{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022KZcj76vtKZE+8oDSww1wmQAIwxF\\\\\\\\\\\\\\\/uG0jDKYs2HjWTMoaLW\\\\\\\\\\\\\\\/2g8eotUaV0MhDWHe6jE38AwfR+Hhz6T6AdBPJ7cHJRaud7P6zrYJA4jYWUU+Tf\\\\\\\\\\\\\\\/5T\\\\\\\\\\\\\\\/Jxs6klMb09ynr5Y31fyCTs5tupI0SvPPNDRtaMNxBUHumlI7iTl1ccCnLmA4aRLd662m\\\\\\\\\\\\\\\/f10TykjCMM3PXkUdDGPOFu17uKRIcWr46EQZ9boycWyTGSvp5kXARhCW7+8+diRCMzRMrahcBgtrL85rGZF2G7IbXwDCcs2kWxv\\\\\\\\\\\\\\\/7REDhdUSumbEvJ8wjWf7AO6BmpgIej557NwYEfD+Giv\\\\\\\\\\\\\\\/QuJD+2HlI3qCBnVDFiAKkMakyVpGMeGWTAJF94A+knXEqT\\\\\\\\\\\\\\\/CtNSqWNsIbKHGJxcD1XovpR0hs9hrSd8a2WQQjNRLP7MyTQuGqlkgy61aFJK9DxuOzq+OPEs5lQDIR521hBAnU5lg0kHUgOrF6G53psLaBQ3r\\\\\\\\\\\\\\\/QQL4F9k7jFUly8vKh6S5oLXOQ94DRAmI2wy7ZchLKhIHVD7wyqWhn1ryHLdeORKHb9HzELZJ9\\\\\\\\\\\\\\\/huNJIk4Re611iYG2sTe\\\\\\\\\\\\\\\/SiT09DTd\\\\\\\\\\\\\\\/BXZPE7sSN8Tba+Y8q\\\\\\\\\\\\\\\/wCLMr92fH0usELZbbalQKcG5IUG3XYcSWnloJqGeDlr0D0uzwYHE38YKA50uw+4xVgedZRtUhY6RtMiB3dZ5IIg9ubgtUqiwRUsaB7vsKFabj0\\\\\\\\\\\\\\\/5SABgVK5cd0sBcrLjwKG3gu\\\\\\\\\\\\\\\/ZTBDwI8LS56xyuOgm11uYpzx6amxa05qq3\\\\\\\\\\\\\\\/DudTXjgqeaT3OFXZJrM1nyYfQnTZGDhEq8WAToYfHhqDSXynPrfFkcDqBE5QXtyO8grTmvCFzRiztFwea5YqsyFtJqTf6kBt9VLfQNvCLgPvcO17PYzxR368i5Cdp3Wr0mzqz78XPSls9OfJyIXFTV6hcRkAxE10tQ0BsZvDUmnYzgpcKWNsnALj7d7Os0NvVC9ABQob82C8Bv1X6dnyxI8cfZZTMDx9GTgZOju6ZlpBhKNOM36TXscSPbECIF68s3INMVfHSbkQV3f5TnPRZ1KyH8racCT50mW9cvrMcnkXbGsmFmPcPiW+76rjeXG7eqpc+0wxTNqlu2nbuUf3nonhGkYWohiZkyZEyI4atTxmI2xljDtvV+YRmtoriUQoGD+MSSFLt+DCf4IritFwBH1oeTq\\\\\\\\\\\\\\\/Leer8TBeK0PTllm85weRlHwgw7T2ex9JD7vvZxJMnpinuw9wseqABNzpTL\\\\\\\\\\\\\\\/j8nOsYpDpkfDYiuzTtpee5pcoBEUSeCvyvqpPckZyJVjwIC6wloBVh58i+G23wKpdPD00oSIOl5YViejFqm6v3mn5vqUHZWA0a9K7NkaZCc2DV+xNB6FOGrKDsqtAX8cC9NjrXDKoQy09USnRoFbkTR+1CX1yIS4I4z3UT5leDLURTUI89UmCjMuV2V+\\\\\\\\\\\\\\\/T2ekWGzbe7cn\\\\\\\\\\\\\\\/waeEYHlSe5DSS872k1YDXH4n7QJXlf7gS9IC8LaPa0xdCzt\\\\\\\\\\\\\\\/3iZjL7rFsTlBzpXDUvfs3lUpaSjjE6FFn\\\\\\\\\\\\\\\/ogfKHtTFx8aK3b9NN5R0bhOK00cDLAoiTZFy+lL2L8dCjZOoRQ7gA2Ltel8d35+iRFR6DNACGeN8O6DowQx+PxY9O6kTIMuTEUasfnkcc\\\\\\\\\\\\\\\/eYfKr6ybMp\\\\\\\\\\\\\\\/F0PbWU0WEtbH4Z35a9Uj9b3McCOQ9+uMObZA9h6DI7XMOHjc3jp2L5XShIuaiMfI61bbQHe2geViuqfYKVF8oyTyPZT8U2lWnFvcCLDu2J+itdGfaj4EIJgtdy\\\\\\\\\\\\\\\/+dts3lX5CCTrFEJWy\\\\\\\\\\\\\\\/eKZnDW\\\\\\\\\\\\\\\/XMkVNsNLZSaVKkupdxLvBPI76dUYeqq6tyI98CvjIzz22Zp3ojecbYvjkzHuuMN7Km6sUqlcbtnHQx3DBYfeF2bi+g1VlcQT+mnWLY1zRvyuZGqaPUNVzoZ9hUTqnKdMqXTcewTUVfxZRBq+mDeMfy3QH22tvR7wcIinyWevmVn+ixH6NJniiLq2bDH2EjhcaOFUYIjgGyp0QYa2D531Vfo5BqQKi5v8vfTKAeklC7ySI35wDNuWnYsNpcAGKBE7JURQFqon6P+qXFQ+BjKtUqmLWlw1cvbM20aRxHl6VXpdWPfzw1eQLCCSj0plTKRcPNUrt13WVXcjxBsT365HBCKH6vljkUbzf8XJSVlD\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/L8pTy9G7EDB3+j7xuIQesJzVVw7lm+vfljQuHbJq\\\\\\\\\\\\\\\/3poFrHkqoxmwmPW\\\\\\\\\\\\\\\/kSSgFWqzvwjrw2tUdl+vkGQ7zuMqByFaGi4Pj3XfMBJVLHwbv6yyr6Q8qhWyp5wtH4CfsNFamGGnrkBpTHJVwg\\\\\\\\\\\\\\\/Vfs5UImbQp7gaGK\\\\\\\\\\\\\\\/0jNsaJVx8CNSRY\\\\\\\\\\\\\\\/nG38SZbZbOescKQNb4P0+AJxVRA8zDklJ0UEVitv3FrGzyD4HUhT7wG33U6130dNOMQzZeWWiM88AfPamWNRGBRckT7TN2D2EiAgXeUvH0Jy\\\\\\\\\\\\\\\/BAwb3HQ\\\\\\\\\\\\\\\/UCc\\\\\\\\\\\\\\\/9ne4rzvGSyvcHhyJDGICnPgodgtkMO6iJMT4b0PDI1W161+UCytJec05\\\\\\\\\\\\\\\/EV4hFWH9YS95o\\\\\\\\\\\\\\\/gjkbDfA6J\\\\\\\\\\\\\\\/lMUrbOPSmdOC674jO+FLraU1nYEZ6POWPfGlikrL0mHchymFkpoO06Q3zpp\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/KJZvU2Ocs=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022fRRPqRpVOlysDYG\\\\\\\\\\\\\\\/PElknQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00227f10018aaeebdb34214461008b964a4adb84009089ef66fd78590b449932e3e9\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/6\\\/1\\\/61.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/6\\\/1\\\/61.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0351-9\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0351-9\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0351-9\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}