{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00220M+\\\\\\\\\\\\\\\/jdP+XFw8vjkGAmX\\\\\\\\\\\\\\\/XFjANP7NtvVGcX35p0rp0j9FfjPtF1AZeoWZFX9cGzPq+WSZp8wNDXpOLgX6bSZoy4tUN0xP\\\\\\\\\\\\\\\/D\\\\\\\\\\\\\\\/ylE+XtUM3X5CF5CmcjVTZbPnOxf7sb+rv0gzP64Yepw6CRCDGkFvvVo1lt1Vjklg+ULPJU5MVUkf0SzbrfqTCoFn3AEw80gUouk7y437EcXSJgMFo0cgAW2DqUQx2WmWAE9Kh\\\\\\\\\\\\\\\/HOG2ssvuK8Y2QQEfOseC5BJEbHShED31\\\\\\\\\\\\\\\/CbKMqeo3A2RX\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/dkI4gU+dZ4k7fLSKgMzS08k8\\\\\\\\\\\\\\\/Qi8BqloYHT6Pylc9a5NYnLsL906sLTsR2VvvhCz1JpAMICcIBwXMRcx57szDPeQdZTfbCflKyG8FitYEX0zgPCc+jypnXzapFHqLvDn91GA32WGiiAzoUqtLxSrnFvBDTk1XJMIvHYMR1Hi6sO7n99q4k+HsOC03SHSN4U1wmrdlDeWCUS4ImlWZeviQYmVcL0zEVqyC+3uFaQUawDSzexddeLhrPP9y2Z+hQBLh48Ep7g0w7ixghatOrhjWqithQOOj+nw1TA4XV7pGb5pb9LNdPY3fu2PadUrRPVbCe99BU\\\\\\\\\\\\\\\/cBKSKwL0rVOOJ5vnPVfdgi1yk4mJIoZQqUR5vQ9vqhiJRz0NoDq91FEdshCQ79dYAe\\\\\\\\\\\\\\\/PvsJN8gGSF5l1M3wZY\\\\\\\\\\\\\\\/I6LPSQymJzBJJg5eritEP+OZO9DtqUO419\\\\\\\\\\\\\\\/5zx4cHmhp+842gZ+5hLSAgsWMh3eDwVD8B\\\\\\\\\\\\\\\/mr2izM9RepgLQ7f1pIYhaLvjKWjYxI5IT3pOfzsotC7WKx2ZXw4gMYcY6x0fMayfU6ByZbEXUyujZP9YsoIwtr6xpT0dW40I2z2Hfx11hlPTio59tuyd18YaQNwI3DhK7Req\\\\\\\\\\\\\\\/YZnBrVrysYc77+rjaqUUrLpz+IvUx3b+0ndzlQBz693Yx6gEUayGR3kzst9yIVosOjcJTleULgp2IBG7cVxfvax8rg5tVW4\\\\\\\\\\\\\\\/ZUG\\\\\\\\\\\\\\\/mc\\\\\\\\\\\\\\\/U0e3DZUWsmgXEVIEwPH3doFgVBD\\\\\\\\\\\\\\\/YqUTRKI7i19PY0IhuWHucGVfiapUWwFbVLp\\\\\\\\\\\\\\\/UCPBo9iq1VYsPkwFWNcJQphnG45Jyt56esKeUQl1Fid8j5ZeOWZwey9u8pzU\\\\\\\\\\\\\\\/QPMbtk\\\\\\\\\\\\\\\/4ApxqEEHDBO0zpRo2fTzFpNw20ZKea3ybggutmhsNPrVx1Tk3wxgZl1cDIDZEe2rcZY\\\\\\\\\\\\\\\/eTp7yA8ew0lXNcU8ltkCcYKAf4ojfteeUTgAQIWc5Qlf8VS6sZ5AmBB\\\\\\\\\\\\\\\/VV0Ypc1iN1qZBny3K+nyCRmMSYFruUk0YgNG97QbTa0InOVNgYP0hRnClAUleKmQCvXUi9v7BOdD\\\\\\\\\\\\\\\/pRFA9eW5jUYgr3gnU12\\\\\\\\\\\\\\\/K\\\\\\\\\\\\\\\/CP2AwQFU86R7GSfihq30WLfM8cJD0pajhoMYEQMR5sukG1ZtAR23iowhU6IRJyH9xKElG6pxO5YE9VyfvIqXzDlNO9mYPkqmWG2pZjW+CQuO8A0ve