{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022sWJCfdG6y3qwCUyvdHXZvxLDNVtF8L\\\\\\\\\\\\\\\/JD9a1WDsuWB4gHJ5awj6Wn8JUBd6SM+Z5M05HO0ft+6UNc9eLfDBKk\\\\\\\\\\\\\\\/1cMz+blX2CVoflqAAgwH8ww9p3AhRyF3G\\\\\\\\\\\\\\\/XsJLWwmSfGtGYuiQRDftufyv2gomY4azJvzTY+zibAaJFgZkvCqKjCfn25VsBLPNjr93wqpB9XmyWEiadITOLJAo+\\\\\\\\\\\\\\\/6LajKusZKZQThF9IbbsrlsUZKP0VlywNKr\\\\\\\\\\\\\\\/S8cYv1M+\\\\\\\\\\\\\\\/gHb9jwBZqdPCJp7APR1KFWVJ4ouhvqS+nzjq0wa29JX9ab96j0\\\\\\\\\\\\\\\/X8OVXo1pXDQ4bRjRvnIXtd+oXBWM5RcjWOtFgOcEk3MjrYYy8SvSvX4j\\\\\\\\\\\\\\\/dwkvueLghcUdR8cQKcO93eTpEKxy7HjJnIG8J3e0rCrWs9wfFBqv+s7GmEt9l6xQUotQ5fg6bhBBUwIytrVjrlNWNCptUQsB+4jSjs3H9ypJ5I0eT4zR5Wmzv331+Q341OPRYa+1jrEa84uT+Sfm1yn9A4yhKxPz+gve2YFRPVgCWQCX36u6ismY6Etdg9jI1j98+aCvrKVudSILSlnLpjcPX3CVX6IuXJ1gJyPieWvuGuAmrEyfuC0sgOMisHCFcoZ+AW+dKpSpx+elyarkCe9grMrygbk\\\\\\\\\\\\\\\/LCJwpscdfh6oWB7CdSIvFU7GQnkRkE5PYwk6RdC7XzYQ\\\\\\\\\\\\\\\/fzy\\\\\\\\\\\\\\\/dt5WUPxNted9sWdzXLWA2v+3nm0aqPALZAxiTAbGpaGdyRi4cYJzfZgGhC\\\\\\\\\\\\\\\/5H09U\\\\\\\\\\\\\\\/MTDDg10JxiaDuMtls0mVEqT6AqPGGLD2Dr6zmiIppqgO+BnwvNu44li0kU82ivAf+MoBkGTVD8OrNvXxxIMqtEepFsBoEmQ9OLRcHMjbPoeyDLQWoqm8C7kkpxzKcZMkSwOoMkqfnmx3tKqwW9lx4Dbeix5OB+jkwDNoKbxoPWuX+jatXCv6Y3xyuqABacoBp0gKpoUt0LDtZJuMOuOLOFaciVh+Gk2YOCoGmYbZDgmUDbv3acQ7eg5YcpvOLIuSOroHtSFZ2T2R7q2AsJmtna5OuDY4+DPdIQVQmeK300BDs48Tr5PXLLQ+c34hsmlJwNFAqxWqYe1+KXs\\\\\\\\\\\\\\\/UN7jazGJJjkw79tt06Ks\\\\\\\\\\\\\\\/QSMrxST6JEHr6mD2lKU94hebBlp5DtJxwP5tisH5lX2YJSyhAWG0q\\\\\\\\\\\\\\\/PBqgDPc44h27dTvrCCGjzk0rMec+zPlvmj6c\\\\\\\\\\\\\\\/mWvHaw3DPfZ2ymHoFy9uOU\\\\\\\\\\\\\\\/ZoBiSnI9yRPaxuluxjJM5zWmo0rj72NfVta3K11V2MTiIyO9Z71VVqTwOaxyt6X2G+aJntwfNTNuij8V+MKk1uTwhOXA4Gz91UoQaH7QZzYvK6KIFn7zSafCpZtz2viCM7pq9JqSdBoJ70vnbF3nTLFYYwy0\\\\\\\\\\\\\\\/XKV9A2Kkcw2cOgCKCBRRPThXt9q7\\\\\\\\\\\\\\\/Pxv5tWEWtlGU1QEp\\\\\\\\\\\\\\\/hIDbGITk1WgUARA8TBirAI6CgzIxLkJ+QxtJY5RV+1EwRp8W2jSUSHBOOPY1Fnw30I2K2MUQl7884BZhCOBhXHeS9cQ3L1dEgGvaKEbwCHsy2DX8AxOWokkBlDLQj416iS8LH46X19GzU8jjoEGLg968SEyAhwFvlSVDrz8tTy\\\\\\\\\\\\\\\/EljkX\\\\\\\\\\\\\\\/nkMyDOYTCZKcqEOERKLCGzKNWfXyTxXXCcJYkMz6mEjuY1cvak0Pu2JrFN2GeYN+ycI4sOeBjfV0F6dwXfPjCy8+po7AVM55y9MJJLIRLLlIX2hqbk+tIP5PIT4kDF0wwpD3s3UIBqaQNFcQLJnVYJBgnzBHU1z5QrdLEEshHM5fi0F8kGCQf6Z8FCa\\\\\\\\\\\\\\\/IcTMiXLb5gZmYq\\\\\\\\\\\\\\\/mQ0U04JF2p8pthawo7PAUNkpPwr2SEObEwCNKLYZrXgsZPBmxNqw+\\\\\\\\\\\\\\\/l6YankSmqrHBVzW+QvdMt\\\\\\\\\\\\\\\/c9+I\\\\\\\\\\\\\\\/hQXSc01fjFsIY58FOiDzq4vk0TYC\\\\\\\\\\\\\\\/eKbiC6K0Eewi8uQ7sU5GcyRKLNBjOR1ovGlmRu+Gmnxw1DKUzKUbz0B98DDetUFjSN7J6Q8hmjMrhX0IRs9V+2VTqSwi9w\\\\\\\\\\\\\\\/ahRXOUMTEzMOD962UOAAxwieDS63aCYT9HzI9eXfBfMp3VM60iwPl+oTK7TByRXiSAtDOGNWDCI7jjvQe8i0zyMFL\\\\\\\\\\\\\\\/iyAa\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/6vNOJbxQGjPrpheyXxfE9iiqfugOnmkgln+1JAKBH9hj4uSWQUBM95+H8w0TMEneELQCYmOaR70UEcxdhCeaf3GtDnyJrLOpTXBMR+YjslxmY\\\\\\\\\\\\\\\/cB1AsDzXwxY6QAPNJZsb+e3LQ82E+YVywQbrnjXnkM34xyXSnKz0MAC83kAbxmPlF2H11OdHIJOuyQUrFYZduP2QmrfNuGpx0h4258FsCwZvdgyQcMtuwUoujRXY9vKamJseE2x42BHqqnLrcCnwyb3wLGMSWaH62APuFBR4tiGbdam+vUagkuqwqhZqlqvS7tkcXlgrx6UvDHgKUWlCjfFZ0vtrQ0AYxOYnkkJTuOmteyRNF\\\\\\\\\\\\\\\/fuOEVpiujcRxIMugkjoSLbQh9Qj\\\\\\\\\\\\\\\/v1jiUZLnaLJ6bdHvWU8NJXAJTteosdnuqPh3i48SGgWmdbONazfo9BDxFLdKeHy208K2+Ny\\\\\\\\\\\\\\\/n1Cjl\\\\\\\\\\\\\\\/Fx63GkLxVBo0DADMViLcGztdNI=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022ZXqGjCw8kblGx8sQu7YFjA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002254eb496ec3999a10968bc322fe7cf40e4ca25358aefa6ee2f8214d267bc2193c\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/4\\\/1\\\/9.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/4\\\/1\\\/9.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;4\\\/1\\\/9\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-016-0115-3\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-016-0115-3\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-016-0115-3\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}