{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022rZPwwU8K3fRqgbA83eMZhSGeUvaUXOi0IEc3ImEW1t41IJl+AgIhi2ZGcOD1LDCGb1qWNlkB7A44Qgi49\\\\\\\\\\\\\\\/yxpBZIggm5jfugNcOp0a1CgoXHVJkYhV12IEmFRo0qyQ689jpfP8aoM12tib6MEStzkWP8NZFWgP1c6Y1UYk1p\\\\\\\\\\\\\\\/NTdS4Eb1ZSgZm6U3lJFQVrCZKK3XJ9h75jYg3wwGf1WHVGQDoAwhKNx3Z4CbLWqAFSH2he491zJ8B+7BMie8TWnyuAVvltju0YyXhu4Vy1Kbh3nspCi1Re0j+od5w3KhkCP82UJHHnjvbT4yxcvlmc4UnchC6lAFTtUBBIEYoJrjpPfOuWdw6nxin\\\\\\\\\\\\\\\/EYaZhhf40NixPbr1viAU5Qp9UStLdu5pRkZlauJHLgR5KRHHp2l50ktZGtkS\\\\\\\\\\\\\\\/OJ5FtFAQPY92XOoGeHS+Vq6SpmCzMkxefa4Dvmikm6hoLZIzm2CHRELRxPHTBgZs\\\\\\\\\\\\\\\/Fv9q7alBRQYN6oVmf+jsgOMRuDS1zgdMsx3fG9EX+ZVULoK9gkgRIx51HutOHP6\\\\\\\\\\\\\\\/xkg8LVl0dRly5\\\\\\\\\\\\\\\/j2GNRKGTUcG+OttNokbzuZPMbNueDKvSCDzalLGhItb1gizf3rtbHin1lTufFdn2uwVT3Dh7N6wx9FtAwoTcCt8orel7mnhX3t1JmMwIdZS82329k9Iyk7Ujb0zkGTkfAm2Nq0nW8z0DOtltpLh\\\\\\\\\\\\\\\/xySaf7uGbq2y5L6+YW55XI2IDroCJg1qXYGi5duKBiSHS3863mMZcA00RYXcs9kV\\\\\\\\\\\\\\\/fbYFfZN0JBpqL8iAmQO7M3YiRxyx9IdkUTaMJ1pgs+XcstH\\\\\\\\\\\\\\\/krDelCrl6KDrHC\\\\\\\\\\\\\\\/b7BOjau7nC5B4IHWis52DaKGsVuepqVKCc8l\\\\\\\\\\\\\\\/oqQ6cvv\\\\\\\\\\\\\\\/92lCt+g\\\\\\\\\\\\\\\/+PDkmvGOGbCB7U+H\\\\\\\\\\\\\\\/TTyjb4+y3MVvl+5iENqmfs8GfAeP\\\\\\\\\\\\\\\/CAN53qgzsmKXRqrnyX3p6nOhzMdoiG7u1Os85dtMHkdgPMx6kAMJ\\\\\\\\\\\\\\\/ZQW3iQ1ZcKlLFpXpOZivESAd3ZksQ+z\\\\\\\\\\\\\\\/5mvdYNVTAGV2\\\\\\\\\\\\\\\/RU3TosqHiWQFjAMIHxqHHMnOX93KqBjPc9lNCk+cL6s05vg4+VOUU2aw9fRv0ZdpRniYfj3A1Lo2zCrFHmHIgDFEREWUm49qHfXCbtYfbuIMQ00ZvC1lu1MRbMAlt0Y3x6AiP3JZhwiwvyau6RjEaIAvMyxb1xRGLxVXXs3HzuGhAk6y8pxtmyxjMVUUEVd7EGLQB+wJSE68Osmb6n5bqufH1uoi9M95Ii+2vDMAz2zZonbC\\\\\\\\\\\\\\\/RVYKR86RD8aFom6h6fjI1QMzxMpZTkFKheVE7YgY5lxefSo+gux1kDuXRypFxQwVEwihiBpzu\\\\\\\\\\\\\\\/tWl47XtZtwY7U\\\\\\\\\\\\\\\/cISSQ+fEJYNasLZo1XkJRxMXqUUP1nmNTcDwkzFrN8uJN3jGTUPa4f1nr\\\\\\\\\\\\\\\/5mYmhM3cY\\\\\\\\\\\\\\\/+G7EbM+GYALboOJiLfV4Muf342SXz3a09EAjBr5mRTITdiT2xAy8K7iC2MRNmk\\\\\\\\\\\\\\\/D6ZBdjJmaGgE\\\\\\\\\\\\\\\/GVx9mrj\\\\\\\\\\\\\