{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022fPQdD08JWd9wBZ+Ne9bLQCvPqiaOqnxL3KOB\\\\\\\\\\\\\\\/IDMap+JIKCFdUrM58kRWioZeTlENUbRqTs3T6uPNOvdprwnlHwHtVKlOxoQg3ZPH0wo\\\\\\\\\\\\\\\/hiJJJ8OQ\\\\\\\\\\\\\\\/sWoefs+jSptAEWPYpqSzNz0qORKQuQVonEjwEyhJFNqnFfxQkfSGjCZKL\\\\\\\\\\\\\\\/nlywhIDvvqYTg5DzIrYc4u5eUEb+m2tZpDm4OpPr3ZI50MjZhrOC0ExavfTWk2euf+VlGM+WfuhQ0\\\\\\\\\\\\\\\/hQp5ZQM4a6QYedR\\\\\\\\\\\\\\\/r77TCC67NlCGSvDJjFDSMQSYQfkfZDEXSTrb6SQ9RfB3wvy6oOIJxbmSx9o8HkQj6SInhl6yu4jnkNSaAjUrBdrXA+c\\\\\\\\\\\\\\\/pz916HlhGtSuftKNOQNgHWo5zZxvwVCg0yBw\\\\\\\\\\\\\\\/9foEQeNwaHt7mbhvvR4\\\\\\\\\\\\\\\/GoUq\\\\\\\\\\\\\\\/RBkR8AE53JfnZD4YiCyZ3NOyATDUxO1l5MG1yZWdnXjAFuks403pLafOmm\\\\\\\\\\\\\\\/a858AnD85D2y64L3lulXux\\\\\\\\\\\\\\\/1fepcokKfwwm7CfDSSp+GRt9EKkbSr\\\\\\\\\\\\\\\/7KVR346SP73Wf2evlJRieYwJtrTJ84NH8zIr3A0U2PuFI1OZtB11W8BxvF15HprGreyIvoAR6eP1BnuvyFB8CI9QeYyGi5ajhSxPyqzcxtipBeGvnimn+oMVqR76zjQH3v3YiS81VHxaAXNdmxUzgUzw9hoO0Q9QLrLEwNcsvCk9Jy3A45ss8k4jUeE5UJp3bUix+YJfyBvvQxC\\\\\\\\\\\\\\\/t5fA4mpeGc9vrJla4m2eTW94S4IqkVRHWZlPKWcmQdPCKWzkG4u93vtrkGExmT3wV6JuzF6Ocz0Y52NE4Ltqo2q6zLAOwxbj3fewCGclyzW7\\\\\\\\\\\\\\\/evdRLjmKE9c\\\\\\\\\\\\\\\/gcIaDtKnIc4eNF15XtAy25gK7ksl5hhU99SM8N2poYr\\\\\\\\\\\\\\\/Ik43XWA3JF7khQp+\\\\\\\\\\\\\\\/Cjssi5AgbB1Ym39NT1ehzB83nR3+SsNSBnSIUiaxupRkG78mPecO7bp3EgDPZlxJpIS+UzNO8o8tYnx0KM11SZJFYGFscvKcnbXYAMeaqd+uZ19iPhvJewATyUlSI9zQMGY5gGjDIY0DqVWdLTbTG6JbD5B6dSciLgSwjv1GpZ4rFG1KNVE6R4aY8u7Yv28wBMu+eyjdm\\\\\\\\\\\\\\\/FYSXV8otLhiackpNCVjU85qqS70VTvxPiifH8MCXzxCEF0pOyNLO4ol1VTbRP9UT8EkI9tULaiUAK9KPBI3N7kBQKrH\\\\\\\\\\\\\\\/+84MmecgAJJG7ihpqHoI4xQqBydP1DTujdJxILYptz1iSf2r5uzIWrHikDvCA\\\\\\\\\\\\\\\/TlTJFMaPGj1S1HkbMZffvJg9bTu4sm9sog7UbiRILodztojuxs8pKXeGEUoAMZUw6TDiTXrDIop8GkZTlxOkmMSNoWbMiZU677xtj\\\\\\\\\\\\\\\/DD6xVNhF9e9EgTNSUbUw8LSdorfjTAM457ye5Y6ztS9wq3dZlRAWNgJqAbNP+5gm2tAb8HEZZz3V4kBjmlI61sRnwzDasK0boEb7iQXbj7k2qzB\\\\\\\\\\\\\\\/U+0KAYTjVZgr38SWMD2