{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022ipkGoFrNiZCNEJlh6FmSCrXJIGIPfVOeUJBNlN7JME2dk0v60UJjG87xQM64vZgo1jEhHswppo5twRSRunzDiheEwSuHwy6nzXp8DVfShCqi8NY\\\\\\\\\\\\\\\/fGGNELJUYFzjQkZFmLSdds2KR7XitMSKOIUS9oLYvUZ9EsThV+pl1AgHwDRrQaZUYXLwYVIRAWdSTm5cUoDtQFN+gcmBQGGOMisBj42AcwH9rAvifydgKyhy93nHteO+xZjANSjF+I1Rjjd\\\\\\\\\\\\\\\/qaQ1cFEo++B34\\\\\\\\\\\\\\\/RfrQKsxbxdBRN7lG64W1PR99qHGjqLSin+Vw5+n0cXlvVyC\\\\\\\\\\\\\\\/EJg7V1bRekV6AaxRiHiJ\\\\\\\\\\\\\\\/5mxaDSjjoBvGH0Gt39yn6sqZCpDYu3ggZuTC2VT8yeShIkNlA4ss07aEhMqfRiIfASVuJrveDimjEWYhEdVfakm+xpc58F7S8kyqKMbMO7v1NWX28aEps+CmNVNMOf3iaeA9OIzEj5SQUpHHAT86R2oOYF4gamC\\\\\\\\\\\\\\\/4\\\\\\\\\\\\\\\/zj0ewNkmq5f245LWoqifRlXVZx9ESNZE91PRao7ECSXx9Io35j430EiYGMHtlhRft4RwslSoj5kKSLhKTpK\\\\\\\\\\\\\\\/yoU6\\\\\\\\\\\\\\\/E2o4+9Xi0WKfd6k3H2PpPpBNr7nftRksW8PaWprLfL3+CpKWc2Mfa7++sM2rQqJPmK9e4E1tzCGGH0hEB4BcyeFetWImpyEeRo\\\\\\\\\\\\\\\/EnvFOU+UeaIAkSVb\\\\\\\\\\\\\\\/CjvwSsz5YLFTd8Kzhgai36Pd3UIm5YmKZmpTiQSfVtWMcccOizJxrDSJ7wJHVgowAzeAVjBCjDAl6YUXYwy5Qrbz2Wu5JzhaT2gttO4lKdkzZdS+bynL30mfE3W\\\\\\\\\\\\\\\/MJkH5hxRy+6vOupqP\\\\\\\\\\\\\\\/OaUrtfRxKxAXaQIKaKCUjQ0tpR9aIdM73A80aWfkmfqFixSmI4av09bFRgnKvVU9gC4yZ6NR81sC0G3LvYMjWIqYBuzdmJ3V7V11QQDWTF209bjXUl4ps2ZduatHGa03DRFeQvAjtek\\\\\\\\\\\\\\\/kUtl5KKSxPvemsnnD+xfz5KZ3D44PnyPf+1Wwa2T1iNHdtq8rj3vImojE8KAg8bLbvQa\\\\\\\\\\\\\\\/5GIXZWaIPVu\\\\\\\\\\\\\\\/DoQrKoqLk7AlngAHdKhTAdChDnWDqPaEdR\\\\\\\\\\\\\\\/f3koDiTP2ePlMqavqHOj+\\\\\\\\\\\\\\\/9g5iSlnDkEjvk2B+J7jc4u4Lr2vBrNI3U8ZeH\\\\\\\\\\\\\\\/YSEsrJ8rM93SkSGVg+eT1JNldGnSlt9BxXfuAeCjp+laEs0nTJEe6yDi9c+3JNRCU6LECKHZuAEv2TfHdVZgTOjEnX0zgM+tC5K9wW7Xt5DvvptR7dli50MBgcT4Alz\\\\\\\\\\\\\\\/0gAMDQooa9NH\\\\\\\\\\\\\\\/dHOeOpNEvx8rZ08mUhRAbxqDio8\\\\\\\\\\\\\\\/cu940oQbDSETazmrQneq+CMaGOaiwqTVS0\\\\\\\\\\\\\\\/PDjXZyjBrDQfraeqtsmFPUyPZhTC7z7+HAvpwOIMPFTvIevNbU6w82EfhD9DFvan+FvNK5Q1bDnunqmq40TvsYFd6u3uzWOkKmDc0uludxFfOUTRUkXuBICL6EKSGNzAvOsPZD3XMqtfwdkruVEN9Sw2\\\\\\\\\\\\\\\/V7H9WOivEZm+yr4PIyHwt6D9tzo9NQecncpFCwWKjhwQM\\\\\\\\\\\\\\\/DyiiEMrvVaRAXCs+aVthZbQRZj\\\\\\\\\\\\\\\/Zhd0AQxMedvPK9vBIYYcYExSczQyNyKXV27AYUWazGsKDa9+5WzYOToHFtbOPg7wWgQZ1N7Mz9tshdmUVoDNfL\\\\\\\\\\\\\\\/XiOpLjEKhKxIa9v+KrVbAQTwjHqNLHaxcEXEGPCWhpuHcGilP2Zc22x4IumIKmyI47fmyfoIL9rtxJU\\\\\\\\\\\\\\\/dHaCwlX6+xsrnQmimv5jU6ATZJYLMr71jcycYOxAKMtTCu3snJCZIVTBHVUJU4DFZK7YVed2alXZWrVzWEJm4pUmaZ9qjdTxdEAfvH0+ZwaUxfEg2Oebjh86GbnbOvThFZ7aeQuKQPea0GL\\\\\\\\\\\\\\\/FZrT8sqTXd4frTSXpwI056WHL27vg9sf\\\\\\\\\\\\\\\/OaZayuXeEPK1VS6Ly5I9y+xyIeZpr5jwLvp633Muf3cdX0XHsT6Hs0dSnWDF\\\\\\\\\\\\\\\/h0P31GKOISS+xvreSpjI4fCv3aINxDdurjSGle9Atts9fX9pbT8dfKdN+sFHdpnQ754H7FInizSb3MXsukI5jCDvY0ey\\\\\\\\\\\\\\\/TTO0wrIj9MVfTbD53jKpgakpXimHSFpjMG9bnowplUk+ojY\\\\\\\\\\\\\\\/LDxUlQYErJWAebWIP\\\\\\\\\\\\\\\/ODd5EDaJkocnH5RoCxaKkcmFLl2uG4qTzpfdLIUs+YHGgXZKn+XQ8zVTaqwNJTB2m2CYh\\\\\\\\\\\\\\\/XOlxXZxvpVD2erGcy592CasJBaB\\\\\\\\\\\\\\\/+nklCWgI7lH\\\\\\\\\\\\\\\/vBUO6CdhlV6EYGzcMoys+2lqEM9rv0lOo2AqEs2ExWYmxE18gfPo7JAKYwk6IHw6J1Bj5yrA\\\\\\\\\\\\\\\/YZI9EdyZ7AVr1o6wI8KyHkZ0Md\\\\\\\\\\\\\\\/7hBJerduwk77w0zpzH9wNJRDVT7uKPJTlgf2guJ02id3i38vWjAAEd2RRCPw3GJmz4zuNd5PYdLWYlg72t4VFkL4nAk7ReypwGlSyVWEbWDEA+MrhlADSvYvRRXXGeO+oY+HCuhNKJBGYSOWxtf1\\\\\\\\\\\\\\\/4dp5UrTUll0tVcOf0zAx8QSAfZgOBlOI+Kh\\\\\\\\\\\\\\\/KBINcJB43PcSKq8Y4hwboofRaYQ68smuy7\\\\\\\\\\\\\\\/9\\\\\\\\\\\\\\\/EjWlzLylU\\\\\\\\\\\\\\\/Euk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022awNCPLAj0h\\\\\\\\\\\\\\\/XUHQXvE8PFw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00221104179f7508810481c933f2e9644cad3d131bc9eadcb554ba6c30632a2153eb\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/5\\\/1\\\/3.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/5\\\/1\\\/3.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-016-0205-2\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-016-0205-2\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-016-0205-2\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}