{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00227nA8SlupYDgeS9dxZGmx06Q4FKWdVo\\\\\\\\\\\\\\\/RG0yEaGmRDN+hqimqTCpexy4aiGBs+3CKfsKb1dGs5oeg3yxjPXNt55zwUwE3h54CG8ADMsR\\\\\\\\\\\\\\\/XdWRo\\\\\\\\\\\\\\\/Kl\\\\\\\\\\\\\\\/cqxkExLu4lGEIUwQ\\\\\\\\\\\\\\\/xneySKy0e7IALkgi6yX8rmW9OQ6ZHbvxnPfCcafWDWAdejcC3lDStysx9n2xuihxtX3T1DSaIttt0YXZLS6Ed\\\\\\\\\\\\\\\/VIKhOhgdqxdO8LhJlJm559q29S1sLulAbYPPLF9HiIAI5PioHiApQIvFtQZaC+VTE35sFfaPyrLo59NuNvE+pmtkvE0Hav7bjBKjr9+FMbakpwCaIqFWLgKE19EyJcRQnP44MNo0X9iVi4NiRMHhgdir3ohwpAZBVj3cu+pmhSWUhMIhDfSVgGQ8AaBYnh4CuKRISCtGO41KPcpKfEED7DccceshUPWmV0O2chc6IdgKQchYMeTuL2R15P1frXtPyJW3HpLnFALcIvq8RSHtXZTieOQRU0yH8be13aQkcu5LR9JtVbTiv5FWpq+oKmIHRYtKAcw7s+wub9Zi8zYtfPtfglj2G3hqI8f8VbTrVvlhX+n668PVsMJcNd2PEer743JqZ35KWGbSMujKCqLik+PuTGJwKpWAhPsynDd4Xk0Z6Cxk82J5sK+b1a3DDkuYNIiwe8tcmz6w7GJlLUqZfMJ5E0aj6gj2\\\\\\\\\\\\\\\/Ex2JO1xbFPd5eVBnmpZcI9\\\\\\\\\\\\\\\/3VyEwtok1tNbqUoLAX1q5XNlOoKytOUAuPvnh103Lv3ljuXfb3DuBRcSomlegYI55yBJ5E6YkOtNcZV2MlFzyWCT1d\\\\\\\\\\\\\\\/YzJ6xgb6y2m3v7G+8iKvdzWKZV\\\\\\\\\\\\\\\/GD4umjSatSi9TPzF1L3Pmjuq\\\\\\\\\\\\\\\/sxLdT9e7TSBAOs4inms4WIzOOut6KRAjo0nOJv7gP9EM+G9R+vTrKTPTsMjduBtYJgirywo+JJmBeIyzZjNBcrxkofUrhHFJjMDb6IegERXh65pglttSUb+87y\\\\\\\\\\\\\\\/HUK4lrW+A663UR0VMqUmz9+Dz5jeJXDKRux7Is0PdBI\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/iQrX5D+gIxQ70ggG88xtuGadC6uJSIxyA6H1LBzVu1a0p3sUUauNi4ZWfKrl73TN2XMl7IHpz15Oi3GnUggED13COKQLLXjmrakUIEP2d6pKS5T1pn4daLPPoWFzpvfR2bgQP3fg7Oxg+qZQI\\\\\\\\\\\\\\\/UdHKPMrJtZQVKNBAGIWPDbqUxUtqIgXuyCpaZShvCdCggTDsQrWvXbQkXq2x0U9pais+W5sKBjMJExcgNpoDmybEdkAGCg4bjZLej6VXu4SKRfcss14B4cgCAyQ76cJaayn0Ezqc52Ia7tqYs8ZYAMtu2lme8mUn3SgFwUbrQonUjOpHf+hjvJBya\\\\\\\\\\\\\\\/dSHRVh9hWLEmw718\\\\\\\\\\\\\\\/dr6fBIaPFGjC3vtGFyb19gYI7tfZr82tNS4Py1xUMuO2Z2mafyMOB8qY9QVO3APLnPEv\\\\\\\\\\\\\\\/hkv5kzs2khyUEMbT058y4BK6Xb\\\\\\\\\\\\\\\/K7BoQL38BLV103EcA+K0aPk0bYqAeVfB+FXlg8aDHELrkoW7leteZUHrxgzPqQpWNrF03qSBBXYkjSstgP09IdtwrauGTPL04IbW3\\\\\\\\\\\\\\\/z66kNzhhBRSsUu+FXADWWNA\\\\\\\\\\\\\\\/Q9BREuwYcXABqSRQ6MZmUbmJioj2GKeyBwDAMX7+T+1epYkSYoY\\\\\\\\\\\\\\\/qK\\\\\\\\\\\\\\\/0NQpAMcxLBJM67JECY8zLelAL9BkJmWCALZL7VTAbxhMgwpBJ21ruSfbNBrFzIo6mxeDCGGBTiT3uPhzRvjd5bWVUPS8ipiJyR7vbACQdEuAt0E0dbSJv9tRZHrmW5laUvN3Rmc5wcUEhJxCP9KWLMcCqw4ynKnX+4yL123feeke56iHNv9yws9qk0aDmKJkMD6mB8h04PPTl\\\\\\\\\\\\\\\/ryTk1Zzl4egZkrBHQDcfyYzsMkuFJCsH0PNi\\\\\\\\\\\\\\\/yry6pD1gGrciUZ3rNZQ0Xt6QHg4lObW1c0Um3JtU8Yv0Xj3ni44VELVxNrJRN+B51\\\\\\\\\\\\\\\/d1XBheGqqpb\\\\\\\\\\\\\\\/DFPBU1wpTEFIhsD14A5MHySnOtqqeyo7HTwi0QNgI+QF2IO0XJkiiLlBp+Ceqwo3GYFwxxffAfRtvaE0kIROtJuXK2JS4fl3LyBaWC\\\\\\\\\\\\\\\/zVFzytfz9S4ei0AczTg5Q7pdA13DYQ9bAgAURTT7C+zLF1dpKygB91z0HeDlb4W17Gjiaudrf6RKn65mXe6bYSDUzkRLvVtt6LCudtp2h118P3V3zQCKBYAT2jGmR9XQJyJrT8ZJso0YFR1uzJuCHwmK1Q3ovWxXOn0zNL9fToEGex5J1ZOM+kAm+vKmSIxOWdN4wDQO0C5jeqTWaQU2XLUbpP655wXfL8HmoOOuBujdnourLnMg058G9xdjMyyOj1OTb\\\\\\\\\\\\\\\/V32Nh3dtGqlPdK8jBYmNQ7hpVIFejceOTtc0yj6AesEWLCkJ0w5DPBljxXqjt1zw3E8+GFQTMKzDlF68nMAh6D30pA7CtAvVeNVa\\\\\\\\\\\\\\\/mGHUHDQ\\\\\\\\\\\\\\\/37SM8JD8KVCZ7D+oWiziwW61vnSSNuCJ5tP38G6WTcQEzmoj+mMqK7EL+lAqR+cRl1nVRzk4PEiRDQa6bfI02qQRo8ub1qRCyWk0fWyVMPpaNgKaBgCMRjMyYrAaPY996vru7Xs5t6cdD8tROQv3dRY=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022X8FKMThF1w5095SCMBMPjw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00221d1f82ca9798a12950968a86b3202be1374e4a2a5425ee439faf7fe633cbd4b0\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/5\\\/1\\\/101.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/5\\\/1\\\/101.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-017-0308-4\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-017-0308-4\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-017-0308-4\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}