{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022LlUGbgFo1qs57MW+B+lMj9ahbhJAZWAOnJqZHmL57yT6MRiVHIzn+iepamZ5Fy3oSZh3kORWyzN4MVMIO3APvtfV6dtoBaI7Cd9D9EvstPENFOFCjwhfrIR6KMFSKEooml00MoaDOzdHCv1w2GDDzNErAWIAPROPwr9XaU7lJh4uqya8hXtK4EsVwqP435qmftfvDj8oD6YissWTf2ZWclVDPeHNFo0AzzgtrsoLg1stqJK+GQ9LDrZHIAKGO9y2kbYDR4ED3IH7gl93O2G0w7OBIIzdQP2g+q4wd6sgi1AIP7RzOx7r9qvN\\\\\\\\\\\\\\\/u4KkiZZWtXrulUc3am8njL+Vlz25obRoFbxhSv7TS6\\\\\\\\\\\\\\\/jy89Bjg1cJIs1BKAlmMRbYP3CBGNkvAxFnUH0+nxFc\\\\\\\\\\\\\\\/zq4MqWo6AGZTu1vIhEGHdS5pvq4OL7YcqVSvzrRAvY\\\\\\\\\\\\\\\/pynVv8F0T6r6+eHj7mVyDLdtvLkDlV+O86WruSNYXrMg5+m6kKFd89q1HesOQBt4pfOpDGY9pVJS5HXWg2qucItdR8Em4ETGP40SY13UkaQ1hHQT6zFYfNRL+FGyzcDd71UX5IvL3GqC98nysSzDoSz+AzvpUPnrrUGEGiGkoyfxWO4eLODZpztUtwisfZ\\\\\\\\\\\\\\\/ANqytOkjuKA1ps7O9O8JEga6dtPCFD0z26FJT9iju97U0n0yq7KEUBWX4cxFb\\\\\\\\\\\\\\\/6iLXpnCGRY\\\\\\\\\\\\\\\/kHAx6fItV4iafdJBxZ6bDCfD9ZbaKVQDLZ278LBLMp1S3Qy2belUjcnlpj2WlQd68xa6BmCA+cazBpAM9TALokz67Mnew3w417QIB\\\\\\\\\\\\\\\/ANGjUIq74FQwbeGUmaosUnwXe7un51R2CJCPJvjJhFn1sNqUQi5dH21PRLecQeCWlHLhMZRuugiCMXgpJxTRp3skjmgKyEd\\\\\\\\\\\\\\\/LPsQx8KBAcGV4OU9HB3EVm31EnOtFhTVdxqAiAB6WsrslpH9IR7Hzistwkq\\\\\\\\\\\\\\\/9n3AEKWyc65Y53tO4oIljzrLJcEqvlHh4652fQO8kPfPtA2cuxIN9aa4OES4\\\\\\\\\\\\\\\/bfMpaTadw4qDnwTQmnzju4\\\\\\\\\\\\\\\/q5J4+yjw2\\\\\\\\\\\\\\\/qaJY2hfvIzPnsVuDFXuvXqly+XRfOFeIlRDDsqrgSD1zxm1Qh47rt19OEUbex\\\\\\\\\\\\\\\/afkl1c2lFmWDWpkvHsR1ozcXVgsfZuvEK23Vt3o2r9M+yjZGeCiRIX2y3MRIHW5+jVAKWZ+dA412ypbqekqog3pemjMxZg5IQqlROlrTTNoM3l+UUpKlJZpEWyvhPjBoGL5HDIzy1WMSS+irxuR5zwMaL51QseyYDJe6w6vWLc6CvwlE\\\\\\\\\\\\\\\/jVcxuetDX2eALGoknTyD3Y90KmOP6ls94IkuyMXjtKmedEfsInQ8jLZJZ7FNPH7Jb+1Eqf6klO6matFpD6mjq846VqF1j22W6hBie15XCZyis0jZeDBhn1pQG4tOiWIj9kjQPrrCgP5mNnVG8f3Os5DCcDt71kMplpobcYYWMVizsHt5IQTxW98brxO4fglD6U93EMmLW5O5ikuyqBqWvUdz4YhcP9RMmsy+sspOFyk4flmZS14LyoYk4DIQLI6iB5027c4e8dSM+E+ZuDB1zkRUOg78YudD5JNdO9ZiceZs7n\\\\\\\\\\\\\\\/8s0pjak2VX0Mtb5xLIFxahnhcMcG\\\\\\\\\\\\\\\/0nuD3vf\\\\\\\\\\\\\\\/f1xwDxFctAtshOuc2ohap\\\\\\\\\\\\\\\/i48NzaqEqNf+VRIJZs2an9EYiVlIIPS24W7A9LA8x9kQBcvwhXkzKV\\\\\\\\\\\\\\\/0nAl7uGkOzG1\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/ccopGrWGm1dY+HzGkvToWMaKOEACyrdw2M\\\\\\\\\\\\\\\/ipNPWLM4JyRZ\\\\\\\\\\\\\\\/wXTtkK1+n7wr8N9a\\\\\\\\\\\\\\\/aE9CHoBI5nnn7q6dNvnpmg3R4eO5B4mLa1GorbD9wiG0cR9H3NT3JVbGjFdj3EcV6lkkGzNQ706KuLMkfachdzsD2LbyVVhY0FniiivpDhKZ8s7ZsloOmpOBw5FMeXvlHWmbLpnHCj0nXX0sc3soLsNeMJSDKmJd2VJuyzZPtm6gVLkdQcQOZl1anO\\\\\\\\\\\\\\\/jhRty\\\\\\\\\\\\\\\/XBgtpIslgYrrL8hyH7a8m2sQbPOayAO9IIBuLmQN2EXsmNCTiKMmsEL2b6asajqfNUbLA8WM8J1xMPKnv+E01RABgjSJcbAg0brPBtmvKdH5J+bWIN2cBer+tLQlRTK70g5r8EH0w1x5oVwz23EfPYoMnOJItJNGigGQ4LGs5D6FEqIHKfLo+q4VbDW7arCC3qhsIJ3HmEPMHNnCXSXhQZsseOjwLDsIZ6QgGHM96CPBXyz2le82rFv4qt\\\\\\\\\\\\\\\/Ctu2mwaOvsW8oIDeS7cqhDQ47fN6bgEqhIpY0YNsjusY9wUQR2qiIS1Y4hRBSfBgBHEbwxC2438m++96nHPY3TzPiXQ29gYWRAyc4ce0mPR+A8gcPKA1ZaZM2LOyLLFucTUjIv48wORqxb0EVRhDGifP8Mmz3k2BmxjXFRtQcElGaad+ez189Akcs2Qt+891agnEmuaMJmtqSsXAXuKmdXVKzJrbCzQ\\\\\\\\\\\\\\\/AyFUvLa8x8bEJnytJDyUQmJ8He7QBj6HrsycQt1tGtsdunoz5tj4ygrpfEBSp4C4phU35BQQVTkSoIPK4TG8QXBsOIgbT4whH3GusW3WFhNAyvccMytYDB87vY421sCLmu8KOL8kPIWCrw=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022x+IpbZ0k2torXIqeM4cQ+A==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022569bb3cef7ef6d8cec0e230609081aa78b342504f31c4479ca6fce51535ee3f3\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/5\\\/1\\\/6.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/5\\\/1\\\/6.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-016-0207-0\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-016-0207-0\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-016-0207-0\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}