IAzrCRg8BmAzCYaikT4kOfckCr6aXxMP9E3OiBFTvkWmnlu6QvehSyNOzvQCyVVDQqJa\\\\\\\\\\\\\\\/zIELAUFoAW1FE0L6U+i7c2tq28qHZjnZHAludJ4BUreI0FXPQVPuNh\\\\\\\\\\\\\\\/KsFSRmI32wvUCFvGSUn+OA+t1W\\\\\\\\\\\\\\\/2QoFqBYzu6Jtp94KfG9nQbwjhNMQt\\\\\\\\\\\\\\\/Irg89B5seXTDY1BjYpYbykeNNoNx5S1uRfGG7e8KqjH+twJZ1Fk8iwq6A8YVR\\\\\\\\\\\\\\\/r4bAYkRKL67BTFjlFFML66nLj1at05g9+MdwtiI7zlHGF2MaynilSV+HtFzSIW0F8pqMU4IX2+FNukhJA\\\\\\\\\\\\\\\/RNnwQITePH2KlkybOO6TrV\\\\\\\\\\\\\\\/U8n0cDRRUrkCqpiLS\\\\\\\\\\\\\\\/xC6olloB8yDlbp8\\\\\\\\\\\\\\\/BWdxXUciBrUWgaYrV3f03CIq5kXk8tMOgPW0VUKPmFINzsIx7iififVMTYMlZsdsMOmQR67FndYcpPe6UcAhs2zlUL1hfknhKEjq6JumNdtWl9NQ8mOqjmwj+g6xz192LZKLwX0gJBpxNLMs9tIfiBDkS1ylAcWkpj\\\\\\\\\\\\\\\/lqeJ9l+CTs0y0xUoTVIUInkYcBuVq6WwntxEiIR5hqboHh3Slwt\\\\\\\\\\\\\\\/TVBbfS56k8ofa6hNRmo3MVWp2cb\\\\\\\\\\\\\\\/hIzmyVmI5hxrQcz9yIiXFjHDTurpHyUt0FgIpDRSgtQQC6nkGzfjJyEofr6rCUxQu3mJAB5aNIca+RsEEfvqB1jU\\\\\\\\\\\\\\\/aOr7JGGb\\\\\\\\\\\\\\\/r36uuOC9bI374Mxztquj2kqgCTsRdHBmxTCieys7r2GeVP1RuYhbyk5Td317kYNdPSyGJVsQ0ovxDr0j\\\\\\\\\\\\\\\/jEMfDZabYyYsOyY+iz48ATALO87WxTTR39WG8UBIKN9rdan9FPLqVlxONNTJR7ADECUZSojPIjD5CTqbqMOjj11fMzjxsQ6eYP2okoeqDr46NrQyqvJziiLFM05qh2cx92Bh1jWIZbPW\\\\\\\\\\\\\\\/433HrzJ23NylrFwBoJu5TfoHQYVrbmyFlY7HSGDdWPkxEYxyrgd8BMVT5jBrrLfR6QGjqXgUUay7oMSL6D7IhFhYPiYNQ0q7D4Eq3+f5ptdThET+MueW+3BGfCVmfo\\\\\\\\\\\\\\\/s08Ifao9OV0DOttrwq0=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022mHxhy4rxlSUZopIwLIEpIg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022c85558bafa362704438aa82835340644c96fea384642f7b6da98d3de1ff98a50\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/7\\\/e008434.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/7\\\/e008434.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008434\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008434\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008434\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}