\\/VK9dW1UL1drxwHTVM9kUxchNImUeSQXXvLt3idOOReo+rmy32DD2keYOMVTKsfToVcbhBE80gZ0gUcQHKDyHFVODHP21Pw9VlB1P6q9\\\\\\\\\\\\\\\/ao9fvGpc1MZyIvsTS\\\\\\\\\\\\\\\/3vWGl56oBDfw5DZhccTNtu30QzocIrJAmNc+ywAHTtnY2Ra93X53MjUOwzw3U1ucDXpREtGgzu2RnuirtcFxeXSWw0IvCC9hVWd6T9U3n6\\\\\\\\\\\\\\\/orGCsMj2rGUBgQTO61fHQJjaihhh\\\\\\\\\\\\\\\/pfQjyIBZ4Q+rRz7SuFuSo6EdTjpMOJKpQPlf\\\\\\\\\\\\\\\/gwjaBQJUYzOFYW1BkfW++usKwElH4bBt8FfAU\\\\\\\\\\\\\\\/MnzrQwn7gbZz4I7JVcgOQb2SE8cUzTHmzgnAhw1X9iP0616rlrMCR7hE4fl\\\\\\\\\\\\\\\/iuq3kHOXqwu4akWhobDMfUSzgJPBt\\\\\\\\\\\\\\\/7wwyADEeMYfpCFtrN2yXh4iogBli2ZX4kWEdkI1ORzMYiEfH9xcOUosIpxUyYGS\\\\\\\\\\\\\\\/W3yBbZFqjQaXo0P\\\\\\\\\\\\\\\/ADPhFCxI\\\\\\\\\\\\\\\/Ezizp9FxXSItVOpdqzLVuNSSBeXU24UjjL4VVd18L7rCAMqLGYecx72\\\\\\\\\\\\\\\/QIZEbDmXpUXJZmq0pL+6T2HCxYmW+BVXta4QnFYMSf+ZLWsbQaiorsWua0NxW4HwTmJJTvV8icgTFzFRdXke8SKdHl61l18WJV1ewgeoQ41AhFJGuEGNF8TZBMcfDQ7Ha\\\\\\\\\\\\\\\/5mqtCkb5C20vpwTuuSkKwX9IMGge39Ea9reuwbPEfI4xJ+7blkMpvK4LINtQTq5CeF8vc\\\\\\\\\\\\\\\/ptKMaReizhM6U8N7D+5VZKkOCpNbTaOLOzl1aMmK\\\\\\\\\\\\\\\/cLYNVPQvvj9IK7II9CbMtiCXEqaLG5PDjgOdgtYvU4ztsaEUj4yuBSCr\\\\\\\\\\\\\\\/BnckKWeA1LNRJjqxNFyT\\\\\\\\\\\\\\\/5c\\\\\\\\\\\\\\\/VgBW2+EDrSk6U0BJsFWcOyH3svTuR73vCSo4KvgATeDSItC00+IKhXnCPNF9BHEYUHCF\\\\\\\\\\\\\\\/rNG+JRc4DuIPD7yT0uJ7RURohSI+wEMoXHUVmX8Uts98Dtl9cUIonFTlUWDVVpxpO5XrqK6Tq0UAlXfIfatoNTEok\\\\\\\\\\\\\\\/3RhrHgRxfAHAPwhMT1bECvHYckJIw5xKfFPh\\\\\\\\\\\\\\\/jGjY=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022twur831B3g+Sdktrpjx1lg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022df9ce07695708b0f08f4f40b63dfd6404376438feff21a50d6b7eaa034246ed7\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/61.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/61.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-016-0164-7\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-016-0164-7\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-016-0164-7\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}