{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022y2cP5vyDW0lbdV1N\\\\\\\\\\\\\\\/qWGQm\\\\\\\\\\\\\\\/TySO9b8So344JT1piU\\\\\\\\\\\\\\\/VuISUZbS9gigVoLHZeBZ8I9zfoWFPB\\\\\\\\\\\\\\\/9L+544m5C0qjnsUeda4eJd++piFJXGlLa2qZ93v5LFIdnDFI0OHhzw8IIovHzrLLIKNKO4GNXqpAofuYUXLtOtnCloItazITPdmBSO5pyKJ\\\\\\\\\\\\\\\/MCnLkOLEsyS5Ce1+Pv2O43sC1164xrHMci70ah9pSm7ql2p8GsqlGt562HD74rk095zGfkN+iE9Ccql2a8Ch0ky48x7GMRw9cAj3dzW+zuNN1WUTTU2zqR5nbSauj3jR7l0uQncUICEw0b0aZlBjVxwVFAQEt16Rtw+++agEuvXa2Seww7b9ZSUDrAwBORHygo8TGj6QwB19jLJnnaG7\\\\\\\\\\\\\\\/A7VlZ3n0TXXsBH1aNDJicI+\\\\\\\\\\\\\\\/jhcmoP7OcjMfOntYez\\\\\\\\\\\\\\\/Zz5UfWZ2SwgwmWRqjoFVwyT50uxDwSBu2P1R7Fb9oSlRZLIWxA97O0FRTfNSDBv56Fx0rvUMKYUYvnrJoL+YterPI7iIOIE4pk1mm8WLYZcW9nCa1dpZq8GV4Y7vP5qKYiiUfEEpEYyACPrk+755stt1MaRXvkqHTFWpwuYQrrZ6Qt0vYNRKu1BmmzPArX8jLzItVV9Dbezi06XFF4VzKYBHV2lt96zdriBa+EbrKQ5Bton16asBWuI7Mx4Wb+Kqm7vBEuPsHcCFTxJjA4VY9H7MvSPiFEHcd6b7Y5oxmy\\\\\\\\\\\\\\\/soZG\\\\\\\\\\\\\\\/IYgJwMXH4HpcBEcaK6G9rIeLvZXcGKi+98HR51j\\\\\\\\\\\\\\\/23MmKMjhYWV\\\\\\\\\\\\\\\/ktbg\\\\\\\\\\\\\\\/t\\\\\\\\\\\\\\\/10YmuJmPVA6Wfp3uqPZLHX7JtMNih5KFv8BKMxqy+vgT9o6OLwMu8iLcTHECS+e0a59uqJiOLWxIPftv4PP\\\\\\\\\\\\\\\/+LEsl4+Fhc9G3m+2X+GB0ejXbs4jCWAqzDSzoCrpchqEKOW53fpVNRxsKtxFkMI7S0vWhqmJeGSPzPlJYyJsB1Ky93g4FvhmoBxqLoVjvCVz9FQvfpcmAhJxC+yxFtnlg8ICPcW6UUnfYl5Lscg3NaGE5RRp\\\\\\\\\\\\\\\/ECtYjfxAh83FysvYyiGvdFpXuawlEbeun7N6Uvluxfc3AvphVw7chkgb3xgOKcOrHXB75JJtrn+uhc0aEkpJGzh0U7s+62\\\\\\\\\\\\\\\/Vg\\\\\\\\\\\\\\\/QZHYHAGK6d+ZCcljGLO77cgU\\\\\\\\\\\\\\\/h8QdvVQFH7x0XolHlpMy10ba1xavxib6liSPfWrcW\\\\\\\\\\\\\\\/haL5hesRygU4WzJhO78DgwJggNSWlSLq8GT2JGYu1gcNJd3aUvpAgs84EmUCV0k\\\\\\\\\\\\\\\/GVEsz1wVbKuwqIdW8xEA+a5O8z+b24jDDJOUHNazyY347qPwBVgRpa0awxz8T8riMcLgesdfzbWtceD2ClJs0vvhee9LWQx6xpjMYvkYyWLnZcjqUkKktdmX+orbu1DKahpT2LdhJPhVhed1SItnhzj2UuIMRT2tJqYyztLxCwFTMnFToRYhDbYoGGKMC+bVLX\\\\\\\\\\\\\\\/PJ+XC72H9Mv7wj5OihnK+uIHIsFp7hskygr4dmjVPrD0oQfEIFmYSXn5k\\\\\\\\\\\\\\\/i31P1fdzLbFEQmkC+2BUfQUjyuRX18LWoCLZltBwgdhojcEuYtzEZcZOx\\\\\\\\\\\\\\\/aQe0NEVQYzHAFxb+iaerFKR3GXICUhYqbZ19jgBy5IcACdEFxvmbDOXuhlBu+keofHMUTY5qgu6vPZGxZyF4dpWJJ3KDMC\\\\\\\\\\\\\\\/IxZ7VOIVF7gQPKbm9a3zlsXDMFUFky+OQ6C42JiZoIkMAumF9jFj2cIFosVHIo8SUt\\\\\\\\\\\\\\\/vdHxx6XbEHYcGb+APtnfT6Bd9rfSsGWW4MQGRvceFZNhunj8lD2gyR720RVG\\\\\\\\\\\\\\\/O\\\\\\\\\\\\\\\/+Y\\\\\\\\\\\\\\\/SFQ3JTLxizqleP6FqtTPuIIs6sX4ABL6okK91rNyatZsIqxqcDrLNgtX7sFM6Tpg0z+QkA0zxeEFtP9TcPMHNuV3of75tdsDzQoSfjxVYu7fxZuPH36Qcn2srSRXEb35nYNMg3P\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/KYTGr0QhneX4mv18fnypKHSsghioHFPeM7wGBy\\\\\\\\\\\\\\\/aqE8+BMQTUaSP9XBbFfhXW6sEKsgXj9qO0lhrWBcQG+tJ+se1XMbRLibX88yAjpnk0RUYyBbcAtpvR0uY2LwPuqZEEbUc8cmSU0jLLrPHge76XinHw7q9JzlYyDL8eyJcsTQkaptLkntEmkLZQAK8vfdaixURBdab8v1byOSWRgdXRGZfIXi\\\\\\\\\\\\\\\/ECIS4N5EjMWKtyoWzCG4YnhLoV2kWpLWLNiZx84xwWIwYkZ7+JkhktuQ+rfDbyGaNP9pp\\\\\\\\\\\\\\\/h7pmEP9P9omru7rSHVK5zzv8SGctevqyK+EPAzHHDiMzl1hz2wfTou+tU5xm3HieoveiPTjqpFaB3QRjblDAqYeIvN4LaLxIkZ83dtG\\\\\\\\\\\\\\\/uxl3YPPrmrkLq\\\\\\\\\\\\\\\/4JYUyYMb6L9IIh8yxja9Nim17QGrEIkhMAyB+p6CBu+OBMhYd0U3H5F\\\\\\\\\\\\\\\/UaApjL+Hs0\\\\\\\\\\\\\\\/T9YDBX1KYbX9hfs7N6bdX4QJ9myAwOOq0Y6Q\\\\\\\\\\\\\\\/Sp8xQm59DwsAnBmuRH5eTQiKQY7HPx6rKH+G8ZBosMvFvqX0hD8b8FGqnp4+LSRuyzyZpv7kutYSuc\\\\\\\\\\\\\\\/3n34mcMcGM95xXG0opWvwSI0anZZu+Vi8iGMmLZx\\\\\\\\\\\\\\\/YNrnlZ9dNogg1hx8RbU+AXmcE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022\\\\\\\\\\\\\\\/rIXTu\\\\\\\\\\\\\\\/RKvDdqMUCXKpGqw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022c3593ddf3d89d772074e982adb8f8f623a8c2bd115c94454de83c8712a85492e\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/59.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/59.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0374-2\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0374-2\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0374-2\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}