{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022HwK9CLWtJU4UfpM0VFcEIowXkqmhPj6XlQirA0fWC8\\\\\\\\\\\\\\\/rT1Sm90EjKiiYxtyXXEixE4cvwswbOtpxyWjheHRgg0PBx3gfJKrHVZ32SWlgnUQjUUybud66unbfumUbxbHIyYTtSzjA78a\\\\\\\\\\\\\\\/kbJe5baTF0NhkcPuf2wkcK0DISbDs5dfruluElMKbOywcR\\\\\\\\\\\\\\\/ecy92sUnbxt3\\\\\\\\\\\\\\\/8mbTvpaK5LM67b\\\\\\\\\\\\\\\/ibBwXgBdbs15\\\\\\\\\\\\\\\/iy77C\\\\\\\\\\\\\\\/Dx1WKI5iMmSw\\\\\\\\\\\\\\\/nkOxdhnL779Zq3kQCThPxfJXOR+Bc+S6pmEg0BFsXbw3tf65HJ+69\\\\\\\\\\\\\\\/OIZtpOG1zqqGx5x5OMqFjqWS2N8uLmHiHD8P\\\\\\\\\\\\\\\/4JSGDbb\\\\\\\\\\\\\\\/viHmgyUQuk1mrXuDhpzXuL+1W87TzpBtO0Ntt9bjRfzzASaOOOkxZ8j437CXnd+H33n6L6+AlBOPo4pwhKHjt8Lk5urN6XG2jMoi8k6G7PZe9JAhzKIT0xQY1MipjQ708VymgcMqsIr+JA7WDUIt7ojLcT9eaS1PWFPpyAEGwjcsq1uxN\\\\\\\\\\\\\\\/6VBmC3tWQbbvEool3pLbxyunmgqGAIwQ6ghqGC92mc2FlAcc9GTwsn2DXV1cn+y32JW927EQzuUCohPZKfjyxaCyHIaJrrGiRXZzM\\\\\\\\\\\\\\\/s6CEqfe\\\\\\\\\\\\\\\/vJb0KPPtaLiFbHkn\\\\\\\\\\\\\\\/5qn0wVr9Bepl+Nt1DvyzIJeksRtPnGnfcuvl9IKIVonedypOWhUYe0RFIWUWBoZcjsT\\\\\\\\\\\\\\\/wWutvqU4oDBzCuOdsCvvgIJPkktExmzDZ1M0t7LNJLp8ynyePq9fBe56dhSmqcylz523bUIxvR2RmjMkVfW204MbkWlfhqImIPhRozC\\\\\\\\\\\\\\\/Szdy98fjBg3FNBnmFhCbhc5nDPtiMH4GO0870Xk3m8OR07coU9mRjtnFEku6nkcJJkFMkKoe+uVe0TtZfW6C\\\\\\\\\\\\\\\/F2V8iJuGXQuI0Du6W+M5oQaNIgXN8p5bJjem7ZjNVYdtLn1uoKmmSHYZRI7q3jZEhDpd2b4tRuGiYVyQEIUvHOd2YEOlu1G39Kc207YT18LCo159qjB7n3Q+wtp1MexqrqUSQc99R4PPLm7ZRUgmHo6lJxM\\\\\\\\\\\\\\\/IK3809iO+qth1pzPrJu++dh\\\\\\\\\\\\\\\/ezy6m6T\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/IR8sRuRLE1xxCf2xV4pDJtmDZI\\\\\\\\\\\\\\\/PhZgGGQFSq8XQny6+Y51W+GznY4ictopjF+hg8gjXW0vC\\\\\\\\\\\\\\\/xlRacEs9hLFCT2z57gL780YvbbbqQkow+H\\\\\\\\\\\\\\\/ZM79Ik+VmGFjg1iZeH1cNOc7YYm3aUDHMqs8wDl+ACSFED9MDHatM0MAd+tOeZzCUi9Nf9l+nzkZ8a1vo2njjngUJxCfoxwR8cJ5Qnp6S5bM7otcJRrIN66nEqafYNTBgSiTO1KSLq0MZt48sObx\\\\\\\\\\\\\\\/Y0rti6A98jAfsQCrV7Kdjr4AMNml1SlSWFAB3M8tHcTPY7ef04quJbDXlSrmJd8srVFtkCImk09kI3+NqFha+JYhOjSLXaWduZYpTG9HvlIaiboT+iZBTAcjr+EKadP17oOEAI6yGqfZ\\\\\\\\\\\\\\\/4bazhshfZwJtowstncT\\\\\\\\\\\