{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022fIGSaahp7rixKDKm3rcGmR1lvva5n7Du9t6dV3N4PRdKu\\\\\\\\\\\\\\\/QRc6hYlSs8HZBmgme2+9YrBw+QZoSNPiMOH8JvVKucLgsOIsU3YbxrKbB6UfMjikxLU4316V+38JmAYAgBZMY7AtnrikMZoFY9LHt68u8o2ArnykB17vlS6P0lFKfxlksZudgv2Kq+N2\\\\\\\\\\\\\\\/45biCPadC7SmeEFSgvb67H00jalKQS4rrnw7A0thbtf6pp\\\\\\\\\\\\\\\/QLByYwa6+G89+pxU7A2hmzpTU6BSnoICEzoilC7uzzCjBywMWo7AAmPNZpAJNtPKqgnwnuqMPVlsJAXFwBIyBptlTW\\\\\\\\\\\\\\\/bXo8Razgy0O8KqMS5X\\\\\\\\\\\\\\\/+PksowY\\\\\\\\\\\\\\\/oHJnvZGOM78i\\\\\\\\\\\\\\\/302SB7bOR4d6tDWPHJVN+gGgOlDU0QZvYCNeCQhtFEZpnufVVaKHAPjruyldcgJ338tTyTVXF0joZxLdN4i9nw+XoxOzpIJsyQ6hQi\\\\\\\\\\\\\\\/eCOUGBpLehZpVejcaalH6c7kBOdczNniCDapOzfvViulAser3ZEhhBWNpTiuEx+k68fILlg5599KigRzgY6m5HboM1mufzZME9B8xeMkJwr\\\\\\\\\\\\\\\/WfFM+3\\\\\\\\\\\\\\\/vPMyyZcY+L0WQ8+VVwcAc8lMBoXKwTPa026fxDtAff4FXm\\\\\\\\\\\\\\\/k4nvceMxWCiTM+6AA+cYPUHRz3Zc6hqOt9XrVmoZt\\\\\\\\\\\\\\\/XL2GrM0OXj4LWVUakM\\\\\\\\\\\\\\\/+GcCB1c551qeAo3CFt3WzlEUmfwMHV1F1MKHBFPFTzDE+G9m4COmymUdXwIrQshI+dYMZGzC0itSUEnX5cQT6IgpMoltb50L4zAL34LIcaMw5UBlblnwEne7qF9pNKld1vGBs9ut5M0LnCE1H1L\\\\\\\\\\\\\\\/2uMz7doI45tvnbFyApOeYROHvIgXPMb6gtMjrZ1MXL5Hj22ATcXMt8TrnpphRAietDKY3OcQzZm+dAIuTPwcO+qtt\\\\\\\\\\\\\\\/6DsbxDuGhcrDcyoHcBqSatO84fk5+GPdVQ7BYVVVQF9IfUPjqwtiTF\\\\\\\\\\\\\\\/Tj5cUnmV+HXMUoI2eu9gIwTxhFbXuzkM+3fbZpTn4YPA2MeihjmDwc3aUtv\\\\\\\\\\\\\\\/fM5RSuL+JO\\\\\\\\\\\\\\\/WhiDH1kRyMGJ5+3QonCfJ7mp3X\\\\\\\\\\\\\\\/7SaS1cEBlvVg8lGoBTdA4MHCdh0z++uvf28WYHZuEAlei237K2yHYgY09VpjlYM\\\\\\\\\\\\\\\/gj2S09lZL9bxJxU5w0tmR\\\\\\\\\\\\\\\/JW+XNdDwFQywj6pCxklgi5bhvpWTJpaxAOb772KA2mevJbYJOZKEfU0tN3nFMNVHm2ewoew7MhtlQbfsSuXIWPyxgTDZAvoAng+0ASSPyPXHR5+wIh44wHyt2GbjVL44sFlA\\\\\\\\\\\\\\\/tcxXmxM5eLrBYLorhjV8SbBNNhwKN1ZUq74TKQ820kS2l3AetBlVXQhg3LaRmpju\\\\\\\\\\\\\\\/+qdC6SyGKG1Ni+j7bwyL8khWDyP2M6Ou5Ophn0hNwVbxJc98JZE+xg\\\\\\\\\\\\\\\/zypFDXHhurDB2BxMoTpF\\\\\\\\\\\\\\\/wdeYqnZLg4oSc+9VIHTTjlBNwkVWA0+MGcvoEniNQ1dZ1fAx1ATCDTHWAjcez3XrvJDppYo9miuI7V01OCclTibpOmWBRasjyEP2\\\\\\\\\\\\\\\/OG0WZd7Y32HCmSDnmmYKaCb6svFWEruQpLxe+j8rUL1pNNddHylmNT9s1\\\\\\\\\\\\\\\/9Td\\\\\\\\\\\\\\\/yjeTit3d7VanQrUtqZd23dpTdWUYcNtzqHT3g164TqE8LSihE6hrjOPd+k9jWEV+zubJt+9hcZi1rrpT7VR72E3MPzEuVW5eb0TsviNk2eFZmHxO\\\\\\\\\\\\\\\/92bbNqZhIUd+XxQNDvXa1AXrWtrCLVSgiuK8VwZf5AbnXu1rUWywFl9Vcq8eImlUfzG0a8IxVvMmS+sFTaJzfdruEeAOZce3ekAjhyDsKNL+sJGZplTS8nd7nJ+t9qBb8c7TDcrOWyrhXBIUQl7aMKaf0zHpVs1Mzc6YP0jGtdkcO+7SvXfFit0DqfUC+1CgXGKsdIBB6iCde6YpOYXOhUgFbZWfED50AwgQnVPW5nnysLhm4Ct1fJDDHmN\\\\\\\\\\\\\\\/JWw8hfY8+jIp\\\\\\\\\\\\\\\/0TCvKFafkJ99BCmm+N0fg+U5UDQrorBKnq5hZCWdPe2+QKSH0owvxs8bxwmIhtxfgsDMrQRaJFd7RegYKGC0iFGn6yFD7EMfvE1pq+NVEQj\\\\\\\\\\\\\\\/bVJ85nr0dK2\\\\\\\\\\\\\\\/MIu8VgrklDJVFO5SgOJ5u5jsLfdMV9H1poZu3aT+6MGtsBC9OtLEZ4eO4KDlu7hUtudhocHTw\\\\\\\\\\\\\\\/7aiHMGhCzxcR4JBfdPiRHumFNxEr5qeDUOep\\\\\\\\\\\\\\\/vxoXYeqe+8aUeIMgJXPCQY+zRWn+F\\\\\\\\\\\\\\\/hGJ1yTR7Ddrcw\\\\\\\\\\\\\\\/WC6VPJ8ArVnyGGYhLUzEyGGsQ0iQ9ffdX2JfV\\\\\\\\\\\\\\\/StMs60Dw7OVvfVMv7YEzqzqLWXbCdXs+KDm6j5DZPIZdhVMzza7wFYvmdBCN1L2e8YclOkt1sU9FnRGk2bO8qGvZl04MI0jfIh8jjOAyzVcJ+QogcbHyKfyKtnIS4z+\\\\\\\\\\\\\\\/og50nutSLCXZ+nZN9f8uzACq3UXeh+6h+1JNjvIuc4Na9UkJHmtjhLwXxj2YgMrWHsEPpBZuUUzrLM9UXd32FxDGjh7W5tVSAOCabx5fLWkrM\\\\\\\\\\\\\\\/BDclewJzQDr037YKpCzQSpaoh0EGGWJDlneI4K83o2HJWJsNdU\\\\\\\\\\\\\\\/WbdqNEu5fr7ZWeAwfk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022KGB\\\\\\\\\\\\\\\/aTeGUybwomqhv5L1xw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022ca13e8f18f67e40c5d6cb82f11d41fcbfbb91af7e4167ea7786e74877a799bc3\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/59.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/59.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0374-2\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0374-2\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0374-2\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}