{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022aCxtJfDvnT4rg5L86vjUAqMTN5MRzRfr3eE1BPC9vFk9HK6XKfjLjyF+aL7Qza+vnkR8kiSZb2BBBOmSpDTV50o9S5JB8jvz58M21z2vX4YOj7Vv34UwB4adIxdJlwCm4yI5wWTWU2fQ9AG3+77Zm\\\\\\\\\\\\\\\/9u6VdP5AIvotekv6EOVj4IBRQHD77I2wEAu4RsVlNKxZrmES6lDCpceiZ2PMYSnVTK9UYfsjIUuZr0q5aHawr\\\\\\\\\\\\\\\/yHl3BnMyRGaRXB5O2Wf+mq3EzP16GkOPqKBaIVs\\\\\\\\\\\\\\\/pkTejs8vMU3V+vkWTaE+U5LUPU2tkaBSHbK9mOOB3wmu3hia+WeRjOhiHHu\\\\\\\\\\\\\\\/XPYE+Hs4kkQuFeqxMd2ks9orAzsb7Rerb6y\\\\\\\\\\\\\\\/Gj8SZMjNJTxJQ1bBBdUnRtrjck+9\\\\\\\\\\\\\\\/C9BeP9i5\\\\\\\\\\\\\\\/jTwkhpMEykQo29xeyp\\\\\\\\\\\\\\\/QZlnEEtKOnANuVmYIJqHnxzci2MYFlznmzJC4bQLjGF2wwz1tRwbuq40YKVfQY5uJrxg4wunrA3IJSpUNJSUb4mdFOt9X2Xzsu0sEpWr3vRfIDum82kTAakyV85FMuacDTF+lYShEw6M\\\\\\\\\\\\\\\/PESpM3iWLub7We1cNS4djHHdSbfi1SocyJ0xVNvyppWmvZPXHtyhR+net8JUQKjNpac7zMk8OZuqzt82M2giPeWeO8NtVO4zapK3970TJ3zK5zOpb\\\\\\\\\\\\\\\/H+3FUN6Fp888neLLpe1uvdHT6J7Yj3BFAyW0w08bNdCnH0IU6\\\\\\\\\\\\\\\/5xcc53iQVVY6e\\\\\\\\\\\\\\\/nHTsB8xmxyhBvNnBpbGoHPtxugygIgyXub59tyUY7L58dI9XinstH+rjNB7hNbg6eLCkRrXz8wWqdLjRDJ1hLiOfs6GjYFPMOhNncei0qe\\\\\\\\\\\\\\\/XXg509pfY5oxkbCsgMLZkpOpJkytnk5p4lbex58orCiT3OE+VEJ43yfHD4MIwOozikSdzwox7ZvALZYV0CWwqX0RFGVH5dcKcmils7QiueIOla01DT2oyHWmQFv9Hwo\\\\\\\\\\\\\\\/0FSkH3LD1tviLvA4vdiHkT5PBpeyTg\\\\\\\\\\\\\\\/HNQC\\\\\\\\\\\\\\\/BkHPr4\\\\\\\\\\\\\\\/aIncrrY1\\\\\\\\\\\\\\\/A2s\\\\\\\\\\\\\\\/IPfdcRzjYzw3EmD+lI4B0Pp+d51o\\\\\\\\\\\\\\\/c0ysz9iTL4DCnT46OHEjjKQ0O3k\\\\\\\\\\\\\\\/NtlGePWUY5IF0iyh9jsX2vr66\\\\\\\\\\\\\\\/33bFLPWn6eph6Ad7MKVQyRF6THOXVe2a53lnax3Oqb1rBa30LYBnGX3\\\\\\\\\\\\\\\/NQ5Zr8R9q86VOFq+f5GOdLiGO803ZT2ZZibZOa+Ngcfia1MahiGGTlSXUFVMlsG9IlISH4B0XSXD1WgS8DuQV6TmBOni4N3UaEue32iUEgpqE7RjI9BEBa+0deWXp3OHU4bwLIC7OM1DMIMkvoYmaggpD4ItmpfA8s2p7zpSJ+jBRngsZUkMpbuEg27\\\\\\\\\\\\\\\/RG9LCUNAQX7Cz70BdUuoLlRMbNJr\\\\\\\\\\\\\\\/eSAWGbwoA1Nf9t1uW8VicMpjHJLUA0+4p2aHx75A7fdtbIqf718j0zrS7VR2xA0G1oVL58SJiMIvO1B2kmyl7jSv9CB8HLJecwS+Pbaa+ArpDj1uO6FZN04p4eUMRzSI6Xt7\\\\\\\\\\\\\\\/odz+ISRfjLbY0XXwW9s\\\\\\\\\\\\\\\/83m9nqzrTHil0IDvh5\\\\\\\\\\\\\\\/vnedqPM2d31IctomN2\\\\\\\\\\\\\\\/Hyq9GJWPjZC3dEk2U+ln90DVMf1YkW1\\\\\\\\\\\\\\\/urhPjnRB6y3qyDcyEZSJ3oGqThI1zq82u6G+ACGY9CV7nOjTm\\\\\\\\\\\\\\\/Wfwgrju5ZDeDo4kdXvadBrUAUlISxY\\\\\\\\\\\\\\\/4h+E4V9icY8q8FtM\\\\\\\\\\\\\\\/eGjGQnlOJHufBxo+kRlihVPuXkOa1fT2crTAcgIE5JrgbXsuB8iZJ+InENXtyCZf0fJxg84nL\\\\\\\\\\\\\\\/A\\\\\\\\\\\\\\\/v0B1oYIXtM5s0sbfbfcqGt0G5Hq1XOES8JI9Y3grI7drk7RDueFhSl4pUDHM2Z3GX2Duxup4mOQwnP1jTP7MPFumj\\\\\\\\\\\\\\\/aXI6zK12v\\\\\\\\\\\\\\\/8w2EvwyveixKNQmQgORfIGulVaXL2QrPSdSii+MGiWe4PouD+JzcYVICwTUzoJJsiY35f+0Zxztn+J6swKsExjnO+MNcn9yMnuEVrcRSVBJCylYdYvIPeVQdNdIv8w95fMTz0+\\\\\\\\\\\\\\\/AGehYL+MZ8lLANjHM3mcVHOcbCHzBVqsByoBuXnpQPOSawg1dkegMVHxpvBHqCCHEkwn759qgzw5l0hB+PsS\\\\\\\\\\\\\\\/4CYyDrjyPUHmRJGcMM7amaoShCF34TKE4ZTdpCg5TWL\\\\\\\\\\\\\\\/0NPPHrih49mtNS\\\\\\\\\\\\\\\/eB9+gWGuaHjOzhirbYM70o6a+pyy7NSNsF8ic4SDYNeZ8+mABQ\\\\\\\\\\\\\\\/LshppY+ywbQ3IoIvtsxL82bBH8E6Y8BPxvgZK2W3q1IyCh95G\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/OJuk2QCakVjnD6VmiOnFaXgQdJieqXiV+DugUIdgoYMiNKCr1FldBlLjdMUWdVN756zR+nHc5aq3TLptziDLU+0qdGNu270EW9Z\\\\\\\\\\\\\\\/jOm3EJKuif50FkDiDZfevcQ1YEVYZAIpw2A0yJg\\\\\\\\\\\\\\\/ruGDTt4+ShJMWRL386B6mg5762HoSOdVQA1VYEP55eRipTWCfblK449E41u68vC+5kuVhx34oyrMGa4ExHahpbVne97GKIIaF99chGKSRhJxc+qDz2+EM8adVqPbf42+j2eeGcMCJ6TC1Qhr9dow5AgpGA6hSQH44l7S3Z+O54bXaFJN+nFv4sDH\\\\\\\\\\\\\\\/sf9pE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022n+JXHTMIVc4x5QGCQ7Uprg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022dc7edfb73cca82f50e7afaec2ff1a964e66c3d4d74aec245360e2dd17be450d7\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/5\\\/1\\\/66.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/5\\\/1\\\/66.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-017-0273-y\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-017-0273-y\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-017-0273-y\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}