{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Rvi5VnvEp2Kr8P2lwi5MYR7hIs2lZzscx3bsVq4\\\\\\\\\\\\\\\/MZr41JJ1xVt2kYjKjUX6Vrcz7ZeMYCDaMoX65gs4FSXWKoYSCiuSkDJroeKu446cUbjr\\\\\\\\\\\\\\\/RYGJbACyb2ORiAknS0JUOKHIyU4S5KYpGQdVAW4gB\\\\\\\\\\\\\\\/dSGUB1pSPep8O7QunuGtGMbkrRpvptzE+cTjdsOnAoR5er5oSx75MF23HRxbAXO0NZqyD5dciBvs\\\\\\\\\\\\\\\/yf5K9YemsJIvI2peUyJcfPG1ZGMiC7SFe7vdJO8Sg+iozy+mNRvlhxRr5MluRijTBh1nKtXbl\\\\\\\\\\\\\\\/JNL2nxLcPSr1nyC7tv75wp6rJhuWey5PvqG++bMgFQvJRLsRatZOcYnneNNjPeTBRwfiCjhFFtZvE0BPUlJHRwjGX13xyWzizuU6\\\\\\\\\\\\\\\/MUjSrP037kzWDhJe+tjIQ3+uRZxov6ye2iSrWb61ImdcVpFW5pHBPV38FBKNcNp3Uez39ntyfEsTgUvEWLFka3SD5vhhQpLCbFVr+BPy4rChLANsquOAPVdLYxcBxoj8hGykQ0bg\\\\\\\\\\\\\\\/yl2deVua+VBrzTPFhywD3W4KzKzFarWe6vcX66O1bb3gkhp1G86lBezDJurcF9TfV8vNdN\\\\\\\\\\\\\\\/fwLgElGTOo5GzQfE8TJm4VR3ImBS\\\\\\\\\\\\\\\/Gers\\\\\\\\\\\\\\\/ho9GePP6ulk+\\\\\\\\\\\\\\\/tQHE9BwfI\\\\\\\\\\\\\\\/w9fPzkvdL7ZuLKTp670hC99pMHKJoj0Ej5xmO4c53cRd7xviEH\\\\\\\\\\\\\\\/MRFV9eosphHbxLwbZwmX87PMlCAhrtXZ\\\\\\\\\\\\\\\/kbPaiKDxLzhTj3NKynxQMBggVKemYY5UPxqvUKmwyc5gvTiByQuh18kSpdcDX\\\\\\\\\\\\\\\/e96eXBICvFLdFTzouwU+G1a9JZaycBhiZIoS4+pXUW5aKF12Z7O9KBm3x\\\\\\\\\\\\\\\/XLwyAE\\\\\\\\\\\\\\\/ui18MyBi7le9jb5\\\\\\\\\\\\\\\/TC9e1sECSDi8Z31czwBNudLUSjgURegmAyrqwV4IrtuKTlwqukXa0AEU0h3ArJNOXvDjpmxplja3LNz8MdulR623czW360P26Bi0d1K16mKR2hOM6rOqQEXnlI8az0Io4YprOsdERs\\\\\\\\\\\\\\\/FzL6zE7X9t8c4ONHZcVdAGZbYbrRjji5D1z7ykP\\\\\\\\\\\\\\\/xjZnmFbxs1BxFo+M889YK7pnPH\\\\\\\\\\\\\\\/K9bW+3Q4dEPiuNrzl61vPvWN9ULaLJib8nkIy1nPIFaV\\\\\\\\\\\\\\\/mlj8agUceYMy6Z0pxw9i0uwUA+l27IG9\\\\\\\\\\\\\\\/ABra0EjO0KsA5htHZJGGtQY4JAFjCv9juuuUuM7GPz3MUUPaB0zKO+qoP7qggwJwF4oArPJhKhmFXC6eUuqfiJL6vvQGbG9cOQ0zwo4\\\\\\\\\\\\\\\/qlZ3FCiXBHkYRiifneJhCV2+lFJnpxlVJQPQczOu89OjwJ0ebuNANrrF8hqsM\\\\\\\\\\\\\\\/G\\\\\\\\\\\\\\\/PQQywmJ2dyKE2dsADiKhy7kudtX8NYzVLJjk2JysdrC1s32IcodwFQM4jQInv8g2nBkGksfLNyIeLU703UFJdFee8mXZKhmE8rbozpHl8GOac25ldjd3LpDLQ74uP81