{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022NFCovtwZdJaO7bfKWIWfKyqAdk5N7Vj0A2D3nMOxhkXtW4TRQbF68JIuR4jDwEc63X+5rwqVfCYBrgom+52Jwzn0fPkiz6kqgRiUqs90KCeddeJfJWIdkoeDOuVWnMsAmckaKznP68jrnSgr6jAsyIMXwTSygF\\\\\\\\\\\\\\\/siuJuKLJoTcDy0+Cw0Hnu25Fs4PwZRtriGXb2yxO9A8qLYp4nonCWFyy0HOsADqiWBm3mZyGAsl4jNAIt+r9DtQJZDCgq+yNkGhILPNaBclbRFhTexcn5RoOQ6KMhNIZ+IygkHXeuHBVrVhRIwkiMvBDaCyTAECfP6o6lAPZKBIpGhthKk\\\\\\\\\\\\\\\/2Gnd557jxk\\\\\\\\\\\\\\\/xTd874gNhjtRjqhMNc5ipsr58+ADTSECKxPsDASRs\\\\\\\\\\\\\\\/Tq62Al10Zca2G8gGesyR3MBJ4ZIoztkpTcUm0Utze18XxFF90apClfYQ+Lecu2aXlcuTnR4KofXiOKHwkYcngTk62biKf3ctCwcAiHSXYXct+bqklPTTqsibqCMnvFmZY32nYfhOGG2LOE+ka0R6qT3TZPzdG1BlPIf+Rd06veb+FdbjiF32gqCF5rMJwuDyRnaQTHEl48aeaSzFGkKMQP8T9a1+UKBLsE+VCLhhkfMiZJtoqf1N7wHHgEkq\\\\\\\\\\\\\\\/XiS+\\\\\\\\\\\\\\\/Xe6tN6YQ0vXIjlrNd5bgOCItsI8rOcJ2xpX7meHJ3Z13ZLJ0rwV\\\\\\\\\\\\\\\/dKVgRmeh9IgNnzOE152MVuQFMmnfnXKLh+\\\\\\\\\\\\\\\/HiNwux4oL0RW5fJrzbn9fspOAvToe1wd8\\\\\\\\\\\\\\\/OGPdE4pFO1aXI6GcUJaIGVYzTXfohsy940z2TaCEUFGU9SsbeT1cNDZFBgNDuOU6sM\\\\\\\\\\\\\\\/060ihta9MBW7R399WnGgGvMcT8kHnzNNyfHZlQGo0yKaapk3j6z3DBjC3OXDClYGGAThXmN6wHdPmTTtU31Dz3rO+6qP5\\\\\\\\\\\\\\\/kbROK7biwDcAiXg3QKO7yhDLRvb9m0RB62bZM7fEa16zzW6jiUpd0IlkuGkJ2WqV+nNOnQ7a\\\\\\\\\\\\\\\/WRZ7jE1WtwvrMhxDL0Bkx4locTD5Cr2DGcmyyExwB6GHfygxAsN3eOSauPu+ImlIefDvMZVUepj8ano9fCG93aqSk7yyC2r930KKR2osIIvnF8IFhU5qYyQZe2YlXv25ld\\\\\\\\\\\\\\\/NbjHLWCDnn7A8rZms7z3wqqJyWx77yFTAkIu+Q2YQyFDB5PqS\\\\\\\\\\\\\\\/SXzOq5gZdcB8kEq3v+xqjWwkqSHE082T5o2l01WmFl5YJup9uMhPjtJMXzTBIEysASphBLYEwINsnw2eqo4JUqy4TihTV3X3tSq2P0CEh3sEQZFdItzJCJQYCiZiTwUEJDW8MUNCj3aKlKDubKg\\\\\\\\\\\\\\\/raOkOCi\\\\\\\\\\\\\\\/fnfC8ZK2ANz0DPfnWBOB9iXuKZ26mdDdYEB0rImML26c5JWAhmgbZOUvEN8HsjG4sbZnTtn3RZmCLRhjJTwP6IKrXor8fJCvTu5ODucJ3KvpmE38QzaxH0+h2ABvrdb8fwC\\\\\\\\\\\\\\\/XllxLRdn8efSMJzE1UCx13+3ss04y+LYEYf1Juw3mfY3bX+qMLTWWyAO0MsEjB1P74yL0ZGS+wkIoLmK7ASKObLiCvaEt8+lDkSFfzE90OtvV0tXn9G\\\\\\\\\\\\\\\/bJ1IzBnCfoE6KNJUu7apdEj3tQdHyIQ3vqKpQJy69AIOirzFyyCoV2DTKi5I6hbfjq8o+SGrPKU1RC3u\\\\\\\\\\\\\\\/GLVjOSJ5rSYbr5Ejug9g\\\\\\\\\\\\\\\/FbchczqSGnkiBSWGqHdyY9ay5yH0hJydaMjJ1ZbssyX76ji7b2jO5V3OY81G8GSq9VBFcRCtkNI93CXElmzuY0z5e\\\\\\\\\\\\\\\/3H+r9LluxqQ2H19f+R6aKR8yBsjRaNbkn5w9J04i3DKsJtKBnqjELEmlytAhxSW0\\\\\\\\\\\\\\\/oEvNNMJjDPanjl6oqMNiUN1JmUYprhwgslRmYks9Ry2U5ThQR+mC6Ys4L6kwNbMdIPYEbcrtNg7ZN6mu8afSVElgXBqBzJtyq50lHaTyIVFJzGCpuo4JtbaQ2H06r5SL81DiJEgocndXmsj5sLmZOo0s+Ux3gtPsBAeTEJK04vYeDLH7UcbfupUqwhBX6RTuWYRfkQ85NhmOVzStX8aO+E\\\\\\\\\\\\\\\/nhJ6g1dr+74rt69Y9atPe3trhe6lWhPLDpiqHGsBxWJn8qpdu\\\\\\\\\\\\\\\/AMUJnwqi\\\\\\\\\\\\\\\/j0XS333CCOlfUIJPBcE7fsjzuqf7RJXkAKNeESftqyofMea38wGmPK3va6fuKN587sZ4FEplEBnFfW5DqWYILY6DSjbYdwq8Z3CrWhiFNcxgWvVu+7nPwxIrrjM1BaR9PL0ftoLwi7UMgamrt\\\\\\\\\\\\\\\/JbdV96L\\\\\\\\\\\\\\\/yP4MTVL0gfIZFz58SKaid7QJ73Y7MoVPdVXkm\\\\\\\\\\\\\\\/OniDSPMWxIIwvWcLRIaE+vv2ivCIKapU6i4U2LusOBS0U5IkJD33XRkUxJv1wZkSmNlrVBwufO3lflfPQbI7EB5GcaXWGD07gNToo21IW6a+sb54EvdFJZTllaAJraSXVX3GvWQ3DOLCB0MU9jr3MN64b3wuPBgxKOoG5kstI9MUHmSNtX66VFOspxcegDuUHJ31cED59tpCw0Pqn2fqv8m1A0NClRDYdTmuOdnVXtpMXb\\\\\\\\\\\\\\\/dylE+MqGdSf3TEgYKivHIYwEoC9W01LfdldJDEAvIoTDbX5aA1Yc=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022CgMkfj4CARdoe9Ve82XjIw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002224f16f4e3a1a5492300d71b14111dd585b3affeb201b3821b2bb19f04ec8987d\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/70.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/70.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0386-y\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0386-y\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0386-y\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}