{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022qC42kNVY+WClF+izjQapDBRS\\\\\\\\\\\\\\\/yqwKR7xQOUluijnU8g+SkdXJNNKQjZrHG981sgrLnSltK7+wX2zoCCErG+IZg7NyMktAz3HWnUVF6tIDQ2saX5AEFnbSLxm2P4SWW+VhjndTC\\\\\\\\\\\\\\\/uMJYbxDpbIm9GcRwk\\\\\\\\\\\\\\\/QKuj2XRB\\\\\\\\\\\\\\\/nIcxnojoFJu3iPaPRlkdEpmRLZz5eJYoH413QPDKSno0AvlhRO9bHBxLTqy1wUTvCMkqBZk7ZxZ7qNzWw6\\\\\\\\\\\\\\\/SToCnxLCumhs4toY9FVigPo5TYHJh9pnPOdD9ddoZ89Zo0Bq6nt7LnMHWer3I8cS9bGnDywsk6\\\\\\\\\\\\\\\/TDn2lPsuAGzMOlGsE70o++mPb6PwrseGLW0np0ccPLEuWoI+xwN7fLPiH0BqBQKdN805Kr2YeqgjqxLhPRB+lMExXzqrFCkP2720jj5mD9k\\\\\\\\\\\\\\\/Y3GTU3Ndh5JKCourITu5NrEjbzX6ep25jtrqoZ6JJMhTuMe1bHies5L0mgLLbpwxNbLn1H7We\\\\\\\\\\\\\\\/g+Sk51cFV8WNW9ryh36bhyInbjJMvD3iX+8Z9wegDKpKa3IXCz4OOg\\\\\\\\\\\\\\\/NC6vtYSr6XpNctoPT9aNecskUNmQSf0ELUov+KeECuX8WLg9tCGIEhvD3f5RIMCBSPgWSRM51bqUZmn9U3i1vGZrXjGfkSj9gAHnytBn2vvj+YeU4HcKcpso68z9SGMEInan2aMyfsRL53Ge1GBTTUAfz8h+vvszafIh4qc8Hj7VJrJsonIEdchgKyP22LOQhfMoCveHklsgekeuc\\\\\\\\\\\\\\\/UFpHcVy+JVxo3OFtkaseqWYKDd\\\\\\\\\\\\\\\/5tBy42EF8bgGM8+Tsy8IymKBRSqeqinD2L1paM2rrmETs\\\\\\\\\\\\\\\/acf\\\\\\\\\\\\\\\/BeyVaVcFM1pib0mYPILgG0MQr+ozvaqEdSGkPCh+za4ed3\\\\\\\\\\\\\\\/wV7MEMZiM1ZHAJOcq+0M7cBTcrR4mDVSCJl9kUARv30z9HP9q2RoBAMzna2CkOpN\\\\\\\\\\\\\\\/oxPvChgBPJz1mE5p9+hLIEzQHw2f0\\\\\\\\\\\\\\\/oECcqSvknBSDb4WR80m7\\\\\\\\\\\\\\\/AL8438hBaesSkyIGd+Gvf+\\\\\\\\\\\\\\\/yWxzrds5IHJFAMMMUU+dak9S+NH9lnN3IDHvxSAIHc8N5w1H57D44GvzCVuTPXfSMyrHRXYclO5Qcz3JQWCVbLRmNZiJyksK0r3sI9v6hI4ogKXv7ZWvHqsD4YWlLa\\\\\\\\\\\\\\\/zyaHwodnScKCGNYOstn+HwSPhhaQ\\\\\\\\\\\\\\\/oOjW8yCw5rk9H2WDQkniVRPbabsAX\\\\\\\\\\\\\\\/VOK8ukgtYSGLZ5Qd8cp2r+UUPwK84vlLUblSPS8e2HtlwDx00KEzGDgId9wJI3wvfomxojaf3lNzmdinU6m1N79t4PpcIeQvTmxvOW68Km3atCDp+lJZpd+UM+BfMdt5gwcdfI2rZ3GDElh8yg5QwhGjo9IWnRp8HX0TrBMURbSq2ug3DpzKb1NJ1TzowvEydQmefhNUn+bm8ztaKnw3oNI2YBVd\\\\\\\\\\\\\\\/VD7HzVn5zdfRIe5Hyc\\\\\\\\\\\\\\\/ZIoVJOI0oq4DSho4ccy6PziJgx+saiHrAUGcj3P\\\\\\\\\\\\\\\/moaxmMAerRUr9loDMSzT2vCuFJDNw3Pn+EE0VUet7W9ZHX4EUB\\\\\\\\\\\\\\\/zPeTIcGN4G05wn0978Q9DKQrXtTQtJ0QiaCRTxWwGBIg3CJonz+qdFbHdXs\\\\\\\\\\\\\\\/p9uZcmoK3KaBbXcRAdyxFLPd7B8NiHv7CvA1pb\\\\\\\\\\\\\\\/fC4kULvQrpW64AHT5pbNcCJeUjmVy2DdncC8LrTpECxZWZbQaZ6IckIZ0OJ+Wt2FdiRwgnyc70ApbQs1rC8vMk1MiZhH8Z1ND5dHOr+ht745OdcYHdrYam3DqQW62Xovr8jFpS4qNv6AChiK+Gqv9C1GWCVrUXMputrtR6M0jzag2GXRuEuyeTorriGCTMW\\\\\\\\\\\\\\\/FojVMguGW1\\\\\\\\\\\\\\\/kjsjVeESPOgnmJkJSyviwKQepboEVxj9rpVvMRMsfXR07xWpmbYJQHKr8CRPfTx3hMGocWqc67D+wgO\\\\\\\\\\\\\\\/26YlIKimOTOiirJwoQUPyFmii7vW8lor7pSaDLOkINFmqRORFI08mYErpqmK3tnI+dht+Eq9qoDicUhOkwUVWPVUhnX4yoGbqdALUwVbNqCAxnXLTbjUjq2ZKk53zpRmWyEPwqyZT6Jgzt+M5XJeaNCWOCA9M3Pa7fY+qH9PhZ6RAmuMSwXb+HHM7XEPGn8BFVq6\\\\\\\\\\\\\\\/yhDvxpgOGOoBEImSxp1PaCVozDqmLH7UbTL50uprvCDo67vxjFwkRqNk60InHoF92PTV5V8UA5D55h2fPol5oOJsD8xpo\\\\\\\\\\\\\\\/SF51vn7mam61\\\\\\\\\\\\\\\/4FYBmWJ+VlckpEzjhQr7RbBAWzhYCnWrWWQUKFN3rKogoVHQgyETn6LXZTMDoASAVsTMSSKzKILoicIchJu9arna6j6PIGcC+ybrgGg0fsTQWC73dJ37FTJBVB3PPllPo7AgOk3wAoOMiJrmzZ5eEpSuGjbwS6rFDEeeaNPdu5Wi0L5PdmS6Yp8Uxrm10ezx5V9clJK5PSlEaZTBitAAalRxZ8lh55AcBESKwMvc1La\\\\\\\\\\\\\\\/nJHbbTWBI8BfWIZ\\\\\\\\\\\\\\\/GDGOnwMaBFczxotUhkiPYgxBbEOw6T7eCqNXrJq5AnyaEJbhm8OiPXAQi\\\\\\\\\\\\\\\/xHcjnZZOVbsdvsGH3efVumZx8C3qVoexE27gATt5zxlvACGcKRE4V2kavuBU=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022CgRref3w2NHFGVDCGzhC6g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022e85278d8ae0326262b968be8a59a1f8ba21ee74d1664810a56e1cc08a38c1046\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/5\\\/1\\\/64.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/5\\\/1\\\/64.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-017-0266-x\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-017-0266-x\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-017-0266-x\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}