{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022eoWI4AGQUgvISwBT8NDQH21X+nOeG5II3evXa+Yz3fkoVkYaUSm17plcbGKlyJ9ryTJHjPxFvp\\\\\\\\\\\\\\\/3MYUWZEpx3vIbjPGFscw86+VH25t472lhWA6WD4r\\\\\\\\\\\\\\\/z2XWnLh\\\\\\\\\\\\\\\/yUvv5qEqU4ow6yp6OHihgu5mCseaD8fUt7ehcqlMpE5f5i5EOzFLaH8PTqa9YuWke1SAjnZDBKa7YHtzYXnqXvWh7Hir0HA7vCahnLjL072b0DI3uC\\\\\\\\\\\\\\\/k3lX4TAIf7wPB60OZl+xuLXcK+YpsDYW\\\\\\\\\\\\\\\/a03qr4FYZOMd3\\\\\\\\\\\\\\\/TT+LnGPSpRTOibRHSoFolruhLg56aFAq50a5lQBYn8OeyrLRU8ruXiwnP71dMXstJBK3JCS5rghHUwr7KsKPLJe29qtx5b4hYA\\\\\\\\\\\\\\\/7mOwDKKqRD6X7ge88p+MXkTnNrg7hNYpzpCFcjHD3JlJ0rpT5Vl2BQbYH+tN3pEhRmc1KRkXgQnkjV3I2jV7tj5M7lqYNiRHNL0bKUQD7oecFv7+UbCevb8hh9EhIUCqGOG5Nj6byg9yfv\\\\\\\\\\\\\\\/VB2FCk6jleyNtbhhnuFgbs5hTU5VowbmNVllU9VdqOV3dHJXFtIRlci0cODmaA9gNbDIulERKmD0fnO1gJQnThI3cj5vCTIxsFRTGgE\\\\\\\\\\\\\\\/YkOposJzWXDc8vGTln06vNUWjmB0g+hxsaN4xIU3nAlkJktDLNCecAYOSmDSd6+T2T8HkDZ\\\\\\\\\\\\\\\/pWEyCMYrn2XyMJ9bv5xn7CKAP4Ubr3vDkouv9Zn\\\\\\\\\\\\\\\/UbEa\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/QgfMp\\\\\\\\\\\\\\\/k\\\\\\\\\\\\\\\/BhkgG+VhyHHUo\\\\\\\\\\\\\\\/4PjRAflZLQVQ4LaCZj3nhhgSYmMckAtRXlE9qfTu0J1QJ7EbgGCtx\\\\\\\\\\\\\\\/GjApVP8vqArnQX+AmXyQLi2h+dGmWhe9YXYwieI0ZsK+xzvPRS8NpM+RITRtgXNN30oFp9MPqMzAVvpvQa3K7RKRNgXCzvZnXUl8H9ZRa940Ubm\\\\\\\\\\\\\\\/HWmk6\\\\\\\\\\\\\\\/Wr9lFoy7iMn1dl4x3XJh1CVmq7AJsy2bu2RHfxx443LgZ6cUWKqEjbdCvoFAkzFFMnQA\\\\\\\\\\\\\\\/DASQO4+iG2mIkWiTcYR7eRp3OEP2\\\\\\\\\\\\\\\/21qwRX+JDTK7yoUnOlcp+p4HluauP\\\\\\\\\\\\\\\/aTEvvBLxdZqqUytFzGLN1iW5npjUu9RZjT8+F27GptnOczdfu3z0EOdjZX5ozd0Wh16d2wBJpXUq2Alf39LfGSer335BhFNUTm6rTiy6MDjIuxrXRRABQRShdbUSHiEDOBOd\\\\\\\\\\\\\\\/I5t6htGVSAmx5AePjmKVCm3ZJ8nS+d3j+YTpwHvFMjcnY6pRNYR5e7IxNsM8et\\\\\\\\\\\\\\\/CBMjYiXeLSHPS\\\\\\\\\\\\\\\/bk3vFJP0YOD\\\\\\\\\\\\\\\/CVsmyAEcZFwNHJtWKXLBGTkFZJ4WS3VqwGiiKPfhSVa1O7nKNE2gSMwN0IQp2KebeivGoCOvEseunu28W\\\\\\\\\\\\\\\/ml4\\\\\\\\\\\\\\\/pc\\\\\\\\\\\\\\\/tNw105qRRYkN0ajRVAamxzivuoa\\\\\\\\\\\\\\\/FXUkBOFEQpCvX0W1x\\\\\\\\\\\\\\\/gNJ+47GQiqGAoM3j\\\\\\\\\\\\\\\/e2hzssfw99AnLNxHVoFmlAqNzn4QCmmjqhamyWRTwKGiDeQcNZET7k7yUihN7AfLaJdlJckvWXKNrfXYgQ\\\\\\\\\\\\\\\/ZBS28iNMBB7Fq4G3aDGwhpysfQpHzcyJnd6YdPcNEuXBhU6YNwRCDcbU\\\\\\\\\\\\\\\/UBNHtfN+T4PyL1ib+aqaSuF2+IXl1ukDutXWZH9neMBQY8ZEf+h4oprE374JKm9ev0ZrzT71uUUk+GNKqBIlI0Co9yYsNspY+zy6dGhmd\\\\\\\\\\\\\\\/T6rwsxk0fwIdP4mJakltutxkyh8XEmqtkujZ\\\\\\\\\\\\\\\/45SCXlDo3hF\\\\\\\\\\\\\\\/KO0\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/wtM6OBJWkKKM2elezX6LVhM+ohj3k3CK9oCbTSHD\\\\\\\\\\\\\\\/ZaUbiUwWfZMDbXfJ4\\\\\\\\\\\\\\\/viA2R7Czqg\\\\\\\\\\\\\\\/CG8GI\\\\\\\\\\\\\\\/HVUqoUpNQia3jc7qgJ9zomQTH7HzuTsdzpO6coLsh0i+0QyakVFIVC1dpF6IPQ3dPlKaD1Y1OfG7gqNL9+8SG7VaYdT8Sq2pRhtPplpupTqZZ5Z9xKVI8sttBjq5eIH3otutug7i8DBDVKjp4ynACj4kAKlf5o2PX4YP8ezIaUzdIAccYUNiy8zDmLJmaFBQeuK7vrkyrJXZRzLS27qltHcTx7vX8iqiAR7sjEAbdRiY18Ci76V1m6dn4U6B4AYrGFhejETmlCumNZztcDOdWIyMQj3CeAhDZpHbZspM0b7IPLF1ma9gqjZQh5kAk3KpmyNi85\\\\\\\\\\\\\\\/8YFxtzZa3xSGCe9j0kIu9p97TOvzfgHRPzwk3qkC0cYPsRhskpHpO6+HjFXpg+YdMZ3YxjQy88IG3YdbY6NLHmLpwmYeBMjHaERHgg7Sphs8w9YnCt\\\\\\\\\\\\\\\/vgDlz7C\\\\\\\\\\\\\\\/s1CZ9XvGnwkoPSArvv7fzdRCYFUTlhW6YcLXllG+BwE\\\\\\\\\\\\\\\/5cqo+BQBsoIZqD6leex60mazIx2YREd+\\\\\\\\\\\\\\\/VXOyq7uJSn\\\\\\\\\\\\\\\/l7cIIJOBmyh4WzylVlsYUeNCHOR5dt9cCjMOUm+gN9w+sPF3v4nhws6MXrZkN2tqDDh3tqGYQufXx1xrBYzcXlI5QBiVjPcNSDFWPKohResBgPD\\\\\\\\\\\\\\\/QPTd7nTPXQH3XKbySuxSfF0UjQLuO8ZULOhmYu+Jg\\\\\\\\\\\\\\\/L3cdyMq5xoEmm+4DZE6k5gPdgP9MZqNuCFWny9kcGv0m3gYpv8xqOQIwj527cqitikofNEyFtwdOd+3wPIFgf6ekc=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022B6RgEckcrI2qXgbQiDHSBg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002270233ccc4b140896611b0414fba55a30680a8fc5d487ba1a51dea846822a05ed\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/2.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/2.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-017-0309-3\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-017-0309-3\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-017-0309-3\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}