{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022BmCLkCLwppaZ6oIzuQXtwju2SGcgwiVNdISf6gAE\\\\\\\\\\\\\\\/KBnhbzbAgnKGIxYFt6px274GJ7EXJE\\\\\\\\\\\\\\\/VehhXodyvEVEoFqZrDn0asNP8KtOTE+p1Mb885OVvMb1UCWPlVK0thCnsVh6+LBRLxxkZBJenIp74wJ1CGTB\\\\\\\\\\\\\\\/RoJhA3pj+\\\\\\\\\\\\\\\/1FSYmLpnL44TxYO+nsgBdAXZcL9+FjN67bQrWwDxb6HYw0zTvsnKknA0xyCnj2lIAtMiIOsO4GkhlaUUomXIc+oM\\\\\\\\\\\\\\\/QJ9uVjLdUrYF6e4HPQBWSBAGk\\\\\\\\\\\\\\\/eIAa90fw01zOEErXkPfowFi1yVeOceX6aMsFuqwv4YOaQin90L4lVA5IRDJum+UBPYADRgJgiKIW8dlpukKtCUHL\\\\\\\\\\\\\\\/yke9rnC6jdDl8tREqzlnBgaLaqK7Nq8NcD6ulxBBDzAomxbS6vkFo6hv20JB2c87TBs5KLAZ1bLNU8th67W7aqhlN59mI5MmawRPJHr2lOUvImeYzC6pZdGKxFcjVwGS2OyM+aBnxhwTTdvZwNWsY2Pt6\\\\\\\\\\\\\\\/k4ZoTP9HEn\\\\\\\\\\\\\\\/BNt1WAQN4wQpjQZqe4\\\\\\\\\\\\\\\/YFUw6JRuX1atb7mnRtjGJK7RW0rN2OCAKwjmO7jkNmNibGFn\\\\\\\\\\\\\\\/bXbPbUVdtjgLdJdMZ+beAQ1HBrZE8tkBnVNQJ749g\\\\\\\\\\\\\\\/AUI\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/5EEIRnQtVF1NRoFIXeEGhjXkXJ8JDvN\\\\\\\\\\\\\\\/nQ0Jhggb97WhZpzAqOTwniIlaxkkxd3fgs0ShikJh0as+fal6ReF2c804ha5qR3CBQQx4Rvw+P43jriDedlWVkkZ5pD8ilV3dmDQGgokDR8LYRpW14LM\\\\\\\\\\\\\\\/D6odghzoc89M3J+rkOaCKNZXXkXGM+AfEXJsLD3kR84mdvvVZOScUYhsW2tzDnbpIBIOE3tTInAIEAfqX9hdHnS7\\\\\\\\\\\\\\\/uoPvB4mg0T2SFD5nvsyPdgTC+hilts0UeqWhkJtnZ0u8Og5IR6pIqEWgtGwT3OZMznmQkuBSX1x3BvIz0To17+DsURofkuJBK45RWAmJzblblHSdgYPyLQdAh3Bf8uMDwhhzkAW5ari+zI\\\\\\\\\\\\\\\/hAkXonD2w378GSwh+e1B0xxuPVYVeTY\\\\\\\\\\\\\\\/JL7wN+oXTwq0fTbHQIHPSgVPCqEBf1RBdeboL\\\\\\\\\\\\\\\/6mxuNhK81pncHDOatg3+Z\\\\\\\\\\\\\\\/AzEvt+JcAWqWy2PwwTE3f1CxHQgeQel8IzrRKSubS7OgaBC1FBFjLaGsV32tJHaahcHVsByh8hOz9HOOp0538ENyA8fmDyQQLR8\\\\\\\\\\\\\\\/FDbVnvYskM54lcLGsUAxMWbMIRyZkV1+HvU+Zxjc05vagLBjg\\\\\\\\\\\\\\\/JgmKBJxUsKtMbCP0QMljZQcug6\\\\\\\\\\\\\\\/tompIvDynlpqJjQQfZtySKLo\\\\\\\\\\\\\\\/gQHyFvJqCo9kSvPAsY7KGBLvlF1ybKTpVNVxqnGo1rH7P0hv626Ft1AnHYE0Hg4rYkZ2t0L4G8b9pFh4HUj9npueHkZgUOc3OQzt9giP7Zv4kPc0z\\\\\\\\\\\\\\\/SdLBxJnTaliY8E0t1TOjYqpoSIqZvfp2J6w08BUxc41BYARWE8q731aYqTD4M6ppsxZqDoPBvVyoG