{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022pfLJloHY1utoyQ3DA0YF29qWv42SZ+YQ8vsnyaK\\\\\\\\\\\\\\\/5YfLasIo3XVs14qmFsO+uP\\\\\\\\\\\\\\\/UqCcYNpl6Zg\\\\\\\\\\\\\\\/imbkchPR4kj\\\\\\\\\\\\\\\/VzFxvVNfAjMtzblIpYoC9OTizCMayh7pf67c8oDRcrHBhU5fRm9iM4i8YwCvzljV2mueJnNenLclAVPEzlAHvI4JSi6OLI7tPX4A0KEwHKmb2dgdcCPDs7Lw4PcS2bKDhPd07iyu9Lay1oljA72O4btwOFY8Dc2lONpAje1bhGX16zDMhx8iudtdQqRZAW8VprboNV0ihiO1t6ANVy8t3S8F2PpNr1YKg9kCNQKhf\\\\\\\\\\\\\\\/djG8US6xzTWZhlE6e0otAQ8FWiXfc01WGuPTpiU2iTRzIYsK\\\\\\\\\\\\\\\/iBENADyURKUbRZztNlyKh202NrjKtPikot7xfrCyC\\\\\\\\\\\\\\\/TRYe8GtP\\\\\\\\\\\\\\\/Jhrv4nTYBxq63ZyHIgK3bIuyp4z8WCdfA0yCTATsJ51jcs3jJZuQjg4fxXtzrhMpul9AKzJuIQoMUgmx0gkLJjcW7SSbJuJVVgEKsvS5gyM6nKUhCas37+bb+pTKvgih8Z5gyEUiQVZSwt4ctKDBbVaz4kjTp6Glue5v6IOiJTRUBwuFAlvFv00PrJZLnf3HYnGKoHeTnsicRwemUipfFeU6QOQbyrzAaGlvV5dQRhVZLe3XNUJ12HlsmzQGRPDCmKi1SDmGulh8oMPV\\\\\\\\\\\\\\\/SPeGnX219vgxNSlOqJHD02HANReNjaNEXiM4FOi1bN66r6AwpUCnancu6Wc09116en0ILgVVPQgVy1cBjvp8FQDfeTuKxV7cuBZwIlnv3qe\\\\\\\\\\\\\\\/0Xt0QUhbNMhoJ\\\\\\\\\\\\\\\/VqF+RN5k1AYo+uBzW7GnKXP9KRGT1b5+hBovFtcENcu07Z79+lQTIrNHKpAAf77uU651QpKKWTLb87qlThaH5T8uGO6BOgMzMOYVMT\\\\\\\\\\\\\\\/rNt3jEeFIXfi0\\\\\\\\\\\\\\\/ZkxvncFf22eFBzwCKm9k+4pvjRuahYidQDEPanbf7U8OkER3P6Sx7zMb2ezKFHynkYHJbyn3+ZFkZlM4Rqf7oMsLQwuAyPkGdFMdrIGPb916CcW5AQ1upJqQetKR+wWLB9EpwLN3Yv0784MZXiVVgx3\\\\\\\\\\\\\\\/PIY4GRzqUTbFbwAkeH6ai8blXSzgTgE4TiLNS9NwNSKFpiiygTVd1v5+XXkHpUH\\\\\\\\\\\\\\\/m21v2mXDog2aL+5kRZQ6jMLhC97QQfJL37NmqwPNgwj9WdpXT6e7Ee7fYikol9Ww7vmjtJEf9YF+\\\\\\\\\\\\\\\/7N6h3ldOR527nra43v6totEDSbLbZNtvS0MgdszGNPc0ND0gYiKJRdfsOj2l8Qu3db4bpem+A6ax3ywyj9gp8uAbxK56\\\\\\\\\\\\\\\/ETKIaIttN\\\\\\\\\\\\\\\/QQY624SWwewBMuqP+Q5GWCbtFM8l3xsPSdVyGvcgLBcRN2Fy7OzuOQuo82JDfBQMp5JiBs6yHR7j8mmkC8ec8+KB2A1ooRudh3inPa5nD+k\\\\\\\\\\\\\\\/lq+wAbtEfwL+QZAopenpr0H+vmHzTArYeDH608PHbAb\\\\\\\\\\\\\\\/P4iUw5CbJsVm0cEGQo2NNgOepGH\\\\\\\\\\\\\\\/AOWQzIsMJ4nakJmV5rGjTiPJox7F\\\\\\\\\\\\