{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00221x7Un57oQ4GvEM\\\\\\\\\\\\\\\/wOFyUSvU428XheAMKC02WdkdUd47NfQP+gnjhmmiTPaRz+rw7fxTP8danzmXmhfy6hKZEH86fs2ey2qDqP\\\\\\\\\\\\\\\/HQAdfXozf6uIOpJar6\\\\\\\\\\\\\\\/uGbYHPDxAGO7FiPhbU1eyj0Dj\\\\\\\\\\\\\\\/7XS5F1MWmwUKNhDnd7BnHqp959RIBEa3tTqVbvRhAbtvsiFwq7bGn9Sy3+xwKAgQb7PTy8VIxiD9TzTTojvqllxBgNCkLWenG076trI8Xmr8wFp85QnR6v07ElGC5pVzNqIRrwrURn0tkxxHcYCmqlE0pl5jZQkfvUHLcdDomROPeROHdB3fbk7u\\\\\\\\\\\\\\\/Ah0AeYyy47++SSU98uKLd2Ojt11rf1cQisavdDMOn86BOqCysTcT4imapkSRvJUQ55Ks3aFt867A8xyraG\\\\\\\\\\\\\\\/o2VGIQmkonf0YgP\\\\\\\\\\\\\\\/z3s3gu9lzMoL9Dj+ripfbdAZ94w0swj5HzzdeQL2K3rRtkHIHP3FLCzMcOLtkobwTZD4aihtpb13mzh05Fy4\\\\\\\\\\\\\\\/BIJO9VIpA06ZbhIJLipaDx4VSrQvgpNGH7M1rZLLlX20tutYOGUVcHlY8M6Vri7IwXEaaKo5qxD22AM8XhX7Teiz5+CJsw6bUjgMzLWO4qN\\\\\\\\\\\\\\\/VmcGIDpq6iIBHO9WrCspvQyKtlxc0po8sND2YLSPBUck3a1\\\\\\\\\\\\\\\/2AwLzxuI6ZpyNOia6MhKz4GX2iheOnsHMgztILBJDtN3yLOmiQNhTkxvTr9YABCEIIpEMq0ui4Yr4ykIwg\\\\\\\\\\\\\\\/zNd1X5FOrulkrkG8yp+nqj0T87L7dIfvYvsuOINvXSgQOmtMhVu+5UGCPthbJaqazjPVVsJPaOvemQQzzvf5eRNifujjxH\\\\\\\\\\\\\\\/CRRs1GDIGTkeCdho8LtuPU2zEpWt7plPt3Vd9cDQ+dgj6l9Kpc3UkDIV5T6bvQ+z3Q8UTjI992pymKeJvLYauZjsgtUuJQucBbqCNil4H0+d7yDyrnFq0rxUPuY6UnPi0aBZ2NXuaFNPOmGSL5\\\\\\\\\\\\\\\/zqNyExvQOeLxG3ry7rb+GiO0ZM16t4qoQNwGtIzQTvsNzeKUZ2KG2eT6KFXebs6zvU2E9s+n1X1xUcsnYI4CVIAv2X8\\\\\\\\\\\\\\\/fRULBACBncP1\\\\\\\\\\\\\\\/nPEj4SbMCYOgXeqHxrsuhfY2hhEm5EQeqekqtoz8Tt640f2PQp28JrD8V6tSMb2i7\\\\\\\\\\\\\\\/DMJ3\\\\\\\\\\\\\\\/NZiKY8bMPshQ\\\\\\\\\\\\\\\/v\\\\\\\\\\\\\\\/59T05BNfH8Yg+90wsCrtPqearTaa67\\\\\\\\\\\\\\\/D6hz1x5ecEH6AtuzG\\\\\\\\\\\\\\\/aydAMsJ33Jma5qYudnqD5bb97eW2hGCWoSVgqTqivx8WCQy75D66PSyuyVIF4mgRHCxgLIMfDKH0\\\\\\\\\\\\\\\/0on4Gv2k0xFtgvY4qQWp\\\\\\\\\\\\\\\/lY00cUeeYKyzepC9oEMWphNCjgEbQhQeJDFMowTSfJSiHOfAFVBl+v2q0LcONP\\\\\\\\\\\\\\\/13XA1PfFTXg1FjnUV4mYiu61Pa7rDAYdF7ewt7B+gYA22f4yVimDkflWwl+PL16\\\\\\\\\\\\\\\/oxbbSnOlbRHdU0BNSJTZPAg2ND2uq\\\\\\\\\\\\\\\/m\\\\\\\\\\\\\\\/T8wZAf8yT5dtN9x0nu6Gp5sB4d8vWeXP4pNXvrdSubk+nVrXUIaw9q1Nm+eZ5ZQ\\\\\\\\\\\\\\\/fNxfoQ9b1X5QS4Dnx8MgWwpqMLuxeGIMukiQ7K8kYurLwOMy0EILrOXOxc3H7uFYU9r92GnZlI0V9WchOQ0RL\\\\\\\\\\\\\\\/zc1yI9Wgh0dmOvPsx3bcAVTUX252yT83aL4NMMP2y0N0cql3fZr3n\\\\\\\\\\\\\\\/bWh8CCBfFcqcVVieLZsNxjX8H5Q99UkFxEc\\\\\\\\\\\\\\\/oyIfX6wieyJgbWGrB4pgRcB\\\\\\\\\\\\\\\/VaQfEdRMPOJCALyxW\\\\\\\\\\\\\\\/ttsLpM0WFDiNtGbAJ18IvGF\\\\\\\\\\\\\\\/LtC8WSHDNwIXRyWW4g5dKckUzKqtTdWBslDYJwEVATm7ldxp4D7cNmYZExZOUM3xjQlTLHBmkUi4uQjxSSFmbeNb028yEKpzniWIdZYp0LXsrcRdXnk3ptyjgc6UgmKPOyky\\\\\\\\\\\\\\\/mHyo8rsKqF6a1XYiJOo1N6sKI84LSDgvYYJX9Nnlt4AhtkET4ZQzTOub6MwNdN11iNEE3ra6Pq031X5SZJKzVRgWjIMifxidiMiu6W8pkP4PgwSTWjPJOV1lYTYjok3k3jkFJgdilZ500DS4Spwa3V6Wtfrdr6h0fNAMhEo5YRAS0Ft422kCBkOvwQfrmvmKIYeMY13mTSDhKCcu9DLJjfBlB\\\\\\\\\\\\\\\/xKwJFeTLaqbuqY1z3KUnzdKj4\\\\\\\\\\\\\\\/9Q4OjYsfoNUyDiS7EjOTkh7OFdFCCN99VkPfNoQjMfSwww0LYXO1t9C0Z8\\\\\\\\\\\\\\\/bJC5rzUYp1IqqT4S8bLZsK7WG0jKTFQ6\\\\\\\\\\\\\\\/rX33jEBcQif6or0VsuoMuZEJuY3h1\\\\\\\\\\\\\\\/8pJlFeqTdOlKGGnRvPH5Yo0K+OR2xiNSP7WkoeXPT8oZWSrH7SJGL1TyXvJ64fZ6ZGffFltUAaif8VPQ\\\\\\\\\\\\\\\/Wlp0YUMVTG\\\\\\\\\\\\\\\/5BqBRzkl0cDhbW1yEIGJPfl8jdP5PJ+L\\\\\\\\\\\\\\\/W0OA2wio9TlbU+AeZC4YujwBnp+gUzKV6ibkfDAcSCoD+yx8+uQGUYnm3ZHI8W2iv4oMhKeUY3YYhjdw+zmokHJPFbn4hQtm1CXGH4iLwH3+U+gdy\\\\\\\\\\\\\\\/psCQWt5sZix\\\\\\\\\\\\\\\/vUsahJZHaedqHwRNGogKafzH2UKX35s4Z0irgCcdIfHH7ClgqcaPS4TEE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00222rFaex85xglFrmNQ9p3QzQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002230e4c3e50dbfa81363e60b503e075c2397341ce5bed897326b188a12158c7b1d\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/69.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/69.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0377-z\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0377-z\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0377-z\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}