{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022hBHrQP85MKjck\\\\\\\\\\\\\\\/1o+fqvWbrySKObLeKRN7Qw9JZMkH5oH+TQUVte\\\\\\\\\\\\\\\/vGrz8s7rwtiHec+ttj52nhd1LqDYj0sGEyWjKxVcAU4CPiDEK\\\\\\\\\\\\\\\/eLaxCGPGJGUABit8v01vrYUIgNJnHkbTvZQER8b18eCW9GMGRJjiSGUtHW8GeDYY\\\\\\\\\\\\\\\/zaC05Dqq8N5nByNuVFpJogYhpCVjlXT+hup0bjv6oxNL5t5vTD9GkD2Q9lK7e3UjG15fMNm5pWQCVLcSJwEVKN5CF+bYjAeHhNPVkQGSulk4708DOUGSFNSN+azrd+QqYN5l6zMF4nXmdEK3HamFl73sQDFv1xZyvZ5VW4G69kNgRGJQmscBZSnsNIKGAMeobKFtXbq8\\\\\\\\\\\\\\\/gxW\\\\\\\\\\\\\\\/f6lxvjYSZ5H2Yc68GOxr0QKFT0vRHS9q1NPfh31JWL7wNKzGWRqmNWueP0gyya9QmK5OnYN58ga3qad7FHJusmgF+5RzrAN1jRxyc++u\\\\\\\\\\\\\\\/B3xsNXxgIBoRXNgMN+biTp2dycK\\\\\\\\\\\\\\\/5jLaQQEGiwCH60zzzPV+Q4ptdD9TyI5zFArxd0i00I9BcyD7PP6AwswP4EArIeqg0q9TUEX33HZVUONL3wS5+ERqEzAHb8wDfvj2fy7g\\\\\\\\\\\\\\\/2NFWmPQJWHXvG76Bta5m311MIf+rG9fzVZTnpXPdkLWyzlVgDzOodHCfz0HfyF71KSHZO1iv1X4JaNZriod2TWeJ3y8GOeG6djLRmASc1yjjfxdMhRO1TRMVSlQwc0WobltZzIXEWSGSBbZ8c1ElAZpLmHYvy6UWqDaVfkbTRlkG0t6K4w17z73YkpB1npd9oAwfVoHjplmpbYcrYleH+YtWhHsdWrWeXfLi7QMXYPw3ztWhAhVgsnSvWMTxuTZw4m9vXAylotVADjyHNZPOvITXNTZueYAxwsuv+NPYZRxh\\\\\\\\\\\\\\\/GDi2Ska8a2I4zYRsaefMperHzkMIB\\\\\\\\\\\\\\\/nkXR9jUpr4sdFxz2aKoAXEASDWTytvXyiSggXC4hsSt36RxUdPQGA7YHhLeZZShWzDhHcF4ay0dnUhA3Wgy6\\\\\\\\\\\\\\\/eFACuE8nXn13Q2vDxSB44ocS0gFlvdKKNov53N96tGOJoNJrIk2nGx3sSboloayQ1JMrkdfFnLZQE79CLYDaS4K1WecDyFX2\\\\\\\\\\\\\\\/CQLjLCc39xyeUdm8jvOUaG9ifWW\\\\\\\\\\\\\\\/JVcXrIEc9M3tQ1xB\\\\\\\\\\\\\\\/ZJFSbQGN5cgCdG8exmg1R5YT3oTCn0drbXQKmE79wgn+M+d+ImhmHj\\\\\\\\\\\\\\\/rqI8OGsU46iAJGwhQo3xGwXCkrIvvN5gi\\\\\\\\\\\\\\\/0WW54J524am0EA8\\\\\\\\\\\\\\\/nngY7tY1LYafuKyWzMq3N1dwFP444FOvxDjGZSywDDYc10EbGK\\\\\\\\\\\\\\\/4L1I\\\\\\\\\\\\\\\/4ze87k8yJKGTeRYRUk7t5hQQgeUOC6pBMO3G8KB4P50aJjOzbLszIsvP6cxaK8iDU3jLgFtAl9XHIW1mC8CnUZfD6ev50oXWAkx61kueIJQFmcVy4Yt7fGDnmNYZrYy8L\\\\\\\\\\\\\\\/pCGQ+BLEU4Om6yHBBl2hRYNWN4CANaxHofNo1Xefg4UNFWAXrJ2ghG1ezcPmls\\\\\\\\\\\\\\\/PtU60RkJ+gY7BtR1dtDKuM1yLfbMR63Qto1UDIaL80mL6LkgUlpU2N6QvHOI1Xmk2p1Z4MzVNYpMMTLfMjw7lO0cksznY645zaE8OVL19D3Aj5xB7SQiq\\\\\\\\\\\\\\\/3E3ejCA30S19fWOXmwqPldg+5++wV7pPLDycgJ914mKrlUtkPIwiqzGvT+kyRL5soc3W+4UZNy0gwZVCqvj+Tvvs3OmJvC+BQpsM+NZtCZIO2xvPoGb9Q3L60frAOAQzBKZe39RJW9G+\\\\\\\\\\\\\\\/u4k\\\\\\\\\\\\\\\/ESaiQe4Ct7gHu1bXKSHbo+sD00FyBjW9lglMEQfI6Fpy5Yv2DgPFeEJB+GAGexET37lmVHd7w0d6Sdg1a8ILcTQEA0QaJLLiklEvRxLEWd7maoPjYXLODMJcYXzPk3jIVjO0P0U19rOfv4pDbceZex+w\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/APMCgumeRGljMS35SOzZyN63RgBxsVYqGlrWOQQ05x3xCwxMx\\\\\\\\\\\\\\\/OT1hYrpAKI6v0tXTQD871Wfqdd5eOn3rorwVKmx\\\\\\\\\\\\\\\/3AiVIIsASupzn1oQn6CnISC0CSQXuVMcdREoyynb1vKSyy0lhEffGN2ROyG0AFytakGrfASiaRm050YBgPWdxHQl2UWhPOBCYE8CWOUhsEYpDwVl2XXynAcssX8XDui0IOAL9GdJTsc32QR1RIYePBnYVZwAJnkpOGIrjcs3DuTOIo4jYIIEobsMUBtOey8VRvzxMGWK1hEc5wvnf6gTsN3LWwNdFwNc7H7t81ci21tyRRJF8IEAiODMZg9ABKWaw63pgiw4iyiEBH\\\\\\\\\\\\\\\/iigZ9G25l0Yv5o58FDlX2F+4jV0c+QYFfClbZps1Sg3\\\\\\\\\\\\\\\/EcY39wCeBSov0KoMEtwbA\\\\\\\\\\\\\\\/mC0qjwPaG2ZToSCq9k62rcfssnWocsT4vaeHqBTSiWTn8DYg9tmKBfdReH05+Up+iUlbkVwOqhN48AbAhrNqVL\\\\\\\\\\\\\\\/RUksiH3vRB2WHypuZpWa33P44Lo+i0V0YUNU2QOHPZthoBkbKfsy8vK+SLrhNl21HvP0hvwLO9wN4YyS3T0CEnMWUsCe6cDIzRYENE9S6WiCdhC+iAhixJT4Lc0MyRqHOeqbiqw5N2H50i1if+heo=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022tKLRzLPmCA8gYM2kejAAgw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002222aaf5e8e44c3000817d07e940d3ef9cf96799cfea180c7c0cf819130d1975c0\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/5\\\/1\\\/10.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/5\\\/1\\\/10.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-017-0212-y\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-017-0212-y\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-017-0212-y\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}