{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022fXnj9e+RGskJSBj6\\\\\\\\\\\\\\\/T7MpypcjNO9SDuO6WhG3WNRW6xW6+W0CA0R2bcQnm9xv\\\\\\\\\\\\\\\/cnPTZ9ugHNPGnsjzFGb+xsIDNzTHBkSY1hOMaYaVDemsn3Kk41X9WxX+vrI8rYgLAlYUAE0uu\\\\\\\\\\\\\\\/4VQA58IQVyD9wsUIKELY\\\\\\\\\\\\\\\/e28QUvXy44VbtoYKYu7ICchvJblW3G\\\\\\\\\\\\\\\/+70BMCosav4tUFcHXkrlYugvlk5u\\\\\\\\\\\\\\\/ZX\\\\\\\\\\\\\\\/mQ3fGuN2K6JHKBm+lQb7oOHsugp9+xtRMj8YJweDotiUrtBS3cLazd6yspQTySZQJhGY+2FaZn8BTLnFNaTp5kfbq6oRHNcJkvphXyY9qV89wjz2gxW08CBz+GEbs1OR1swLl5NHy27CDwY+QCAJSAcOzd7m6GQW4QXgtFrOcWwSg3fU5du8bZ9AxB6ospygxnh9zaKd8dhr5HGD1bWUwFljr9oG\\\\\\\\\\\\\\\/s4N6jTE5HTtRblR\\\\\\\\\\\\\\\/3iAohQiiw\\\\\\\\\\\\\\\/wvGZ\\\\\\\\\\\\\\\/vV7BnpAJ2RxMCxKuwvYt5qk8yQFnJHYdpMFSJknjIHP3TTBu\\\\\\\\\\\\\\\/r4mZWd0kfVECyFKXmmLZY815qLMC8bo2\\\\\\\\\\\\\\\/nyx+I\\\\\\\\\\\\\\\/uTxE9Ny6WItPpU1ot9U5qBKOYON73iLwVkHisoOmXz0jULeQCJUyJq7Zr0Dy\\\\\\\\\\\\\\\/ZnHRQPybPJhCv1SKVRZK8MmoJ6bXQoh3667aqAovlGsMdfSdMZ7BWThsRsb\\\\\\\\\\\\\\\/9BfJjiYD2+Z75BgOKMIb2BqilPV1bTRviUWU5G2wR0xb9e\\\\\\\\\\\\\\\/DmxdNEvuzisS+zpl88wNc0d6QPQfWGs9OO45NxnpXUp9reX\\\\\\\\\\\\\\\/DMv2rTOjSjo21Gw22otcKDy+Wzg20wBRom90vt0CM1zpiyeEhX7VbMQVrCwjd8u1xnKng2GrJXWAqBEJ+8lw+bTd6uXkyxfg5Xb3r+I56NKwRgn9HVrBtKsfS4kgc0pSPV5R1p8970YnSr8qio\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/SdKj7XCAIYOfu6ClOtmxeVdluSegp60sTrzq6DPhgiOmMYQdB2l+DR8t\\\\\\\\\\\\\\\/aryISrGADKucw7XlYmBfNB3ZkMxOPVnBPnpxMNfQqMxZ8SYlqzusOpqg1fiAJDWvRfifFBB\\\\\\\\\\\\\\\/4Exv1HNGpaz\\\\\\\\\\\\\\\/KmQqc+EkO3UXENJGJyIYdHj0307o3Jg9410O7nKxz1Twwc0HS888Wdg2S9WfqC0O8qLsL9\\\\\\\\\\\\\\\/1NwR+wZL7Xcniib3i7zX05FHKzr3TjdGVOiSca7+YYSGbUkPkcnjDHIoqctM9e70WOKxDNiNh8QxeFPUWZ1N3wARVVHklDXhe1SU+jtsUlW2bFV8iRvkIrYORgQsuCq+OoYt6MY4V54oKUOSK\\\\\\\\\\\\\\\/XIO4Mahwt3UUc9JMbAbRR6xihD5vkCtoPeQT3vGmjiVD9IbOrYMigUlgCsgU47pB3ESskWGeMfx\\\\\\\\\\\\\\\/Hux\\\\\\\\\\\\\\\/xAyRviTItE8IRKz0hCTIqya4ljA1rketptOczLpEZ+WSWDx0CwJz0WSuq7SlgYpHiwCDqRt6Ty9OY5DdxGj5Tcl3vN4zluptyoB8BRXFw4+jcyvyvse2b\\\\\\\\\\\\\\\/tL6+yuChI8JENNFPS6NTpLCg5H61vv6a+dJMmXRfto\\\\\\\\\\\\\\\/U68f1eXe9vBQLuyaGD3HQ4ikL8gQPjGrIEcR8V4Au5PgA8vJmjJNFISdsR1WOHSc0wuHcr44MkZE7F8aLMWa1JSVyRNwIilxTTo7LLMtT1GSUi3leF+bDrxtWdILVDg+a1Kzsj5G7cRoX5De3POu+GaEPauMRVkybPo7PB+fs9O7wzTpg8JkN\\\\\\\\\\\\\\\/Olv7BJPlia7WggWUinRUWWi0emo0EKJC7hxfuYilojZTIjCpzDY9RwhCPYU3yq0ARmVbBBQedFJqfk49cMIX2\\\\\\\\\\\\\\\/Q\\\\\\\\\\\\\\\/TL+M3MF+UWjwW6oXz9M8ypOqfEE8sH0S\\\\\\\\\\\\\\\/ajWdgLYm\\\\\\\\\\\\\\\/9TcIuYkaEHp6yTqzj2rs3uo8OxV6Gv4+XZVXbCqo8eOG6d\\\\\\\\\\\\\\\/LeP0H6ZJCHpaPwRyurX6v0eMMQIxJLXivQKff43lLmi8GMAX\\\\\\\\\\\\\\\/7M8RJrdS3wr\\\\\\\\\\\\\\\/7w9nzrs5fthakec1bbaqVYNqVK1NSCqk3s\\\\\\\\\\\\\\\/NGuj2UHpSu7jJKqTZfKTmi5QnwG5jb\\\\\\\\\\\\\\\/xnUYEo5TZUkcBIsEp7SQq9u43kLvBmcXkEnhuBqENp65Og40NF69gMr\\\\\\\\\\\\\\\/66v1fVAMAlYDpvstjChkpT4XsGaI\\\\\\\\\\\\\\\/6+11x9A69jgdzbHC0eOFkzFIdgrRkSGn6W3NUyU40rasswlcpVKqT9qr7ib3bBzflTVHbVeDy0Mzx+6IeJE+14T0rYNHQptjWIfZetupzlXvegt\\\\\\\\\\\\\\\/FhdVV8\\\\\\\\\\\\\\\/gG4qHma1B6KQlsnZAtO2AGGBP4ZRJgcZx5kz5D74OmCAYON1nVF89oxnMNK1LxtlaSuDSn3sNza2e8c3ziLuR2vajhj4MeS6VvbtuR+J9Kw1pA3+9WBav03vdBthfkjvQHiSsF\\\\\\\\\\\\\\\/LajisggtrWDcBbD0AurfjWyFqaeGtH0Z2WKWDsz6fP05yjm\\\\\\\\\\\\\\\/5D5NFvbaZecMwtZ8GssPXrDoMoZMjhgwB6vl4P9+Bx24Z+5y6FNjE9WFnzfOi4W\\\\\\\\\\\\\\\/2zK\\\\\\\\\\\\\\\/4\\\\\\\\\\\\\\\/iiOMbVZtVNmintL3GQ1b0gaRfdUMAcr86bW0dzPE9vAUAfif+H2RwqWzb\\\\\\\\\\\\\\\/RzruUBz2s3LUxQU1GwkvcU\\\\\\\\\\\\\\\/7hU\\\\\\\\\\\\\\\/EPj+rewFdXC7NuvSS5aHQFlv4qxo+2JF8uZXDFRkxPmr079CvM84=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022PLWdDOCKZ3vnLBt5LAOAmQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00226b8faad6a60f9521b313a282854a9fc5bf02f7447084ea6f551e1a5a8feab070\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/5\\\/1\\\/76.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/5\\\/1\\\/76.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-017-0282-x\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-017-0282-x\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-017-0282-x\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}