{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022xq3TilATTIfDAVQsC2iQHRxl9kqrJcDh24OIflLPuwOn3XOqdKUlKQgd+UQ82ZV5QUELZPZ8ihIu5Q7aW\\\\\\\\\\\\\\\/vmQv4+iicIsIFOmpRdz3khTVcb8nQ4TI4w8iF0kdYrHF3AmXaB8SdhHNpuCIAXioOmhY5JdiQtGiAakRtMmYe7noDnaudZKZ9gWHz3+rtsCjNBvVh5ysjL1ywhYPtXnTrSZEM6z+HJCLyWFUgir+8kkpdoPVAsTGiekTYF8eQoz\\\\\\\\\\\\\\\/2VaR0CRX3XjlY2MxS9D0vqg8qS0ZO9V\\\\\\\\\\\\\\\/gsTHNXU9nrxTeiIXvfN\\\\\\\\\\\\\\\/7sefjj0WCuHy1npPTz9abg6PXgPiTMU81H4xE\\\\\\\\\\\\\\\/8zuDOusNA4sXEdVvyOo+vTXOqBM+ArF4bgcHE0mLLfC7a+mKAockPucyHAE3Cex+fYOVftYcqNVzjxeJ9kvT\\\\\\\\\\\\\\\/ulIRTdNGNZhEn9ZtPhmkSOTZyPXXYCTIhdISoSeMAGdh+qp+bEGGNTDVrNVeGKggHEtTM3wV2YxyIaZ0DrRKtksAZm1lV766K\\\\\\\\\\\\\\\/TwXPIbC\\\\\\\\\\\\\\\/BldCRLobdLG0GrUJO6zrRbSydKvS0B6yRwvvtQlpYg9Wifw7q6ZnfdQdG7aAzbXn08Aud4FjifQ7A3Jo7eCvAes7xVaqp\\\\\\\\\\\\\\\/eKt8WUPubQ1SnTLoGiyYXtFxoBpVy\\\\\\\\\\\\\\\/LdP6g3xs4EoiCYdENlOwuyYRRQjkHzHWhcsAoGRUGtYAGxHRqrPHYVk\\\\\\\\\\\\\\\/UjYXBKHFYXBy6VlHgpruWheqcCgv2aWl9eY33v6LVXBbOL2fYdfrvv26+Ml41vQQqfp6DVWMY6GrHJ3KeQcMsbiA08CndN7SrAJbPN0dr9q\\\\\\\\\\\\\\\/oTe3zTnDQ+X8426PmzPGd8o+zM0kSYTm00GAYIq6z+YeHxweyxqktAwWIYFf1Tg1k4F8fG8HjjRA8Kp\\\\\\\\\\\\\\\/PzUA1AIcEEopaa70vRvsjcNxAoRAXsX4\\\\\\\\\\\\\\\/JNY70Tx7Ybt7eWKfk76RNuqzsqT\\\\\\\\\\\\\\\/7MOcXdvT0\\\\\\\\\\\\\\\/9qJNxgSsZ9aRCMj+BWTOshi\\\\\\\\\\\\\\\/s6uZotUknlw0838sfAmpodK6MMe3ZrAObP9Ms6gdFPnOuy9ro0zQwGKl4IpIkyeqaK1K8\\\\\\\\\\\\\\\/1VuE4sAPvKXk1\\\\\\\\\\\\\\\/fftgKhZrKM\\\\\\\\\\\\\\\/GA9qDlmJrotn2jpr+gWSwcxsrZ+GYfJd4RH3j+GT1oz3P8g5riC\\\\\\\\\\\\\\\/4upx\\\\\\\\\\\\\\\/vNJj9zshUaSpp2l8PRVlfXqP1mpa5\\\\\\\\\\\\\\\/p1cqsweP\\\\\\\\\\\\\\\/uOQJcDHIc3qqCs8xs363NsVtHOOLg613JaHDmVM+c8p3j42ob6JzgWfhrTCR7LVkZwa5siZXdfN0By5IPkHZl1MkOG0FhdK4F6W\\\\\\\\\\\\\\\/EWAvrNe5FWVgylyqM31LNHZHfs6KlCCOpViKy4clsgp7she6TQvnDFa1s8Ri4jvI1ZYrHZGeV8NH9SHiPTyA3MOLxT7ro084eiJpZmOBPsspzjOm4gqWD2OMUVwiMi1Kuz9sNvU5wVqeVGw23n+3Eu4lrjp7laKz3x1WLl0sRqefJTc8PsM0KIln1METx5Lk\\\\\\\\\\\\\\\/oHlqYjbVYDBxnTODdV\\\\\\\\\\\\\\\/8+zwSLpdlhFJB5o37Pt4OI3