\\\/hE9aWhBXfCNkLT2b150SvXJbiWzT\\\\\\\\\\\\\\\/+JLHXFs\\\\\\\\\\\\\\\/sqFB4D01kftg\\\\\\\\\\\\\\\/gMItZK9WJX0Oqg7XBLR0eB5I9\\\\\\\\\\\\\\\/E0kZd09D00xFcF9Rg8OsJMaWzfeEX2d3TuJ6oOQiVN1wr9y5Qq35b4kyEgRveBQx5EPdv8OCgi0SHHJsmYFZ23ZwH7mG4ORlm4bp9gYPxN2DMJIRIa\\\\\\\\\\\\\\\/HNY2VxoAxtf2mp+\\\\\\\\\\\\\\\/ACY5XojB6ZZFwPRdHfPq3ZvwxB6jI0DI7dxD\\\\\\\\\\\\\\\/klcbcx\\\\\\\\\\\\\\\/x+nEsMcCEhTl4qP1ekgGFz40Z7XkZgkQyuZI+UhtAephZ\\\\\\\\\\\\\\\/VwyLs0IlMl+0xyu6LXM6D18mP8PY5TbR5S34z0f7BeiF29cIy2XpRlQ2KScwK+UaqAF4zf9qDXAoagyAdRDnrdYZPAiLJDj5Z005NRvVH1X4ute+nGRmV\\\\\\\\\\\\\\\/RUmQPgLyqSGPy9qqzIHH6vc7QgbhfuctEHO67ZkkIQaLqJm7RqZIYx1BSac79Ij3Zo5M5waNodLbeyXa5OhCvw8M+My8Tpk7jNsKp1fntm83AhndY4fNYp6mAv8oTZ5MFgmCyTru1A3e2wIIWlJsPgZNwQpXq+L7KYUX7kLSvnn1PMnuWW3BJeDsavIFsnSTOJTJ1bSyXPD3stbXeDXXQQHB8EyV3sLKfzDcuz5VLOg+wPL2xX9U4Fh6lFv+sm5eOP+WSmeUpoQTYQZIcDTwf+WOGs5k1kJHEGAx\\\\\\\\\\\\\\\/GtN7IxIZ3OMWsyL\\\\\\\\\\\\\\\/S0\\\\\\\\\\\\\\\/JnPS\\\\\\\\\\\\\\\/6ANXazgFIOOH6eidvSLHxHwgNwZuI+OVzwtKm2tnY1HJMg6Gte8NqB+\\\\\\\\\\\\\\\/3pPeWHlr8I7D16Ua+EcowyBRUsUHFW\\\\\\\\\\\\\\\/1Pb3oU1O5ieiw0SxvtttbFVF3E3BXlfcgjMZO5JSb3FhEpK7MRKKwA2R\\\\\\\\\\\\\\\/STnDa0ib8uFYoGPyRFATho9kczWG0YxZTZyTfO3jfU2EuqSnSui4B5sPjfmGbEgQmmQxtBzwyx\\\\\\\\\\\\\\\/FgrlELQz5GSNNNYinMA0uZXopu+FI4OZ3LDFYMu3slbyp7knqRCbI5\\\\\\\\\\\\\\\/f6wsBr8ft4pZORoHXXsZs5wKJXNi5D3KV\\\\\\\\\\\\\\\/xwebzsniIUVgUZiBeMzNZleZE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022U5sBWFxeBuYR7ydbdH+J+A==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00227dcd8e8a9b30f08f0e3dd5afab7b27f4bb08d12b451444fe4d60971abd7d534d\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/104.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/104.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0417-8\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0417-8\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0417-8\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}