{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Q27Yk3Jj\\\\\\\\\\\\\\\/Qsvs2JnfjGlq\\\\\\\\\\\\\\\/Tr9Xr00LgSgmrte5ivxcAbgfJnXeIbSUr8BjFxFB50TD8sYOwreVVgMmiX5sxeaSD9ax8n0ydDBczrbNe0m7aukxGsETBA1SVf1DJk8uaMEOJ35WN6FbtJL+obOyBHwO1dZY4x0QHk76wsdCq8JJX5yExof8\\\\\\\\\\\\\\\/OQiO2ew2ydQpdo9DIrafxEUUpP+vxi1EH7fwfcnIMz3ZC16arAugPsEI8CUYpJFQDROAAxuo+Q9GIq19o4SZ1gi40zS48\\\\\\\\\\\\\\\/uamX4NW3w4qjSIB3aWnosU\\\\\\\\\\\\\\\/3Ex\\\\\\\\\\\\\\\/BUoQUv8T1wUaRlewURA\\\\\\\\\\\\\\\/jU+fIc52sXxyrhFtauBykM9pV9IFq03gASXJ33MIoGzR4hBB3DwT9aHjZ4w\\\\\\\\\\\\\\\/+9irhmVIEE2pj\\\\\\\\\\\\\\\/h2pqn4NBAyGU2PnLy5qoTp+XQVhN5cb3vqDaXpOy0o1OdVgZjcBSvcCgoGn0UnVLW1jGg+uwDoEGVA+E++1tCE0fabO+4DaVFqNvNh8Cz+v4jp\\\\\\\\\\\\\\\/tuTiD8MmICAySab6+DvV3lBEf3Kx7bG6qfPBN\\\\\\\\\\\\\\\/wtY1kXxB8qEZ3TQ3wZRBjTYhb4KT57XYgZJ\\\\\\\\\\\\\\\/4LlUaxmXFDgCUMMRyXPGDCAgJ+2H4vNMLvvJhEl9FbcxoWkmj0VoYqbwOpSEgXc+3WaP0q8Xkyo00E0cL5FrZgA6a21n+mrYzORmTlRlU04WJyko\\\\\\\\\\\\\\\/UV3ZPJD1GZ4B+Vmsep+fCazw+x3z0vvNbq7AXpRHZ0j2s5GzruByc+YLOBDHnfYKsQFSve1Pl3j6gV7pnyQO\\\\\\\\\\\\\\\/VikjmAJJsrSzu+HkEAknpVCBdEiID1IlyWRbHGycjWQj4AdpFdi\\\\\\\\\\\\\\\/h9e3keB+nFqxznLwh94ZhdIT5JjI\\\\\\\\\\\\\\\/+84a9k5ZosQ1gwQx09gn2pJFGNDxhIbMb0EYbnpQ9cVzAAbRVrXTm5IsM6dRts0zwjEuwCYOHwu\\\\\\\\\\\\\\\/864OUDyHG9Zs59peD6ja3j8hlKVU8Wk5vMJ+FtK0Uwhqqe6QHIDWl5SQ64xMHVb29Q9Ct83XW7\\\\\\\\\\\\\\\/7AwTeYvXSkfhB8yetuf3Ywq7fUdqVjCUD6sjvv66yZH9BYQeykR14kJ4A0Lcvmc7NtLfNyInv5yfXO0AgkYDRmlCBom3z+eYD4SbgcKA8YO7zYYsSZkN8aVB9Y7+KFcN5b7Ski7Y89k5KFlW8rhtlF\\\\\\\\\\\\\\\/3N+CanCf4dPOTi6YgN5A06Nmg\\\\\\\\\\\\\\\/4Mf8yXY+MQrclweFywiwkVIXOh9rpybHJLrKxSrE38XrBulW8fGiUdbfvtpO4Nf9z6\\\\\\\\\\\\\\\/0vlJYuTIqxwCl0XmH4vo+WlJMjYigdeDJE\\\\\\\\\\\\\\\/MUfwLu+60T4LNQ7JfN5yvDCQBx\\\\\\\\\\\\\\\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\\\\\\\\\\\\\\\/sMXNHqoZLmlV8+hXLoJy2FMQDseaE1zhGDznG1g115H19fxehiaVA0UbO4qvce5Iy89xtj4WgCkvJKl8qrqi\\\\\\\\\\\\\\\/yLb2rMUBwsI6P0TJiMDbTMhi6vdKTW878DEU\\\\\\\\\\\\\\\/vv+1EJmFQdaSzUMpjn61sGGmbAoiBNrWaYw3sREJtLj8ynO8AorCCZgJxVw2tQiVRLnikw9yutUbJ2ate1rQ\\\\\\\\\\\\\\\/AM\\\\\\\\\\\\\\\/mVubjCCt6TFgfvEm9s4Oq4Z1vgy\\\\\\\\\\\\\\\/GstDQzQM262otjMkslFBxP4SUNe4VbMWn1gSF9EI0duMp5WN\\\\\\\\\\\\\\\/O8wzLabew1ETHwsCbyskAqZqh3P8R7YwC9XxXIUPwEE\\\\\\\\\\\\\\\/E38VO9GRdlE4OvWIqUJzjLuoEDMFQnL1lVkM+mZYjME3\\\\\\\\\\\\\\\/CskKoPHBZ0JZ\\\\\\\\\\\\\\\/csz5VYqzYqj1MBX8\\\\\\\\\\\\\\\/tv2KZTtdV4mbQ3YdTjAqnHtqrhzcUD0jGBLH+2+hYJhJm3Nm5ieze7dHC1I+juTeS4rI8oMHN3H0KV+9j+ZVVIb0ZKtbpYSr9c9tXRCvk3SDjoFKEObuU4mUqZHZEHaDzea0nN2DWwBWd7oAX0AzoVLc7le6lfJna0uN6oMJmdt37oIMwtfkq9BDTp6QMYkVxxHUU\\\\\\\\\\\\\\\/YeJSa6C2nvu452GoQR6JVx2WJqmRTY2NFya7Q2jr2AqirfH8nKrF2BScs1E5EDBwDS0Y\\\\\\\\\\\\\\\/a46wgTe\\\\\\\\\\\\\\\/urmJvvyA8EfrMCkvVTdwKfldPXwbFJUyeX4cG+0N4S61WkJL+V5o3y0=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022dyM1uVW8FCiECpjlHWdXvQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022fee89b77a886aef0bb9fcd3b4bcaf9ffaf2b0daa0b034f845ede5c78e388b228\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/96.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/96.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0405-z\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0405-z\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0405-z\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}