{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Sv1PoMskopngSlE6pBssWSInvtPEEN6qvAwElQlqpAn7BrAqhm587pwGBurTcifomUVTIBi0iht0pVQZyzIeLVlOVbyHuoUwKNuF\\\\\\\\\\\\\\\/PAiO6iL2hrssHU25dng8Kj5aBrzGbm4vwVlwp4G\\\\\\\\\\\\\\\/RlpmbzU0a9BwvRPRDXv0Qz9zITD0lj\\\\\\\\\\\\\\\/JtLb0nOecPfec0raYbD055sviduCc+LMRbyp9078trivcKBIQh7DOBoUXjJiZ1f8o3rLy7GvGonJU1f+wJVnI8kqtmXzcHa9xp\\\\\\\\\\\\\\\/bp84qwtnwsnlipUal7L01Qt9xXvLgJYQXH4NUIIf6iA\\\\\\\\\\\\\\\/1OWhuHqKm3tLHfh2aYATkTHNmDT5DeRxkkaT7A5ergg0y0nP3DxuI8MTURO6M1N5Vy\\\\\\\\\\\\\\\/PqJFBG0v5NudsbBam14aCjbAtqOUGZGoX51CQQosuqmwxkQbfZE41vxP+GeXv+0ZzmxBn13GcqbUlKL3UwL4ZQiPlrS0xPjaPpYYkxrFMFREzuPbzheFFkzBxOJGPn266d2EiiqtT\\\\\\\\\\\\\\\/medhX6KGfaf4jS6fziwULZeuLRgEPog6h1hGeW2GGbiYb705VeBaVA5bjcPd+zxu71XOALsmevu+0QeaaOh4XtN+j2Hp7JF4G\\\\\\\\\\\\\\\/4xk6jrtxRLYbKHCwI\\\\\\\\\\\\\\\/MwGBXiOB8tA4tQYJLxntmCeemfvE31C0jvFE4xSnbGV2gprRDGUYUPfcDo6B6dIiQykaNJ5F\\\\\\\\\\\\\\\/V3X0kMsXF1h\\\\\\\\\\\\\\\/D8x5rP7aO6ytO7YOQyD2coda459yOTNg6JcK70uwgrJnKqUSbPIMeogF7cu1D0Km8XT686hy5OBCia3l2XPtAQmx1nkfK7kQyGv\\\\\\\\\\\\\\\/Y7MRjhhiM78YFyep9nYGlvAQfZ8n\\\\\\\\\\\\\\\/yfc3Pgjo\\\\\\\\\\\\\\\/0omdjG4sKbFKXmfZoFuN83J56rnXDWl7L19aRI6WZRaT2fgZ0RhLx8oSiejrexiZ6QrVx4avfbly9tcBp1TvUMLm+C7Tb+meTovGRmrB+VqPSVql0TRKYrCrJH9HmBzQ+vwzgdSjhisPojnU\\\\\\\\\\\\\\\/W5deoFVERa0eSq5SYdkyhszAIJq4aSlk0JAE5z48sQjNV9yuH4XK5kbf89OTicwK24NRBwY5LvYGkJGu+2grDlUZrhW\\\\\\\\\\\\\\\/nDsStibAtVGE8\\\\\\\\\\\\\\\/qtXAxRGKoCs2qCSBh0loSjrFHuGpr\\\\\\\\\\\\\\\/ChkL3VKdltOaDeERXPMM\\\\\\\\\\\\\\\/mW1oZd5xV+QpQI1iiCRmC14fefU51zCHVSgpgu8xn7IS55xyvvai6h71CkbRSC3uEP3MOOAEzoFpt3ssszvpweDTcPHUOBrlQKf49hF6SY2FeAa6Hgvu6Flavji\\\\\\\\\\\\\\\/7p8ZXyPuGn9lA5ZUSAMXMaDRvgGgiCUx6TM94\\\\\\\\\\\\\\\/8joh3nCv3kK6M9wW7TsusgnY\\\\\\\\\\\\\\\/5v5fX0Kqj9ejI\\\\\\\\\\\\\\\/PznoWqr2hguSdUF4vIOfs1hcQ3tqbYvX6oeUWnFgcBsE7kWQ7a7z9AdOIbtDk+d\\\\\\\\\\\\\\\/vCzE3K8MOAifTxIn2pXtXS+\\\\\\\\\\\\\\\/pnpkFD09QVF\\\\\\\\\\\\\\\