{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022aha6DyxijT8tXYKHPn+SskamWjvq3rROUjlI6hY3Lh1LLRBED0uRrqFewvTLS+6IxJJSyklOmCk6yStgazCPk\\\\\\\\\\\\\\\/MLvPOkfrys5U4GKZ4ZeQlsfXUbq21J5tCARgcd5KigcYvPzC0oohv\\\\\\\\\\\\\\\/EA6N3sWfLxcm5VPK7vHjdDrrqjMAuqOKBWK9qDrK9V6kRD0o\\\\\\\\\\\\\\\/CEvGoMdiK1w0Wmrljf0aXphBPmRflaGDv4h6\\\\\\\\\\\\\\\/CJaOGwtqsOhLg4Jt5AQPuWLBGmkXxQNiqAqU6zmEadEf4I75FGKhDb43zzZKX4soe434BwJZcfLn5CLGffcFaCosKSrMwrPQW6Zy4fkfD2Xcq6yGBQTdAjs6RiCsA1oMPP+sgAUbe8wXaJA\\\\\\\\\\\\\\\/8wWgPo7jTkEjpGUWb2TnaAeLn3lIGz3hEwXeCrMr2QzGW2Jp1x9JL\\\\\\\\\\\\\\\/aDhUIYfGORCM2SUlqXW3NcjV\\\\\\\\\\\\\\\/GHAHoZZ1J13EBemx6gjbpp6lPnHAhHXTQsiW5M5nXGQqAmp9ourFVHVndxNWkRexjWIjn3D2x69fuD4NVfrjfBGYbWJ1xNnOA51jtyvf1l4C\\\\\\\\\\\\\\\/VW6+k4e5ayhGxCFIUImFfsPyKw8Lc2Mo42VTRZWohXCw03osG221nohIdCYqPnkyJ6ioRKsUAdmah2KxljHnJ1t9m+jor7nJF9yvyaAF0R4sFmhuhX91l84RVPj3YaOSoRCsOUVTsREltM7kvNfpJ3bXMiPq43Io5Lylu2uQcT\\\\\\\\\\\\\\\/dK\\\\\\\\\\\\\\\/ee\\\\\\\\\\\\\\\/ouUHrTAsbsQNyE9vqRUaMX8PZfj\\\\\\\\\\\\\\\/0+D++fpHM8x1q3TiXQYzS9XMlwWptiypV\\\\\\\\\\\\\\\/OmhnOy6gNv4+PBz+xs4MFe3YuxVfvR3gj1A3Y6BObuY9I5ajEFnA5KD4iM2tPVBGWePBuWvml\\\\\\\\\\\\\\\/B5+RZLFcaYyeRzTK1wVI0n5PY0YYXH6158HMs8eUQkpqPxLNQafaR+lS9FcPVifOjh2v4cTmguHgbh+4fIPHrZwv5z0jYs8W\\\\\\\\\\\\\\\/av8qVb5g3wyI5uk+RGrR9mS8wIqH20j7Kcup\\\\\\\\\\\\\\\/pXnEwHDPUWgA2132nX3BtGY5dpT94FeUmSP0hGGrZW6P2bkq0\\\\\\\\\\\\\\\/AJeDuHrInZMrv0bY2LenvB8\\\\\\\\\\\\\\\/whSEn8ZGpeWEv60hBWhAbdYxurDXoinoA9BM9VTh9acDu\\\\\\\\\\\\\\\/+5O2AatLmDh8wwX6FY3mLV6Zf4Mxtx1pU2Yjin3xlJ0gqetyUpudtOczGE56n+0no+kb6lce2UVkvDsm9YH1OF\\\\\\\\\\\\\\\/qKDW4mc2n3F8ZP4TACKW+1shu9pUzDdP2Wb3Wbqdbd7tfyQYKy+Hh8yjTYBhW+x0\\\\\\\\\\\\\\\/4KY49CpMV312a3gAh37iZ2FUv7goqtNQz9KaxdTzJadZPiLJ1YiWZyzbmI2jrjWZ8GfzuN7JTj3DXomws8s76oOnr65o4LgnWJ9xR9umVSB\\\\\\\\\\\\\\\/Smns0sK8ol\\\\\\\\\\\\\\\/SzEVuCXcExsoWOzSKR4\\\\\\\\\\\\\\\/ZK9kPsfPbwIh3A6CKmC3E1k8zkG5JEytsG6k1BPMYDU0fAA\\\\\\\\\\\\\\\/YtmuIZZp2d6\\\\\\\\\\\\\\\/2a\\\\\\\\\\\\\\\/Lp0AnAZQqR\\\\\\\\\\\\\\\/VS0iLKiBnpva\\\\\\\\\\\\\\\/6m1fRx5EJ4+eGTEg2pDYtnW2zkroDWNx5tFNguwVcYrr3Nn9Gq01f3QNN3\\\\\\\\\\\\\\\/ot1JaOTfW6GJ5x8cCLFw1HD3G0CU7cZkYmgsZ5Wmot5BSiGOcjNMmwCZJ4Intyuwr7E2pS6zYZxyCYB+rDoBEj7hQlZQ8kgMAstzqMoOzyQ283ECkrekKatdU57aCx0OzzqlYB0mMM\\\\\\\\\\\\\\\/R+P+prJMJNTnANUXvBVfpcrrJKoIUABm9ydG3+wkVIN+4oq2x0Dln411KjGWKw3n11KzeLhLQimiEypHlU\\\\\\\\\\\\\\\/wQRSt7\\\\\\\\\\\\\\\/6NBlQGpF1SBFfDsnohYZKqV+iOmb+LMS43KN4XN97Ty1QMBSPmXqzBpxEMdOV7hMgqekzNgLMzY\\\\\\\\\\\\\\\/aiISRLNrNXHPR8ULePKeVTrMHJjIi5EvbePDEwkhgHPdw5nQrW4knIRmiHge3s1WZZHjE+prl1xAJN1mnVCZCKlUUe+RUY5DQK27BgKVsk1m3BxTKAX2YRU8BJRAz+yDR6Qe6Kq7aCaFdMeLSBM1rjZUKMxoV2TJiD1PblDEzgQX1mSK8\\\\\\\\\\\\\\\/L2gSTeAD4bNtZh7iDBhHbu3DzVkfcC8Nz7AdAzve9xILUYsFmLz1JsyT8pXd7Q3gng6rEPyPhS+AZaUq05p7KHz4R2rHCzpjrT3VHTruPAtIzp\\\\\\\\\\\\\\\/W39KD6Qotn\\\\\\\\\\\\\\\/NTIigXXUL+aXSOWz9zkgvK6XjPdHV5QAJKTF0rm2w+Iqb4hrPSkrs9QZ6EJbo4cfcaPE3XZ170RvrNhEd7ZlQZZ2Mtu8nVBgbqTG\\\\\\\\\\\\\\\/ot6yDbPPDbiCmRxB3mVjRraA1bzzfppgflyskUUZKjCXva1wY77\\\\\\\\\\\\\\\/dJFnZZ576L4eT3Wt2GFHRVWTJLv5LXb0avlr1Fuz3krEiMCqo8hUt1OCYZWe66nG6SKp4NGmys5BPl9vqf\\\\\\\\\\\\\\\/cYYZzXdeBMWxuYYYa14coc1VJLl2wPRIUNos9aF28WoDHRSyUyD1vB3ssyma4L4aiJLAKiq5SOj3Cdyau3JcGie8s9\\\\\\\\\\\\\\\/4kS5nhnWcrvlQOVsyG6Wy83KywVYNCeIg61DJAxbZXblbc28LeksetMEJ8KlNawa2N3ANfTcdwXWLib\\\\\\\\\\\\\\\/TJqVDQ3j4kMMhEtQxvz0Eek0Gc\\\\\\\\\\\\\\\/rM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00221OVaFn4nO0\\\\\\\\\\\\\\\/PAtjY+fXePw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00222ccc6aaaeb2e38945b05da18808140191d46d3354e9a416207b6b7492069dd28\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/8\\\/e007854.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/8\\\/e007854.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-007854\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-007854\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-007854\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}