{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022\\\\\\\\\\\\\\\/91aRMFA8ddTBcXcZzALzo1yQITdQAcv77mQws7OW7WLmw5lXHzAkRz4L4+FN1dvSDfXaDTltl3G8D3OUIEbSxHAKG8RTyTkB+zrdxgc0nInZWUTm8nF4FhG6wepKr5S1TmByiNItJLO26ChkRqs67gDVvLpSRK9KUtKHl9aF4uDk5OpEG3Cqwxg7AqiYHWTmul8MxOiFcKSuwN93wkpQWRViPaoBlQQiqxgCD8XrHXDGnDBo6CaV8vyWeMypbnC27QR\\\\\\\\\\\\\\\/9bURDnxg9yQ8HKQH2aNwcsfSCFlOAMKrrK0sHpIYRpDHz0g9BdWOGeNicNFsfvde\\\\\\\\\\\\\\\/i492gXlOGparrOl+hIdhsw+fb5ZgJk2mwO4HTsci3O4DUP2766igYpvN+I290MZ746PMW+l8+tgj2\\\\\\\\\\\\\\\/wxmuI29nh+9AE7BEfOSC4v2xPsMw0GdjI7RYbU41YeaojGSx2xb3w937I2IZzRvlglDIB7hCIIuunvl1Cfwoe5zavV\\\\\\\\\\\\\\\/aSqtoTdsw3NJL47w1OOhApvdtKVvQKI1QFO464LHo7WxojA+eWXDhoFdmAR2+RdtOMv+a1IXIONZIlVACgeuRUbDAFP+xYk9wfygzMWZ+iIVni\\\\\\\\\\\\\\\/Prh2VhZEmquNtUIXYj1+1zSUDSsj2yIHxxaE7XmEHazhMY70UCnz5rdH5E7FU5oeMVFbTcmY8cBrYkte7Bih+1VUNybm9XYbM6ZDOvZbQ3UESS\\\\\\\\\\\\\\\/pGhBFA08EFEC8avwzMC1wrlB27rphfXTnDYfW5zmydUiYKfC5nfLOYTdvr6EA\\\\\\\\\\\\\\\/ae+9rFIpvAAqwOjxB\\\\\\\\\\\\\\\/hBoIU0ZkmoISG0ezTra63NZGgDzGnYu9hw6dAtSRfIDdWm0A+66QOPNlSOFzNwX4FJMGSSyl6DDiRynVAi2GmdtI9sNgrffa3ppDGJCtetPApyIBuOL+91fn7qSZZz\\\\\\\\\\\\\\\/NlgBbXKuUKk8Ek2QwrledCuwhDbidivyljUYA9IeY+KZUiKuJ0y+d6CSavPBePw1z9Nj4Ay8y1vVsgpfVgjyfpn6SGH2eRcYbG1q\\\\\\\\\\\\\\\/dPRqRyToW1y+vjN4nr7ttrJQ5e7CXhreQEkvzdt9tbPY3w6Oz7pta7VRHSJznLgMGImioCRFFQkVR1MUllXhjTOKFu4PmFuvkvQHA5IzxWoiRtgLyeIInHl4LTTb+V9ZkXO5zc3VvF6xsmEAOoFbLxTSkvJAxk4TkO+OUg9K4XryrVGKAx7DhGg+7TVAfQqbxmHBV6df9acTP9dBwfc0kDA91ptoCf0YPCzVMS6oWKoyuDZYVTKsWEu1Wv\\\\\\\\\\\\\\\/veXf8957PvTgy7ittwpho5WM1UCtVRHV01DmOt1cyuyoXiUknY8JGBjRsiSK8vIThZxt8bmj1FtM99IKa9G7Fg9anhlBhxA3szWYcC45M9xKhbrUJqXlMAZP4GP9PZ7jhHLY884\\\\\\\\\\\\\\\/mkMNbTrwRQRLHoysBXQ175IB\\\\\\\\\\\\\\\/Bd\\\\\\\\\\\\\\\/pFB0SBcFNF+UKTrgNfxIRZDefgV6fKVq7nmX7x6IbnI9CdhA5Dqn8cbYwGyH7UXAbcwpkYKiprg+gI30T6g3eaqkMVu5vlXy9LcoV5iCEFzlans1T7tAJqm9wdpqpAJgTihbTUbTlDqP\\\\\\\\\\\\\\\/GJHEKLaO8l1\\\\\\\\\\\\\\\/jiu4ptjunubb2M1+rWjucQ1Hnpwnw19XAUJrFMHVYOBYFh16WyjlxCsWw\\\\\\\\\\\\\\\/nRnZyWtZZ6SV4GpaSFCfgZWtXyhHxUfKpRK2vZGhNsQXH\\\\\\\\\\\\\\\/KWwlODC50wFNvnMY8fXrpbi93xGnQhVKP7Cr7mR3LUqxKFbozUzy5ZwycF0MSUkxzQ22smdOBSf\\\\\\\\\\\\\\\/403VCOBPTeLSz5xdEB7BKo1r7XCC9KZ\\\\\\\\\\\\\\\/URssk4Q9X3i5e6xhVaf+nSiYsrf6+chKiWHqYIESbJSnAIUcjhEHZeKpwuY83kxT\\\\\\\\\\\\\\\/KeR36eDUi+s3mBneavI3pbIw0HeGkMtgvZ939h8MrxwBNXyofXECVDJIZ19SzkwcSXe2\\\\\\\\\\\\\\\/uqQvjpCkSwMuo5LZMoQTP77nq6SxF3AFjSaWLSnNE4mH9qFewwnpy4kfL\\\\\\\\\\\\\\\/JStRYh+GTPYLVbUXITu8objbhle6zCCIb3ZvL21b0bcsKnvaIbuo7EgZzhyks87o\\\\\\\\\\\\\\\/EaCR1RvknUZNdl19JO4q59CIkRg7w+7znNWZnxe3+oOcd9x6K9Dk81MHsMeYRRCEy6JdK7NagKyLkZbB3WjhNInyD37yDVi4fJvxLp3g2ZFz+sn4ncbEy52uPcGw6+BEeg2w7ldbgIPvsI0+aUoxvUUCFSOmA\\\\\\\\\\\\\\\/e4j+OrP9jCBQrFjotGHVlGaAKmgEg8vVjmOUV2hHo2vLxbruBF4zafb7mPeg4mw3Fb8FgSbh+QUGXz5oaIlpyXwThd5d5yMwt1qF47ubHfXpvKPU\\\\\\\\\\\\\\\/sFoW15mBjjrc5wP0QD0kVqIrKbZ8r89vaOIadeUKuuc4JPiRkVl2CO38eQysrYH1d3\\\\\\\\\\\\\\\/Q+HmWRmyxWNpXmr6FmycPmj8RHQH3HKrh2D4vVeGB4dsCP7nSMTCuAzpnJqkQ5KkukPZe0GiOeWI1k5AV7Tg5ih6X2VvlU2bmr+vwkiFoMGoMMFSmYc5zr+p3tmsepO80Lk1YwxM6Scxl4QIaM1Z5PyaTSZlKdEXUb0BPbQumW4bV0XH6j06fi869XpuBUYk3p0J4oIQHmI=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00229MqQc\\\\\\\\\\\\\\\/MrjKK5ZvtYkAt5Ag==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022453382b5f442396f9cec14244c3beea9d69097c7d683921ebedbf2f4ee75d9f7\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/3.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/3.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-017-0312-8\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-017-0312-8\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-017-0312-8\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}