{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022oZeF2+t5JLyEqAJwRbqnNazIoVghWBZ3QMOYRF7zgpi\\\\\\\\\\\\\\\/IM3MchU57uzrUyxWUSnKUihGKRVkw5G5zOyU\\\\\\\\\\\\\\\/lDQCae+TUpKn0NlNzme7tlpmkdO7whZDC669r4p\\\\\\\\\\\\\\\/ZrzcxTPmA3jY1aaBkgSLFwJrSt5D1elwkMsdhniXpmABTaAjZ965QTPm36COWrele78hVhqKvu5jsu50BuoSsF6XOd2ussfBZ0t5Md5XQuBgeBxsa7TCJQaegUXPvkX0c5jXYGhYQNJvAsyQRurg9H5IAwgWq5kSmj3AY01\\\\\\\\\\\\\\\/ePU69Kv7S76icmoiP22mG5WWpcWMR976T\\\\\\\\\\\\\\\/flGWeUv6VMW+aitum27yc3tXerW0FTRjZGA53wUU+z8NZWEzPb+BpYX9Y1rau\\\\\\\\\\\\\\\/3ugt6nylRV8qejOJ5Os6UXIijYumOQOk3BjHbYFlsGdgYG2bJ8t4Bo8VBLAf0yWF\\\\\\\\\\\\\\\/Ek8IlL4VFS4zAQo29gQ52FC2ioAYiRjAA4m+RvfIkEzrVGK2+8fmhzxSLofggOzLLyQMFukVMaHsS2XV7TyhaFUlFdnHAVTZLpxQPjpbI3NG649paaxSWkaK6h3hctLu3RMQ3JdglIDhcQtiCqYs\\\\\\\\\\\\\\\/N\\\\\\\\\\\\\\\/ZI50pV3c0MTfKBChq1LWBs6VSAHFu+oEUyTQGjkAGXHbFBMOLDW3aF9CxDP3v4gFr34W5SptGrdtK4teQE27MbngM\\\\\\\\\\\\\\\/KHhJWRmwuQnxA3ycbhMqC\\\\\\\\\\\\\\\/esjepctnz3eiiC6KinUTPCpfM0IexZD4EwVZP2P59eEvAo6lP2JCTZWT49tjm\\\\\\\\\\\\\\\/nd6ePJYsgz3D8wbppRA6cX+SZSeGSnx5QbpdMl7LeMEfFePuxVJGc9V0uJIzf1bS4Mr6Zh4QM9b+4TxPOeE3jDF4H91MRHiMoOp3wbWTDpxmpUCVqSI7gQaHaYIevHKL+ewORBPXNBSo4sNELk90BwXP1Syn7N5hZIe\\\\\\\\\\\\\\\/LpddC4MwLd4JRsZZXO1SlKjqlpnn8LSESbjDnTWroDtrmGk6j1UGAa\\\\\\\\\\\\\\\/kFVeDoF4R\\\\\\\\\\\\\\\/PDBE81vbXCfU5NlDA32JYe68FaeaXGouYz+Kbi2C8e0Iaj2E\\\\\\\\\\\\\\\/7o\\\\\\\\\\\\\\\/4+dfGPDjJDFU5m7aKTldiUbj3zw0Yg2iNKdBhl+GtTJAibMRwVxLskfe5wg82XhzEv81xg67aop+Ih5l6zJAs1H\\\\\\\\\\\\\\\/+O7n6CSPKYwUrvdXMJzJSPp0jVxtlDJHC4BaW2VlWQzl06i65+T1ShBD65q1oMsvQVxzwZXwxOWtBFYZ0PmHj0IItBTY8C48oW4sG+gQpzNzTjLUS9s8ZUvK1iABPVGCAaMWxD074oGGw3DkqK0D3im69QgdhyrSzF+WsiWfbNYsA\\\\\\\\\\\\\\\/RBdtidSGN4Om1EfCwz9RCf5LXiI5VBFH3C4CF9hKJ0\\\\\\\\\\\\\\\/LKf5DGIiN2BJdouhDgpR0weSAqax6r85AV4mPeFfWb2uvGXptQSDwGI0nbEXWhHxqkQbIIRXOGlbxdDI+bseZeIBedUReGKPxgbOL\\\\\\\\\\\\\\\/mg3dXw1Byp6cnyMbeSCVAM2PDdIpa2mJ1\\\\\\\\\\\\\\\/XjNdjkFBCGCf7O6+5DkoPAw7eZsxeW59VQv3dEXEI1i6GbxUmj6zp132n