{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022nEXbuWIoEhY8GvNhJ+c+Vh4m0xObwoHdkSXi2GlrLYld4UWR78dDITEsa9X6uOk\\\\\\\\\\\\\\\/WkD9d9wRkYCYfMLF5hvRNTbZ57grU8lzRtiScpZoi1ntVRslmP6M7cqhhbNPX6q55uFboYEbGZAYD\\\\\\\\\\\\\\\/xQn5imNgSMG594Flc5Ci1KB2aVMt1dtyuTpxDEM07fBUw\\\\\\\\\\\\\\\/9TGzP5pZqguN05JbVsYn00HUwqGNviXmaMFX1YNu4sylu4P99Cbs\\\\\\\\\\\\\\\/TrCQu4Slmmn0f8QF6+45nPEa+wPwIZLmFVbywOAjmdPHBgIeGTizNqCNrh8qKWV7FMHhbJp6rN5CJUz6xFFbWrIpwOpu0nAYpPDRCYBvF31XMQaFyvyUNHD2EDsK5SOtKYJudjJjZPbNiaeeoSuweoTveRDLfjmXfyeuu+IgwwDWj650PKnC\\\\\\\\\\\\\\\/1T0ttgRzGS2jifoIRxHPleoiybhFGxOcHdvWf+RRlRIFxFpAlL8+WtbsA4YyTZr0cxG3x14eneXZRY4vYA+zE80seqONkyCdFPH19RXpZ77e0WLKhNZVLbi8qqROVtMGKEO+qWtJtL69y2aW\\\\\\\\\\\\\\\/xLF8jxVwtTHtyPszG9CSxUlB6ov6yiX3z6vwasgG96OtuTHmTCfQ30ZvTvyHt6ZLn63ptYG7J\\\\\\\\\\\\\\\/E8FlGFnBSBs4jPVlhArMFQ0esdd7tCgjp9V0hvPGCdzWi\\\\\\\\\\\\\\\/MQb9iLSuDSuRsxQFTIgwV4cgWw9Lxft2Mb\\\\\\\\\\\\\\\/I3yjjb+w94CfohDsoI8M4M3fRFUF56Stefrw6zzVos6KqebcvZjZEp0x\\\\\\\\\\\\\\\/IH6CXs4svKHd13Wp7gFHFG57xhDedWaxxWZNCr2nKK6HGV+gR6\\\\\\\\\\\\\\\/iQ3sc2G\\\\\\\\\\\\\\\/M0DPi0aNEB1PCYqvc0OZauZQqJx+B\\\\\\\\\\\\\\\/9aAGkI9oDrWfcb1xfOZAzphzKXAs8gDyok5NfZJ3o56N3zdwUl\\\\\\\\\\\\\\\/VgVwlJRwCXuI3TrS6+P69UFrBvV32fdY7XU5OPnd9hvT66yhZmFbmB+Tp2qk7txPTePQjp6MdM5sKbxxLoD6LynK4Q80od37B3Kh7QYcMtxxaScY4kNXP5GWZa3WeKvcx0oU+H83uoN3l8M4tmHSuqKZ1RcU+FG0xbZrYHPEBNcMzLLoWEU9Hrcw979oR3JG3juFgjKLJq9bFE5UWaKLnY18QPUekZIRZ5TE+yMYjC4LOmvLLx4Xu2B0ZkE5dO2CFT0y7ibzMLNMuDavxt17vkAq7yRUZmR0GiCUWIUSAeNEtWEx0ESv4670jioaGrS1beYrA3pouxmUK1MbykhwOAInxSCv4rm+zIt1WEv7Mk9OSaeTfDIK8t0SBqNNQgaJtLxKVyAYw6IdekJ3RHFvZi+DpvoOc0qBz6TW2xgl2A7qnuWAuYZ71\\\\\\\\\\\\\\\/cuyA\\\\\\\\\\\\\\\/tZgiiSnFY14PeGVnadA9NbNFsXTWEY7QLZB1AYI2MPsPo61bE9nKfjQXCFNhYUE5p2joMzIUmYxlAy6N26iiKFjRb8zgzRAcQsNmquczM\\\\\\\\\\\\\\\/6UIhYgZddMOlYhuRNpvTKZsuqYwcGd4UmpM1IbwM6YWY5rq8ew7RcOh5an1dJyLsUir1fxKxtgMHb+UXDXNXGyuL61UviE50cSQymq825BdL1Z2MHpgQqTTySQJ\\\\\\\\\\\\\\\/S\\\\\\\\\\\\\\\/ijcUhfXiifhvrTkVCAX9kmekiiKjykN89CxVOcRqWe0b90Vl5mZeItD2Zsu9DAd8UZ9iG292wHMwSIjs4A1jDJnsJ\\\\\\\\\\\\\\\/wChp\\\\\\\\\\\\\\\/NAlOXep9\\\\\\\\\\\\\\\/FTWpTtXb8sbrIFroYUWK+xpfXUcekUYXJjnS2lESSnuZEpTZ70MiMmwHa6TkJQu9GNtTaPYDBq4LbU4FC8qYepQa03QuqI4peId3w6zhjJ8lpkuN+xNjFaDcOeZaur9pqrrrtGVsDfUvg5nnPFEHP7h1KnlKUDmf\\\\\\\\\\\\\\\/ZFwC3kee2yKH4NJen+ZY23stZn5+chaia1+1HHaaIri4r41\\\\\\\\\\\\\\\/nORaPFXteuNsZMftA7TaVEFfq3p6d3kjalHeCT88+REsrQhjI3Hw+Y3i361jj\\\\\\\\\\\\\\\/L7NQ22Gfn8iPxaLYBH23Sk96RT256j7hIF75sjytz1Slcpnawb5JkYIk6jguLAK8Xn9yiPuqKKM579HdF\\\\\\\\\\\\\\\/wMKkJI0tKydEUnZc0NFSmZryDYgYdP7j9MIns\\\\\\\\\\\\\\\/bsSTOlC+Ujjmg\\\\\\\\\\\\\\\/G5q6jNG\\\\\\\\\\\\\\\/QgwwvoRGLZ4grJWefakXOWpbAxIUqs0Os\\\\\\\\\\\\\\\/m3f2DiyOK+m4nas\\\\\\\\\\\\\\\/5z9FX3Repjvt12mPQMvE+fBjpIgC3fI+7kUIGigIsbIAl\\\\\\\\\\\\\\\/36DcmQRl4uO5xsPf+7y2TsZmwX\\\\\\\\\\\\\\\/+DoJBdSO2\\\\\\\\\\\\\\\/se\\\\\\\\\\\\\\\/bF\\\\\\\\\\\\\\\/38h38UdzmQrbrcayX4QYq1d5cU0gspz7yB2QGuMDLHBJMwsDAmEvb15f0LqrLpeU+9iZgm2LacvNYDJdvuKHBK5PIiFENZWp9uukh0rS\\\\\\\\\\\\\\\/718NaEFI5bK\\\\\\\\\\\\\\\/WxJEWzRGHcd5D76xnB3z4IgQ31yLrUFbYkUw8T3\\\\\\\\\\\\\\\/aAWCldrPtMaszg4dE0MbsnnK6yAHy\\\\\\\\\\\\\\\/ymTNeEyTd3Z+EctqbKiy9zWnv2F\\\\\\\\\\\\\\\/lpbaJ3mwP\\\\\\\\\\\\\\\/xFL3f4s2ougqiwFrLLZTN48FLsWxZ\\\\\\\\\\\\\\\/7IaRp2oFuI+UfKuOUfFwIpVNFLVW63R6C6ChtTlmQyv6SXI4upOrJhTMr7sxAqXFUzqfgG+SiECjNsvfVp1g620vSiLxV8s030=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022x+i4sEWOcRr57A72EpExgg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002229a29270064a23e7f8bb88470135b89fd1ce029ab05056256a82f9c218d93a5b\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/5\\\/1\\\/49.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/5\\\/1\\\/49.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-017-0252-3\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-017-0252-3\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-017-0252-3\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}