\\\\/Errt3EuGf4u6mehnkQRLFdzUUlU44HMQ4KR8GwnDmYQER0RGBb2V4\\\\\\\\\\\\\\\/oKvZXDxZa59CzoSZVIb26\\\\\\\\\\\\\\\/Dkzu\\\\\\\\\\\\\\\/0QACykZoxTuePqTAvhh8cajxaKK1+ManQrC1NxI\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/hzAc8XU8lPFhk97\\\\\\\\\\\\\\\/bSR9MSlikjrQ4b0oOCiZzX9dwWgJq+nTeYu5r6sGfaYapsElY3Zw2BrUdOy3hYNRKh5qiTnx69KsllY96RqvtuF\\\\\\\\\\\\\\\/uSN8YQZBqXKx0ErMXjUnz0DD3uatjHInQRLP+vPMb16smHtWgAbi06m1AsIlhmUUZiFDaD+w0aEl8ZCgDilmLHL\\\\\\\\\\\\\\\/oAacliQ7PxdV3eRnCrsOTMOaA2jwthCqhaOgh\\\\\\\\\\\\\\\/dysoZs+l0kyvylPlb5+wBLiZ6Zmdm\\\\\\\\\\\\\\\/3ZpUD4gzvrjbBKnwMF5HzdOIH0xJ1pBLw5cvRy4G8yx605EQ0tkC6uG9eBNc6zNIzBoXnD\\\\\\\\\\\\\\\/1hRZ8RpUeUg24CP+SQ6FsLV8NnNUQRxECTtzGp2MiXNRGmPgXqj22N0oWytiDwUJuWfj8QRLvxiGCKr5xfbUtfAEBLHR3FtnMGZL7ZHPLQILth02iB2HxTPNaXedC9dPV0n\\\\\\\\\\\\\\\/haJS\\\\\\\\\\\\\\\/bLbl4vZNhW\\\\\\\\\\\\\\\/qHGNFRVWjs+BdNJ4H1tT95WtMByoQfboa0goR\\\\\\\\\\\\\\\/zaVRtQa1jhRTacEIQ\\\\\\\\\\\\\\\/rpWnhYq44hv4UaOvpJPGfccyORxlQSo757\\\\\\\\\\\\\\\/mZPQZWawJJwAwGi9UAqpf9hunhKCg64RLhDFQcvsB4blW0f\\\\\\\\\\\\\\\/+8sgF162gV3uM5pXj5TWr5wHXpVsYgXb5utGkp2xyVmALlPcbsSRgKiqXW8bkDyvVSfa9GVgDTrQ8tf+q+SjHKUlP34SsiFHcblucV+kFTiIQET+iGrPJvqlNDpcg3NdLSMekIb3FqYne5suK7ut2HUTwvsEle0CkrHEX+P\\\\\\\\\\\\\\\/6WBIx5unHaV65j4R+nkuPnXh0ci+KxpYNBn4niJK8THTgpYx8YxuHPmRFt4DFfTHl2Ao6sLXAi538xRUh0vWBtS5QRB7HVh5yjwC58jndqBxR\\\\\\\\\\\\\\\/Pi4QkZ+yzXpDLACIEdJVXMamy0\\\\\\\\\\\\\\\/yyO\\\\\\\\\\\\\\\/Ge8un7rG0L1YKEGvAVssmbYvf9StY3IjjZh6T5k=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022Erotw5XqMXSfWg1Sx4vEJg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002266ac3afc1044e108665a5c248951ff6fa6a7e1819c7e3021bd4a2bebc570b50d\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/88.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/88.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-016-0195-0\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-016-0195-0\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-016-0195-0\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}