{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022ySyfxgBZ9ITwrsM+2bKxk4LEL33qzvTnLsmfa1os4OV38owo+gxi5QxsnAulZhrtHsLnoa09+o+38rP5n4Bk3rNlQXIN04wBDBFkY3nVsO3faM3LyE\\\\\\\\\\\\\\\/CtyaFLvlfcElNd+xYyLJLUgsaWOQPpqteFfSxAF64CYU\\\\\\\\\\\\\\\/g3\\\\\\\\\\\\\\\/zC6OpLFJ42irYPLzqKukazSV0x3aBj2vP34w2jbIU3eETKt7Jlu3eVVGp\\\\\\\\\\\\\\\/AQzoGHP9YoUeX3I1Tcfcc5kE5L5Q6lpfxeRsDf8w+W90Vo664XNTG6p48BjsR5qVGEOfwLazF3X64pHAIl8B+FF5mt4LD8jZ21ahEVRPTmPxy0HJ9e\\\\\\\\\\\\\\\/mcU+vUaGovSTKwfkPRMNFuvXCupnkro+S5eHxap05odcAmB8pU1k9\\\\\\\\\\\\\\\/jH9L26xxb5nq0UzpUT0TRo2TOxCLSTnrX\\\\\\\\\\\\\\\/9ox5MRyt4uUeiQDyy0lyTv+S7+kx+Zez\\\\\\\\\\\\\\\/tBl\\\\\\\\\\\\\\\/FrRWg0AzDlbdR5P0kDdwGwEMD15osh3uyaGt561kran11Q6wJ5wqudRSihbvJzBANWvKQnY3pajDSYJzHv+0zCP74+EwViSWNB\\\\\\\\\\\\\\\/yQt5ksH\\\\\\\\\\\\\\\/SVN3bIjI9DtqVDZjkZqb5F6Q2fWeKlC1LeCfoVVUMwsKJopMeOEmLs9dM\\\\\\\\\\\\\\\/5GgraHoDu7c7ERmai26j9zZjv+55MKmTNJs73KBLxf6qPhzNN39enKbxYtGPfCghR4toeb1IM3oClhhxd7+6SlBfxFqs9591V7SpGeO7lhMYEhayHJTtepq\\\\\\\\\\\\\\\/xNnx6KCBVcmcmbJ1XLhrh7UEc2mdrfbc3SqORI\\\\\\\\\\\\\\\/DSgAo4EX9I6+G9nROd+Zmk5U5FXqzNDmeLX9EWG4ZvkOrvIyCA\\\\\\\\\\\\\\\/eVkvdQuXp9hpG9bnHngIrZ\\\\\\\\\\\\\\\/FGcVAQ0zU5nst44hbOcy82PQcTG+t57ncMfDespDu2ffppaLN6J+pxDXeqk8wobHdYOieEw4bRYpaY4C\\\\\\\\\\\\\\\/aeDE7yVNdGD7prDFw9H9fw\\\\\\\\\\\\\\\/JOfipchA6P67XPfENoxvaYJvC+6IWchrCX7xhZK6nTCqFiTqG7w8EmJtStidvxpF4i94gkUezh5k+u4F1Vtp3zbuqB6BHfw\\\\\\\\\\\\\\\/L2ppGKxmlDIU5vkw4Kqytqd6ZSXbXCnYd85AT0ta5xkYPfHx+8Qam4JbikglB2rUChpUm1kL3J\\\\\\\\\\\\\\\/F9nDd6iX8nkuQRasNp3qNPByWNVcYQ1poLje5Lm3ZL3eqDKJFuQG2Bm8zVGN7PmZ1nY8rZUyxhz5EQnTPD\\\\\\\\\\\\\\\/gigEKNTWqfwOoFajOOPLjz0MsoJLALnRcxkCQEjCK5mS0MeTebq0gmDpvQVxtESxZFfOJUI+AvCHR5nLEcr\\\\\\\\\\\\\\\/f563dt\\\\\\\\\\\\\\\/De\\\\\\\\\\\\\\\/uNNJSnVCKHHpYgfxgHTD2BAnhVGq+\\\\\\\\\\\\\\\/pXQkiNWFobTZpFqnkStN3z0DEbuXysIG\\\\\\\\\\\\\\\/g20OzO8WvcNjT3goAbJSFJ6fWhRiFfg1dQ5\\\\\\\\\\\\\\\/4T24MNGzr7HYxviPTf2dqQeggkLQNsrb5JYe8TV5Rkbs4b2bN2V+KqD7cTNlvh+i+gnLIwmbIjtNe5IB\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/wEpI3AASnCjcEOlXHMBPsO8WSch3MyYMOZExOSgZ3DYXdD1bOzLAdMzCNUoEtVPMFg03CN8FTfYwbA85j2hiIe4yXODBkdk7sCdpqqSawGqXeWv56hUu4T+xfkvVenep2TnWIOMD\\\\\\\\\\\\\\\/Kb\\\\\\\\\\\\\\\/F0SN2FswJtjxklZ3GMd+vlCZfu+eOMUmfKt9ZL0StPjHfZZd4PqEECZTyoLDn966o9h5vVW6Xf0GzDJT7oPMPdNOhbvd\\\\\\\\\\\\\\\/IJA6gFIsHqMlqQpjH5Xe9VTDalwoE\\\\\\\\\\\\\\\/0R+ut\\\\\\\\\\\\\\\/NutTVqP\\\\\\\\\\\\\\\/KMi8RLs3RKIaNkCCmxYGy1tbRvDeZG2i6D8SPjmX6\\\\\\\\\\\\\\\/9klHYJ5uG4mwMPh+v6KGHgkjMqFblEnDT\\\\\\\\\\\\\\\/9NpJo3n8TyUsB6u8bV0bOijfGdd0o54gQyO9YZQPUZ1OavKQNqpJp3AucOSaRYXKu9\\\\\\\\\\\\\\\/HvvCBQ4qTdvf9GaAWgrHv7g1OPnUk5Cf40az72qQsmp81FzrmkaXDXpMgZneAzl4S2KjPxE1MKPJFj1HnjzvOqAhhHJW0wIhxaBAmxsGcTUwlAxElwpS9DzWCmtcXMrn7HmrFSJn4RWbZ+pAlW3LycLaJEXqZiGSd\\\\\\\\\\\\\\\/9UAU2A55UnyeijDviLG8Dg88C0PnHejOvEEEi04AQPjwogKx3MdkATkAOCFprtaX6SApE8xsDknsj2RLfyceXr4qhyRENQeeEyGOhUIdwbPM27EbiuhiIv84b6Z9KrjU7DhxkZooIq5IjY4Q1AvXIxBqnuxyq48GS\\\\\\\\\\\\\\\/Ylmg3OikTcocoMkETgV4TnOowwITc7LQFBjR2RjoEUf3rVX2ZbHeYq70Gvr5a4CfdmHdCuZxQ9rl4scH2n+2Q5WggTO0tk7v9GzfT+ND7ybv89uPpUQafD3lPxvpkGiYl1fFwPzlPAGvlv+AqEG2miyhXQ+EiC8GNHDo1dNYyQEPD2YUT8ldyxqvn95Lm0u+qSoqauBmQQO217A\\\\\\\\\\\\\\\/gpjR5RC0PbchtVE75nCLMP1trNQRLjF5LummQSQgKqsCozvxIz2hxfqtGR5mIkIe3BxvkooJY9heIBzsXJWzxDUJsFhbVzG8pPqWxXKbXwjbwH1CFZiXFZuroSYlRVZlI9zrvVWRYX0oB6ZufoBNf4TWlL0xSdQ=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022OoBEkVptELrJhGmplFvaQA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002219da9388ffbc3c5456c3496b9525a403acf6ed85291261f72e467fb7dfe2fa57\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/75.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/75.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-016-0183-4\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-016-0183-4\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-016-0183-4\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}