6EPD0fRzKJs3UsCfZzZzWtYU39vuuYLQQlIFHEmtOdMUtbdwhGRjyx2mdnSxkf9nqKWprSLxxnrTjO\\\\\\\\\\\\\\\/XDx6ntl1r1yafNDQajN3RsJ3CbAoVaxEddQYo6GRcz1um0OqI19gUsRxhusX3yLjwHQghkMyl+GqxFyDUsMk6g7UuKOmc0D4kiXDQDH5cUWLgvehff6Ry5Ur77GgFfXgldAGvKHOuqr273AG+G\\\\\\\\\\\\\\\/7Pn2+\\\\\\\\\\\\\\\/ixs6+2AiOKx65AmgJ8pIBzKRsEGwHZXaEah6WjxtdvbMi2LwRuwrnrYbV+7FcVM+vMkH2bJ+dqq84Ev7mMdsEWPluay3hjTJpU0oJNno0dOF+JzORfZ8lKTikgFvL2O8xXh6NNPNO7CVhCpeEnX+kmtfBPRTBL5o\\\\\\\\\\\\\\\/viQIBkFnLuavRYL03tUJ0w0EHygnQRQ2gVD259mY7G\\\\\\\\\\\\\\\/H28jEpWWHnugLqweS1I1LWcBiHXXeSzfzdcT2AAtNSAt5H9A6sZyj3csJCx7HcHhsc71ZxXH9EqLFX1UijQ8xrF7pXh0RbG\\\\\\\\\\\\\\\/lfYesbasioZwzGvmptxYN5QydscWzQpxLGoZgLGViOUPJkw3tfP4yDY6kZwBaZdMTjyKlhmuqmPt+g+tC+e2QOOI5bBFWM6dYNwXwtUh\\\\\\\\\\\\\\\/Eb3PzmbL6Hw7SZ8gledLWew5ZxONQG\\\\\\\\\\\\\\\/YnNxvEYvxFclRNIcqZ29dGushc25K9Gub7wAKnPPFIf4l4Vg\\\\\\\\\\\\\\\/O8cYTQ60nJlQpdUBr2pUAXSAaQr251GhBWBBbLve4oAkD3BXTTtq3w\\\\\\\\\\\\\\\/CT13Byw08EmRhc9\\\\\\\\\\\\\\\/yab\\\\\\\\\\\\\\\/jw6BrdCmvBE1Big2bXqKIYmNQMFYg5eK+4HlNwFwwqmQWtyrkRpFXUOelcGlDSWM9\\\\\\\\\\\\\\\/HeHHo2keS\\\\\\\\\\\\\\\/Wxs+T4N6x\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/GKs6OFhMHY\\\\\\\\\\\\\\\/3WagmXcoTS1EZAkkT0PwnuiimbNaHQczcIq16CvXPmx8BUbjt+cgH2Hi2+GafGQlFhZz5iz3QPhN60hKAZO7n8bLKIuOSY1uOnLUNPCjYwkuP8mtk7dGC\\\\\\\\\\\\\\\/eGUHUdnTv6aNcPI6Pw9cwKFEnbmAZuxkGeIhHMQUw=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022BIrAelSCF6RXYGn3m\\\\\\\\\\\\\\\/ftuQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002279b6602396e834d71d8b9eeb3436cb98f462126ea4f7a966c9e14c13ca31b60a\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/7\\\/e008888.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/7\\\/e008888.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2024-008888\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2024-008888\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2024-008888\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}