKxu2CndUNp\\\\\\\\\\\\\\\/HVDRxvOEMUQxOcy42E58OGF2sJomrmKJ69Gq0yGLu2AnuPU45qKiOTEX3i1H9TRpM7uNJLu638EmjvMTydVHUJlJGV9tgsMNQv5nCUs++c5p4SEWG5qRb\\\\\\\\\\\\\\\/7jhRNdJkxVRyFSdosaGz1msfd5N2m7HEQF3bPwiBjoD28FCy3hPxzo9wmMUFaJ4b2pBbl9Lr1IWZ+DObIv0PUCGDXWJoVEMIBhT9G3jdP04ziv1Rkte\\\\\\\\\\\\\\\/Sa5RMbuqoBIV2WThnRlO8lDNEw4dbK9D4Q5x9vjRwmJKOC14serxq3D0jAV7SB1NtJTEIfFPY9BQJl9P5Rgsf+\\\\\\\\\\\\\\\/qzAsEWNOT0VoBBbiF5rfZ+xL7Fp+evcGeMpJo3yoaNsda0fBIwcblM7UK+8bnJkVfjyiFqNvHw05K+02UsPDS2XiMx\\\\\\\\\\\\\\\/NY2zSVN57IrtRvIENZVEoYe8ZjamdWmQ59Qr\\\\\\\\\\\\\\\/2TfIlbqBfRMXWUMjht+goEviVcq33mJv9YbeTpBIUh13JpTePuag+i4g6feV73Y0iwa\\\\\\\\\\\\\\\/P7jMSr3yaJBonBBGCTX30yR1AZ9WsTCPysVll1Txs3tspEzHpfhWezkI104tq6vCX2np2q0jZWeTvMWTH3P6\\\\\\\\\\\\\\\/H2WaX3ni7TVu\\\\\\\\\\\\\\\/yQ66WQ8jp5Ox9vMYE3WxXpOLa1tunjaR2PrFu7CqhRMxQBC5z6sFqp7FTansw6v5fNEPa4khTqmLHXwXaBhJu2V6rtBybA\\\\\\\\\\\\\\\/t2DR90Obiq+9AG1ZUZGJbYlnGR7d5rm5x2Hqr+HuEek8TYht1BFDmeXLC1kgqnfm8aR1M8aUWaw6QoolwQp0y2gC91hutN7tGxnNWMlijcLVgCoEYfd93Et0gwJoP9PsPg9088jhQXx8YNNDue2Q5Wl8f+6BsbDcrLzqsYfnza9fKXrDSvRHvgjR1kSicFjvP27p9n4abg6NiRR\\\\\\\\\\\\\\\/+8+1kSJbGEVQm2vQwuq1zEsD6\\\\\\\\\\\\\\\/UA+RxXFOwmkDl+mMpnbOpvtHnbir57ZMadW96dZLkqizXKI49LOmqwzvyJyko0vQhQA2IHRRphJ8V6qCDEhOonvlgsCbUD86ZPfWr0fQcfYsjxQDU7SlFEdRKk5fZjRtriUc8zkvedrB6gVpTTh90F3XaXMef7NtQLdcpmWCoYbgLV\\\\\\\\\\\\\\\/HgAaANQ+hPxM7KVArCT4cxWYR+Cu+cSbRb2sQIo\\\\\\\\\\\\\\\/6vNtjMn2g6c3Bapm3fOC+Uep\\\\\\\\\\\\\\\/fmZjRXClqPeWv8ceI4pmPtiQl8TTaPo4ZU6pNVh7Jcsns6pK3O7iA5\\\\\\\\\\\\\\\/m3KqbeW6iHA1KV4MVG\\\\\\\\\\\\\\\/Ri49pQYDS2eFKA+fAcz2m4xJImsa0x4V5LvwUL9X4StL8\\\\\\\\\\\\\\\/DkTiIKa+Del\\\\\\\\\\\\\\\/fgdPROoCiNDkgkp3EPQp1Gr0Q7uwdHHq9K0nnlHQ+YG1+G+9K0z1AB5Ef\\\\\\\\\\\\\\\/pFdAXY5iRVzZxxrVcj9Ubwwkk888isryov7K051+W6Ah87NRAUiHP6Vz+CkYJUI0l+Fq8UcOfZFNxyrUM9iO11FOpdCBR7GtI81Rm+zz53EdrhXZlVQuJ78nZKsJjwrsqgu6qivlITNuHGyk3U0Lfuzs+jhTzmiEZTpdzut60FMg6lRSKRSmnJqJ60KcV6kSb1+aydC4Q=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022knsdRCA2MAMoZgjkzANMrg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002242dd1439a51b615247506d26a99c0469e8404aef370268b602ac439e626d8d24\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/141.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/141.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0463-2\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0463-2\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0463-2\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}