0RZudClqqjd\\\\\\\\\\\\\\\/8dMZSJM4kBt1jwkRoykBTddrus302aPjhDCOBZfo62pgu59JK\\\\\\\\\\\\\\\/wAsaoVdJIH+JpJXZYYEDjXt9hxN8\\\\\\\\\\\\\\\/Cq3udeR7T\\\\\\\\\\\\\\\/Feqt7pE3BwT3IHTChU5fzFpKY7k\\\\\\\\\\\\\\\/IYy1Tvdo4pKDhwr1LMZcfhl7Vaq83VJ7NZw24wCg3nHzQAeKueVJ+yWrAxPq63rWKc4ZgX2w6AJdgdMY40ODfZOeq\\\\\\\\\\\\\\\/1movgwGA7f0h9FKwHcv4eKk4GVBqtdy\\\\\\\\\\\\\\\/YaaaW\\\\\\\\\\\\\\\/jWJttiAJmjIWXuGvRlO5oWMV+KXt93rQecYk9ZsytN5Vz9LJxpLqXW2\\\\\\\\\\\\\\\/zJCQrubzRhL15Nw1v9lKMw2gBcHDdMBKq+B2Y6omIs2o5No9lcednRDnU2owDyLroBiXQguG46yHEpQKGiEk+jcGMv+Z4XreKttQmszWMkfDcxAUBdYiWSVceL72zrIRAgsa7huG\\\\\\\\\\\\\\\/zy6Yz8RpCTIC3ppJJ+JggJNiIL3L2raE7l7heXzyQeRFLjh23Gifeu3YTThbHr9AboS6TdelmUDqffv13rU3ThHN6TxJ9M60atkB5eWdScU0HWQ4kWYNJp3fcODruV7Z1kUN\\\\\\\\\\\\\\\/JZzxa4QGlT3Z7CJE43rLM0gEggPYwjkwRNR3ENsb2IM6pfm3pEJs76n3i4w4Z+jNXvdcflGc8HtTlwbD3SuvyKndeA\\\\\\\\\\\\\\\/BGt22coXK\\\\\\\\\\\\\\\/UJ5WaqsGil1ZpGIXRRJRd3BmnyZHXZlQhFQ10yup+X9aro\\\\\\\\\\\\\\\/TmAjYTv1jLBfCnvKLnIaXR0ZLXXtQsjCpWuyr\\\\\\\\\\\\\\\/FbOpAqHeKG6jzVd10oVobiu7q29PJAVE7a805AOTULcY+sEyxQnZsUXomFAkQpPS+JoiaFdWFuL7JcEf5nl9LU\\\\\\\\\\\\\\\/EWifi35xILYfyvppDuk0Kq1p\\\\\\\\\\\\\\\/6ZLcDvL7uHHUNnfoDVHL8xTdbzKWjFkOrHZ\\\\\\\\\\\\\\\/xopVOjq88AXuKfLefdNHGeWvcKaPC4mvH57qW0ZhpyDfBwxKvtqAX9oo5FHdNZ3tkb3kpUXpiRdgiKL1+tWRelhCrl6dS8MF5dWu3D6N84d2YLD39q7FRtmQwN\\\\\\\\\\\\\\\/a\\\\\\\\\\\\\\\/EwXa7hFcLIWUOJOXMCL3J9tfv\\\\\\\\\\\\\\\/jrcjPoV3i+h2Ssvkbs=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022yHMS5UvZhpwD+p2EOnQ94w==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002266ee97a492c4b4325c2ba0772ae7ad6a946c6f183201599883010b0f3efa1314\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/5\\\/1\\\/34.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/5\\\/1\\\/34.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-017-0236-3\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-017-0236-3\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-017-0236-3\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}