eiIm5uCiu\\\\\\\\\\\\\\\/Dmeb9Yz9vvBFbefe9+1pOiBSu3+yp8sQDCm9RxjPZyAvp+C8Vu2Hazs+\\\\\\\\\\\\\\\/b2Nrf4n\\\\\\\\\\\\\\\/wckjUOF6M+3BMjPW\\\\\\\\\\\\\\\/Iy4JcxlicQSPckAHxBnAZjDPmanUwMoWAumorXUNTlzsD4XvjOsFUX1w35YXpJWt+OR4VJKBd8DG+WUtJZUsg+w\\\\\\\\\\\\\\\/Keue9zkUMXzF15qAOnmiD1QRu06NA+795t0PPClJmUfREKvBzQtYWCU80MifGxipxIc8oXkK\\\\\\\\\\\\\\\/FoUAMDTDn7K3TrEKqzVslgsWi8dWJYNqyi5KcPPipx+QFIuYQaOJi3OG+8LPsDleJ6nW4F\\\\\\\\\\\\\\\/q9owv9ANtT8AX1DfJrvjufH06nPIenj4v9sU04j+kt1TxoI8tz9f3nMHtTAPC2SKljl3v7HoESXFxe07qDIleGBE3r1mbhwVOp3scJ6BalCZ5puFpsUj9bUaBQhfEUZbEgfcnhpmvoO6K4gGJYpTxK4fNgoCL6B4ypMGhu3wkjPXx9NFONkYqv+NGSy\\\\\\\\\\\\\\\/WQ1+4PzLhi2RGHCLVYRga65MS5cCLLPlyPpuq1zYyt70hdt6NWY4TUnIjJF+HswUTCxjbjY8XmGXBUG9aNhcYBT7Pz202pyG+QHFiMWyi8tLITvgWfo3hr74xUO+861E0e8R\\\\\\\\\\\\\\\/8YRDKAUOKo6lvLd83R2y821TzmQKNHdcFlk9M6VI+M2nUW7O0B0Ta\\\\\\\\\\\\\\\/8mr0bpHOlE9BN\\\\\\\\\\\\\\\/qoJSrVihb4h04awxXon3B45upxzshK0NYVG\\\\\\\\\\\\\\\/gL0i5+fViofqcPU2JP2yt\\\\\\\\\\\\\\\/zsGfngr6nnqYYXZ9zDZoLdBWlsqfauB5OzjkO2AGWjYeErd\\\\\\\\\\\\\\\/bbqHvN7e5zVRE6h+CcJXoFnbQi9LS\\\\\\\\\\\\\\\/O35QkI2bV\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/BHv1autcIwFp3M3G3v50cM4LN5ulvdB382N8CDEhHRwVHAzvEOZtnsruSSSfrVktR1yWeKOYYFveV+Wir9FacPnBP906pqtCEuvyWLjvp3o9m6mBP5jSQvpiQXziv8+ORG3REtABKcnvW7QpJ0aJ60d3JacdTpcpDluNuS4SQpRN4s0PKBGsSWQLJrGrl7oqg2lulPw\\\\\\\\\\\\\\\/CT48Ov4LwOu\\\\\\\\\\\\\\\/Olg5Ryg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022Xd9iWEVPZSilz9\\\\\\\\\\\\\\\/gub7KQw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002236b10d4ceff2a8d8a2eb9235d9e3bba69607010f3f7e6f55687a652af5f09f9a\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/5\\\/1\\\/65.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/5\\\/1\\\/65.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-017-0269-7\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-017-0269-7\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-017-0269-7\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}