8JWuR8pJ62QClIgBaQofYtq0dPvpHqteu7XZop6Oc1fcYLeR7yMklWeq\\\\\\\\\\\\\\\/u6l4lq4yTS+xLtL1vneJ063kjq6AMzNpDXLT1lA5LuOL85to5ou1M3oLp1dIpGIAyrBgq7y+O38eLIcaZD1rx+PKVgZD1IWH17gmvwubaEA27G+EIPZ\\\\\\\\\\\\\\\/jAJN\\\\\\\\\\\\\\\/8\\\\\\\\\\\\\\\/D8FToqY7mqiZFkZWAN4RqMwY9ccPKfwhlt0CeycgIXukCYjYBZGXC4GzYBXeRSv570fSh5UY\\\\\\\\\\\\\\\/AttwfkZAMOdOMaGdShq6eE71oySVKig9yMieD0UyHe55e+tsbmpZUAMgZ++0Oj95DlcccIgesxKmlKuLZvsm9ZE6RsT3DGMwbmr4Ztj7myPHbvBQSmOZC2VL6T\\\\\\\\\\\\\\\/9leFhu4wUShtjTyESfak2QRjS+FQib9UkPMvSJxt+WpVnN5pAmIs7T2+Ood\\\\\\\\\\\\\\\/YkaFQvuzMLhQHq5CKkV1TH1sCPQ+IV1XfU\\\\\\\\\\\\\\\/aYjhbQ7bwkDbulWUZwk+F9xo4GbhJJXxDyd206KTlsKy145t5kzYWIY52m\\\\\\\\\\\\\\\/yMOWkUrPwDSXdBHV9ptye5iBfh07NGXRfBQ26GLAUBNbiqtpzVHl6ulEnwk3ruPEZ+Rbc\\\\\\\\\\\\\\\/gKVu2wRZ9KiIu0z3OIZ53U942Ui+ICEM4aFsUapPLojMVHLgXf5nC2N4GsLQLsPU7QL6MQG4pKFqpd88PaXomkflFzH9bvBxY453mQMkPAtdWvuqvwhAbE64KBgA9zZFPZUGuXIVirvOV9HCevSI2oplZmjGyMF23\\\\\\\\\\\\\\\/zGtURq4vTvOiB\\\\\\\\\\\\\\\/FKPerMDc5st6IJeaknjZ+UpHpFMv\\\\\\\\\\\\\\\/eiET0KB3OYQPXRgpL+cNuWA2IH2Gm4k16BVWrqHFk9o4wG3opSdp1tbGy74TFAUkeu3yHagi8+CkLFP0rzoZF5pD\\\\\\\\\\\\\\\/PDf3GMqXaxnMIVvYh73oksCxUdceZTnjr2nvm9ZLpbCJOy3thjeyLKAPgMxHan9lOyfSBqlKL9orTkNKBvy2KT3j3afFB47KNZwBg65rRSZ9bkjTob+XFlJrgD\\\\\\\\\\\\\\\/rpX9MNQxEJ39xQa+xlp+hWFz+EAD585IzpybMzZbJwi9Ac3aqBPxWyeAP0Aqf2v42XAEDYCzsxdoUvvy3VnNv7jMb5+o0DLsnXgXySyQDwVyCkKcNUnIhXS2pag=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022Txjhb6Yate7VkofuTgmMlw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022de6daacfe350ed2c21783e963265aac1d16e72e6c28e5e965cb5ab10a7b4ee01\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/5\\\/1\\\/93.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/5\\\/1\\\/93.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-017-0298-2\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-017-0298-2\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-017-0298-2\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}