rAJQhjVi2MTMGH5INJSsRSUOf9Qb2NmyAq8Y045y8HPDagVv3qtXyOU6hMaRb39zE+GSLf3H2KAPqBa6lau65\\\\\\\\\\\\\\\/P9NehRg7tsvkyZ\\\\\\\\\\\\\\\/X61lcPEig6D42tl7tzmYbugS3YcHU90zc2CDiLzDE\\\\\\\\\\\\\\\/1ad42uEz+pmuih4v1QvpUOG4gbjim8sAiGzwQ9uXDz2MjG4o1nxgfFPWyVatc8gm0bczS2fuThaSWwXXVVKsIaCk1lyXfLq9NFpX1YJew9l2hSUewjDfTXVpjSBYow8\\\\\\\\\\\\\\\/a+1Xal+eSZiyiQzeSaLv9Buwi1AZtarYtclvnvZkN96MRbZDZv5pdayGc88TOKVJriEpMQOykoPZoj6JPXLhOyXFXy1hoJOdSbZv4qNdWGKaU0qelbhkSCEtxPIVsc9bICHlC1YsH\\\\\\\\\\\\\\\/kSv9K5Ai2wEaJsBGFWM7QrJwAim1nqCQNrJAx2FkR8D0FW+uqVEsvbZLoPuchO0UQF316HmQR3IeUn\\\\\\\\\\\\\\\/KmrgK0fTqjwKMetgO3niZ1WpmZZfRRZ4ElnNi5vHSNsa3uzzQDZ9rtWboPjK\\\\\\\\\\\\\\\/+R1MqDbg6txWAvH7J5zjhvlcs+fMaDOwyuQJPN1\\\\\\\\\\\\\\\/btT6Fr3bUxcif7tWOtCzzOlbbabYKO0XPZk2JzMC2Uo\\\\\\\\\\\\\\\/TWPD9Mr62cJ3QyYsYZr1RjeCHNSnNHKCPkRqdmB66sQMEjsC8yAo7oHC7Z3j3VuA+yhqBr7ISpqqq6nrv8w\\\\\\\\\\\\\\\/bVM3P2yd9Fmq8HgexeMafiMwRm+sMDikqJtsovkii514+ezhStydxyIy1rMq2bMd7df4L2qdfJ3Pq58Su1bfz6g6yrHeIClmEo0J\\\\\\\\\\\\\\\/y2qWPSHsWxelYFnG0LFNZilf7ef42DH3kDj0IvlEUZbxlHNGNTTQf7KKE8lbk\\\\\\\\\\\\\\\/aSzhgRkDZmZ4Pj7Z8rUvuj6IiduiPfMlgCvNOIXoDgSZ3XhFoZ80Zmke4ar92sFha2AonRKq0y+wnkTtSYZMhjVzJIC9OTFHTdcsJtSwGw1cE5cFDig37z8XOzSHWTFvSl1ZTo8RCA831+kB+GTh\\\\\\\\\\\\\\\/42qeN7jcvn68I+GQy2bFjDRv\\\\\\\\\\\\\\\/l1HG\\\\\\\\\\\\\\\/vnucDjMpKn0ac\\\\\\\\\\\\\\\/61rBUWBN8EsjAFgfP6GqwGmIcyR3pvImysvQYIDVnDpKsrzgYozErFH0=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022wZ+J15dkFZhfap4NKQpmPA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022b4035316e6d99c3b98cb44c87dc39692ce009ca0854063d8ac8414fae9d8ac77\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/132.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/132.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0449-0\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0449-0\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0449-0\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}