/J3Su7p6Js7IwbSp8pPQ0fOE55dC83ockrdwLNroJhGoyYqdMIUJg2GQr2uNxYgdzJH+azFb9AFp5cKjuynIrVT2XTFuPRxon00AYFQpAsHX8C5jg9TYU1Mp4nnWd4kk+MPEhJXp3AfccxmW6RWxmz5gucQ9gH\\\\\\\\\\\\\\\/giWYJnCp55zKAJxoPwzrkG4qv2PpEqASviXFvJ8mPHx0cWsl7Rv+JDDASm5ltfzxzC\\\\\\\\\\\\\\\/uYsY\\\\\\\\\\\\\\\/GqPx2yDTMApvx8Z+9MC\\\\\\\\\\\\\\\/FxZQ6vq\\\\\\\\\\\\\\\/jErwr2o3r3\\\\\\\\\\\\\\\/iTBb7q9m6su4V+Z3r\\\\\\\\\\\\\\\/8dhBqGZRpQE38tuJ7w9T2l12yz5BDGdsfbSWlh0dDwOSusZNIn0QB8uh9YhfvNipYsrqpEUiPks6XS0dPPH2Hfo05lmIUBV\\\\\\\\\\\\\\\/jcbQbVqfsSQiWJhVLq9HHFlIJy8rOqhVAYVlLqJD4VGRJGTeMtIueWIlOOQVft8Gt0jIQ1fC1PNAIwO9nEvlcOgeJ\\\\\\\\\\\\\\\/DKAc3Ewf5TN+oA0PZ7jEoWm3xvCXbj09FzaeW26kZTe2XNa5+znHQ41xLf0pm5HjyZL8+ETKQggIUOAGeDh2iZKfulpMVHCK+k5zj5vRdJrdzlFC5RpxjvAPSvxuIOuVdignaNB2SnZm0jLsDvL8dtqcBXEsTWcW62R4QyIFBPa+bTTcbpmLZ48ThAx7Cx4Y2H7uTN0MYmmNoO6LI2PQYkt9HMzV37M9JAS7WH8wRNrAduJW0at0T2h9L6GqL1JG8+JRH0x+pdkpcghYsjxvXVIJNiNSZdcWcXCqOWjQfKpOKvDerB4jRf+AmncLM7CoVlZXiO+7TTABq+LMIV1uNnLYaTKyrFspEHMmRZu0Gtj\\\\\\\\\\\\\\\/lLWErOeJ9j2sBDL9wgwi1f24PRbxKNwbSg6yzyjoj4lblAHij8e89e3zgvQ0ylO2MfVrd\\\\\\\\\\\\\\\/ET5U7cosElRIlSk5QmPSnVSbCrPXTrIt21XursCtDVoXt7asCxbLVG14yigyJ\\\\\\\\\\\\\\\/dzxPgjKqGsv73VF8LX1fwEFVmegLTRUoKeg9mj860XkAUsfMkwkW0HCYtyGH0rAhyoG3ix8YulMwf6XNIl32jShStjweE5O7etaDYjZoIMNysYGgsaVOJdB0vaoYVb7mKEi+fRw9TGnNz89SaWtexBfnaVsT0sWJ5xPapdcyi2Sc=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022uhpzjz30KE+x1PZbE21AMA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022e70355658a209f5a9ae4588434629e3fa89f4810cd8d972276cb94d2cd62baf5\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/5\\\/1\\\/92.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/5\\\/1\\\/92.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-017-0295-5\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-017-0295-5\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-017-0295-5\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}