{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00225kkRWp0CqghwhgtzGKI8vV9J2nRhalJhgMmHn920T8pxrQdNf\\\\\\\\\\\\\\\/S\\\\\\\\\\\\\\\/soDSClm9iW2cOD+GrH6BbfddjsbmIbfCzizkg8VPHOT0Zx60+y3pk9iNcTiRRfzDG6aVHkpzszj\\\\\\\\\\\\\\\/0I2FixA+\\\\\\\\\\\\\\\/9Hf1QvuKp79okgS4jK2vhYFMSOk1REtXAoobyCXYVBHGTXqs7XiTM4VN0kDrIp1iwpSSe4yz8kgQQsAP7SsJVZ8K5vrZ3qaURjeDKes2LsZ1EwvwjwSa+SkQ8VxYbRRmCecXVUZ+wyxBlYZ3j8y4Qh3J7fgZ+gP0MJEye1ZHgHgDbmvypH12GXA9icrSmpATFH8flYgGkA7FApkl+TVSNX3O6D8y0a2q4Hirr1KR95O3w\\\\\\\\\\\\\\\/nwcY41bOo9EmPY7w0WzZMk01nCx5GX8ASM0Jzj8as5mlAFIEOZeG7D\\\\\\\\\\\\\\\/BlZLi1OT2nPuCcfvoyKgsL7uFy5BP8wJ0Fh4252Z4SCbRnQz76gpbnPQeSmGHNY2Rvm6nIA6ZXsPOUefQTgeHdZY1uSXSGCtj57cuoRdzaArI9qmhWSr+bum\\\\\\\\\\\\\\\/fRSJ\\\\\\\\\\\\\\\/jSPO3QxBehKpB\\\\\\\\\\\\\\\/5XBLjNc3w8qHzH7nTis2aExb0kQDRPfYfzsrTYyZaWwumzvLNwSbT0XE7r+a3MvU0raKHOey3e3yUqNFR8f\\\\\\\\\\\\\\\/UDnR6\\\\\\\\\\\\\\\/HKAOo2LSvzIipMj5LBbAmtfJVFu3YM21hptXYVN7ltQZPbSZvBbmfs1uF4ZCAYBqHDQ3JrF4HTqMk+5UV1VYKY7umVZs5TGWGAUdvm3UBWB0yy5rOLMLlr8GDeh18LpO+5Vr8eZJ5kxRfFVr39lstDHQLlgdCqZWPevK18wER\\\\\\\\\\\\\\\/5xrmN3I++pE0z4I\\\\\\\\\\\\\\\/rCz4Rni4lG0v8ZGWhkZcD+ODd7OZpyeqEq9qGLyG\\\\\\\\\\\\\\\/G\\\\\\\\\\\\\\\/P6z\\\\\\\\\\\\\\\/MYGti7eGy0OGtbGNsAxL24mWDTQTCn2\\\\\\\\\\\\\\\/yY8avVGuQCCfgVZpUy+8gH\\\\\\\\\\\\\\\/UYvI20t0TftTVpV\\\\\\\\\\\\\\\/bdX6dg2OWeIaFUcQVlBtUDt2xcd99RMRtEcCu8B1U+RzpXeABL+c2ii3u+geYGQbQ+lwW6Kev8QmkpCq15kQOh\\\\\\\\\\\\\\\/mj+GSyL0i\\\\\\\\\\\\\\\/t3fsSP0tw78FXHbQ2Mg0eFEAIY7mYvG6Ei7yZMGnDdnI5YC1QHhkcJ62KvqkLbmK9zX9g06JMS0yRDf5INkgq9o5PkPsII7eXU5wYUhMKbCwkZ0ihILJzmHEAWOwu5p8WaUme23PzMe0qoNFCmekfUzXZHXlKNwgBPDMLXEQK3UAD+K0muSOPEdSb7LafNk9MFnBo8it1g6Vcn2gSU4lo\\\\\\\\\\\\\\\/X3smzlSrzLc5MLrJPvQQ1dGpIHUb7HCDqySXUfY8V9tPmAke0ICz91n2EROX\\\\\\\\\\\\\\\/ss3i9ObmjxcXRct5Q8gjdLOsHIWgFwtNivtovNBzcTtaS5jIT+Ob9KhXqJU2NJWjusw5eV4rxssNBbrkCv3xrhRnpgKSG9OSWs+Fa3fTM2jxBmxFDsHH1k4TRHcT1+gDm1YgAH1ZUr0Nd4YbrTUHdNrSIgPywHA7Vg+eRB0vVUM\\\\\\\\\\\\\\\/lEcEXaHPu9J4ioAA\\\\\\\\\\\\\\\/PdoPESxMCJXdgSAbIG7LP5nNIub7FVZIif5wy1onaPAhEmBZp\\\\\\\\\\\\\\\/VAbyia3Di3HHWo7Vb6TShKK1KwgexPXtHdHDF8I6nyOTJOQAihVcMrBzbWb+6Zp0czMXqGKc3zsGCOuCVuCqr0VWzXI8LNvUBkADn+Vora7DY9l+GkucwP\\\\\\\\\\\\\\\/PEHogmcr\\\\\\\\\\\\\\\/xb+J3SpN9OlaP+WSRwVgKeIEfcnG1aOo6G1FJXj0d1aGaf+obMlNwj07A6VqoFmU+ptPfp3HD3\\\\\\\\\\\\\\\/rx6Nj\\\\\\\\\\\\\\\/p965PKKBy454tT1fulQpRvRgV53ruHrrZt5bqzo0DM2A9QNEEjX1mdKjYu+I\\\\\\\\\\\\\\\/OcwYZHg1niK7N0w3ChO9SbWlxk1JeyTqFdLr\\\\\\\\\\\\\\\/kbRuwU\\\\\\\\\\\\\\\/WdLej5yUHYmAtUTccyANRoE1K1E\\\\\\\\\\\\\\\/6+PGmh5wSNOe+nKdXaDGxYmVyPIFRa2+MUzPrA0MkVp1raPoHLgPGPtoPWDI\\\\\\\\\\\\\\\/pow2MWRs8QTLeJrtj4abWgA\\\\\\\\\\\\\\\/YBHA6X+Kyur1ieEC9XgsFCM9GtAghbe0iJ\\\\\\\\\\\\\\\/MoE4pBTmEJGR+3ZdTs+q988ybj0Mc8a8v0B+ID5CYcbmI355AlwaUYKmgtSXxbqT2d\\\\\\\\\\\\\\\/aQw7G5+Vxit7\\\\\\\\\\\\\\\/WMcVv4HUfuJ\\\\\\\\\\\\\\\/kwjJNaYsj9lOQArUM\\\\\\\\\\\\\\\/q+ALzk0nZzJ8KbAPh3icfV4eGfk6GChToeXeLn5kcQkbkXFIRJXVpNGWub5mowETZ\\\\\\\\\\\\\\\/msB\\\\\\\\\\\\\\\/D5\\\\\\\\\\\\\\\/IgJpsF6VMM0o7D86+NyNN+KpmT2n5f1bUyhDhUuGwWGBv2v2pgEx2\\\\\\\\\\\\\\\/kNl59loTB7d887iMTLdJfDv5A37eqSYZR8WGEJ5fRW+fbA\\\\\\\\\\\\\\\/iBfI8VnWTAY0nyXi0GSG9X82sP+zYeH+TMoZtdwpjF\\\\\\\\\\\\\\\/Qq80mRqI657tX5gs0B1dQQrGvWfhh8I0ditv8Ok6kCD5Y3jNEitAq6lQaiYCLjjJO3DePscBwl+A64YYq8GFXPfHy9iEve9QpXVf4XkPvlMJO+weOiX3B5JsucJVWUuJ8Po1kCASowyJhwL8k\\\\\\\\\\\\\\\/5Woqf9BOKSXoH6tDGQ0IpWsAwyvhUw+7utlO8w1VSaxY6KTN5EfQMf8hX0svONu2\\\\\\\\\\\\\\\/iWHp3tWbqmDrhgH3QEhS3VUWGG7o=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00228m3cjnlN8sC0ZRMqh43iZw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002230cc2a6ceac803c4107223801628c8e59481cc3d4c53d494bfb8096c0d974513\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/5\\\/1\\\/9.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/5\\\/1\\\/9.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-017-0209-6\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-017-0209-6\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-017-0209-6\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}