{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022LPOP4QHPg1402pAUqaM2Tj3MrnXsYBM7SD5xbdjY6uwaVKLBcmIPvoZbgc0f4thOq1o+USda82GqyxO\\\\\\\\\\\\\\\/at6ya0mHS75c26BQdBKmOkqgOUPUsVWLk2gUwo3EWAd95Hfdwk+fxxbs6tL8XCP+n7bkmCtMXR9I3L4ZjFFFencq+8HDzzCi24OU8X\\\\\\\\\\\\\\\/HNQPTzv8ngGQ+SDw3bBNXSADce0aJ274Lu8FgPKiqHJnkxV8PDHOxfz7cN+nGFhxAkx2rdDGU\\\\\\\\\\\\\\\/aVBgizNW\\\\\\\\\\\\\\\/9JiCTuTl3xSIUlPos533nR071udnJHsg8O8abGIODikzEzAmJFrpxMoQv\\\\\\\\\\\\\\\/gMk5ZXIb6FHPn3Flc1CcC1n\\\\\\\\\\\\\\\/Tw54EN\\\\\\\\\\\\\\\/87mAK0YR+WCV2g+eXR4KvCWI3kGSzaA4H\\\\\\\\\\\\\\\/6Zz8vowe88puxm\\\\\\\\\\\\\\\/4eM5HLMPqY2VaLP1ceTz\\\\\\\\\\\\\\\/28PIw4ttlY1YkvureUG\\\\\\\\\\\\\\\/lj6lEfrmzmiV1AP\\\\\\\\\\\\\\\/oVQBErXnE5XH+zyeLPGvxBM+jS4cTgHvvTb5GU2UNwf7JyXTBNYrpYCox5zGnnF1LbZF5ZooY+EvsF1aNP3z68WtC\\\\\\\\\\\\\\\/q0\\\\\\\\\\\\\\\/zptV98k\\\\\\\\\\\\\\\/apHR7REGy7Sf\\\\\\\\\\\\\\\/rdfpp8iQ1tJFWF15JmdLusVPOQPkHhxzOyoFswe\\\\\\\\\\\\\\\/RnGJpbtq6vrFwxvyDqZPJeGZNcyOPbtxMt6glT3gRM1rDKrCCfiwvl35lKlq+\\\\\\\\\\\\\\\/viiJiFl66\\\\\\\\\\\\\\\/erfKq0jxqS0Ri4xIy5EX4oWy3tYlaCpx8qh8AVSLN\\\\\\\\\\\\\\\/VqiMH\\\\\\\\\\\\\\\/UnI21UMRL2rn8oDNMnhp7nI0mnglxWoWdETILaW5tzLZvzDB2qbfOqOOpZMMjF+7Urqf3Cedj8szNTeAEpXjob\\\\\\\\\\\\\\\/1UQEDGDXffk7JiHdBe\\\\\\\\\\\\\\\/ZlYP2jXZvAebhoV7iFW6XI7PYEYe8\\\\\\\\\\\\\\\/4z36E5RmgPrTzdSAovtXIaniTTleqnmNQTctts2kPy\\\\\\\\\\\\\\\/9M5BsCfioPZ3yL64WGvvwwew1NxBqstAHC5JymJxHu8aBlNFCiCI7DcoNzkppZHQXdA5F7\\\\\\\\\\\\\\\/HBKq7FeNONZ4RhTki9pNdFAgAA5m6zRp+auruw1sce7I2kR+2pgoIpZ2SfkP8esUoiUhy0\\\\\\\\\\\\\\\/PW56ndWsmQG6Knq7k8InueErh\\\\\\\\\\\\\\\/8Z0BXKl049YCV6jIGugzC4ksORGPjNd\\\\\\\\\\\\\\\/2IRUnFdcesUFPJr4oRhNJBALqAilxv6AsOQfndu7R4cnC0A\\\\\\\\\\\\\\\/B9pMmtTvXI5ja+hXdJ7bzCUSt9OOAkA3yU2e5MXcPm4ooUN\\\\\\\\\\\\\\\/8RTe0nli+yecI59B+Jw0+uH8xhyWDZtdYviFNeyI6i0LOU7s0zV+j++RbMRxDxKsfSuuoRbQyy+tdDpnw8jHLr7S8TmWtciWaW9TjH4zCP23iwVeYFyd1DVTgstQFgshVR7ex1kFvfB\\\\\\\\\\\\\\\/kV6XeNSu9iRCiuFWWB6ZNgvNVyD0hYn6p+0mLmP04IYxsNj+W6pkoi9I28f6Mmvw3j+8Ft4fTnlCh01NBU1nG0NFZngMkVbwNgONclJCazk+2vHhX9yxZbW6cy6bQWwUQfgcVbdx5fPVNf2UQZWL+QljYl0oHOikqDExjJganKH5cwIOLZJs9oqGybHvhz3kYtgvqeZm7ZlSwNp1eIy8sdNRK2pGfAa0hsS\\\\\\\\\\\\\\\/IklwdIZUCQMh99JP4qt78\\\\\\\\\\\\\\\/QymVA3H+ucyXQM8lLOn6dEY+kaFDMiFSlustdqoFB5mwBfu8HL7uy2FLBGSIkTff4etgqKyCMCsiYBjeZBbtcuCoowIrxfZQ2BogYucpf3vkz9Nf2XG\\\\\\\\\\\\\\\/SWIUx8hAJuUsCXG6ancrOU+DaAT75Kk+Pil\\\\\\\\\\\\\\\/9Dx2Am0+bbyOPdSRHv9LJkWdcN+PvmEuSqpEC9ygmmAyHYABok5fkC0FHGmVMzu8HV\\\\\\\\\\\\\\\/XQ0NOFdUMK4bdNQuIDGLCtKp5XEx5syg1iueyJmhUFLfq4EJj6aj5hEgsthqRJ+LZMl4Xqlzu7Nxi\\\\\\\\\\\\\\\/sJAu6wD8E1zkxI2NgGgERrW3jprl64wv31cMknv\\\\\\\\\\\\\\\/NEaoxMwmQW3syMG6Hm\\\\\\\\\\\\\\\/0sGwjDkZwJw8v6KjtktqcJDBoKIYu0A80xi4ixB2aRGhlcpeLMnKuO1zefQyGnkAsfbC5ocR24GBgelLkBRl5fpjQr+051cqnB7Cff4uwDYHWzG4zYgmKA9voy03GFqs7JNC36OR\\\\\\\\\\\\\\\/TcoOcn2ti2x7mkLkdEKPTUdQSB8EqVzDDxHunWeNUcEhqDlvGbiv8IxYok887Wt2h+07mKXG\\\\\\\\\\\\\\\/M9tNWJblH61lDHwOgjlaadraX904wMDd4cYDZZwZDULzJ1wt\\\\\\\\\\\\\\\/t7m\\\\\\\\\\\\\\\/rxNQEBzu7LANGfwosdvaScg8+GFPjNBLylPcsF2LiepVFoUTznf+ddzwrNI19nuLhOhLLUfjBHOs1L2dDnAAx14PJLWb\\\\\\\\\\\\\\\/7Pz4i6UU6IcjzR44tM0QFSrWqLAPT4RD9sBQOrOk8kHFXO9SyCNqjEc+tj0ZI7\\\\\\\\\\\\\\\/2jO2mZ9yXddwOziYwr\\\\\\\\\\\\\\\/Af1lQqWwba3hopXpifCHWijeD8Xs6EdwlomUjbJ6\\\\\\\\\\\\\\\/RZ+STOs3fyXKr9cfkJxtq3cm\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/BohCRZe6ANhg6JthyeQ6SFSEY58AtCajinnj9yIXLJLyiUTHPB76TYHy1mZFh1ow6UXJ8EqjwfBPu+bqdKZhGQX17ObY6yDEJN1Y+7uYHeVlEenQaIL6qcr6Ofdl\\\\\\\\\\\\\\\/PHbuBW9EDIojIRn8g=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022tD05qSWv3a2ZALU40m6x5w==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022a6bffe3705cb20a9f304c202fab9902aca1311f8f9a827fb01b15d2d89379692\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/5\\\/1\\\/32.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/5\\\/1\\\/32.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-017-0234-5\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-017-0234-5\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-017-0234-5\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}