{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022yU+VqWIv9NoemzgWpClo+v3vJly3RWivc21q0JCpZ7848cYVX5y9fpBqESdwTqvwX7+\\\\\\\\\\\\\\\/3hYWv6IFVioF9LhCnt\\\\\\\\\\\\\\\/CbiDK1RDMOSy8Ok87gz6m2HriiYiTRbHR4sFFG\\\\\\\\\\\\\\\/9v2s8IMrrrR\\\\\\\\\\\\\\\/eaC0wUMiDwaEkdNSl69nbVlrUeo6F9kSTpyRp9V5eUl9nYXwx\\\\\\\\\\\\\\\/qtgNK2c0xwifEtS3\\\\\\\\\\\\\\\/3wlNzDzMQ17kJ4F+BofQ4cmtbqMVOGIX+Hjmxz4b\\\\\\\\\\\\\\\/n\\\\\\\\\\\\\\\/ri8yAeUucDVWxPSdDOIfrA6MUEoaWemlWsJ0ULP+6V7udd363nY2U52Ket50q5DYyFVk970Tjwg4w9ROcdONq1WrAcWkZ7moZdHwVD4fdq60H+1QKhL5nBThQI4lryqfUBJez+hDxhDVKkppSxCMsJHx5jfWhjR+hgUPparL9CpWhbqwx4lCGycvJUl+R8rxOVaEIU6q+tckF8Fr6C6k\\\\\\\\\\\\\\\/lPomsUCKg6X1ZdsHxxelBC4\\\\\\\\\\\\\\\/D2C9b2M1k+y8NPDNslFxBVH31UlWjd5\\\\\\\\\\\\\\\/VnCxg0bKDM91Htm68GzybvFiC+xUwex4uCn6XK4+CSB5U\\\\\\\\\\\\\\\/8O4\\\\\\\\\\\\\\\/3OF9TSdWpVx8fREkIQYilPEYOoiTjsMRZOtKtUkZ7YdjJ9KrBkNauKSJQ3nCQY+W9QmrX565oaoVhxCFouZjvbUZdvvL1ckMx2sMKvuwomCCQs8eTDh72hTvLEyp0m8WviZXrTDB\\\\\\\\\\\\\\\/xhFicwE8qfrXmI8B4HhFFsQzZbeLVik6pvAwJgnD0wkOjZrXNrnLLR2K3uYSVRr34KsHTXwUCzwWHwyiheXEv3YmldL5RT8uBg28wN07YMQeAIekIYD4Ocl8RW64L11BywI3vgk+pw05TUFQacSqd1EBz2MBXhOvNh4PABe4wfqN8IQV0i9jMfAdeMnQR915OQaH5OVGJaYYYRHfzGdPFBzsrDp5M3SlwPCa08HA4l5Vtk7oqPHCkGvFK1ND0PBanPQe9f8H3FFyiqX\\\\\\\\\\\\\\\/FbXthN+nBg4qRczqILVmZwDIqCMJQcVueAIhx1OJ5DioVuvpYeB5A\\\\\\\\\\\\\\\/73db\\\\\\\\\\\\\\\/c12sMXSvp2\\\\\\\\\\\\\\\/u\\\\\\\\\\\\\\\/qXnjpjSr00Eqa9l7z8RF41NKdzT6CUjhUl1P86Moqg4G5jiRbZD\\\\\\\\\\\\\\\/7xi9az2WnGRB6RiXq9S6lWtrYqmatlZHuze0aRaic\\\\\\\\\\\\\\\/X61zSOhp1Ifh6GqLtm+oTD7ue6IM3E\\\\\\\\\\\\\\\/Z8v\\\\\\\\\\\\\\\/zzIwbe5kCOlA49AuxfKJRdMTBz7IbhUgFBr3uRmmBF7NikqgvLB51N6SeCrK+5Y3gNQcI9zkS9awL6ckfR\\\\\\\\\\\\\\\/xHcgtUd70yotE9ZDKdIIAeGSJVlsOZ0lFBrsz08IxSxilb8KAjHySRviIaIMy6ZTwVNKg45J\\\\\\\\\\\\\\\/QWsjoQvDVGk8QcIr4fWuv5t\\\\\\\\\\\\\\\/JeY8yrea1fPvYUIJW+Dh\\\\\\\\\\\\\\\/dSzzq7DlgcBZH5iTJwDTmGLRrzUJ+4toOV\\\\\\\\\\\\\\\/GyHox9erID6bsOJKjODHO8M7P0ATDOSLSWqqtso05+kSQI+7WuErUlG3fIGbMNQNkmt69KAUdRflRM0CjMIcOE4FiGhM39X1N+ccBPo\\\\\\\\\\\\\\\/htOWE5xnK6oBDkJJrxLXQ+syPkCFDgOZFFxSBZQcyRindR14OwFXhm6L2WQf1naCy9fhjNm0DrrgwDjRUV+rzzS1btvqehuduPPk7J3Lw2kUjYWLJyD0TEHvolKa7n4ELfSwO0uD+l\\\\\\\\\\\\\\\/4OUrqwYaZZp0eSnJEePCoUIlwJcag8zdeKArRweT+IN1epjWg0UkK4b4vJ5ZfiNVmnHpdTGqL38JI7QW7PyawXNLkOaSASOfU\\\\\\\\\\\\\\\/EmBCdPbB0ja\\\\\\\\\\\\\\\/wBX1hhRlDIVm4ten\\\\\\\\\\\\\\\/GvCIXvDjPn4zsRVDrFCJwBLVidYa6g7TKANxdNxi+1yVXh6AR8cdElDX6TMINMskZAaUcFAXwKwiq05cGji2UazpMwmazkO+FLAPICYZEnJGwrtnjo\\\\\\\\\\\\\\\/BCWe4za1x49ZjZ6zKDndUN8Svf4+AZRKy5RfAyueYsCUIS0vNzoyObpVNbEWxKIcYt4wFbwnjpHR2kPnhXkCYIGM4D1\\\\\\\\\\\\\\\/PLlsraV62kBoJgP47sG9L\\\\\\\\\\\\\\\/z9iTL22+FuzCtK2\\\\\\\\\\\\\\\/6AB94YJ2Qtdp7k3YsCTOr9nePw2jX0abPxcngdv0W93LWub0D9aG2HqSq8pLo81f+GvlnQehz2zjv6b+dJwMZIUODVP8HToegQ6X7zZHbuHYteuZ0VNRgtNIZb4Svl\\\\\\\\\\\\\\\/XjMt+g2PlW01ymQ1wWRuUDy+8\\\\\\\\\\\\\\\/v0p\\\\\\\\\\\\\\\/8urzGI4VJQKoWwoVksGPUyY3HzTzXl2ggsbYPBdpTo09tzRbLuzLd8qmJohpBo7I0DtkxR7y1vUqOkUD7+Ni9Z3BOEn9cX+x5uzXIpJtMTJz9vRvLSpo5GWot19Tz7c7FdXlgS5kXLjuRxCfKpePysRtyc7EYu+Lo60MtQ9V4Mc+yC+A6ajaq0cg8a31HTUFa7QprkMUoPLi8EOAWxYshV2zIrUFIn4vqf2\\\\\\\\\\\\\\\/nxK+gOqQAPC1okqdvTjpriwyGFfAmi52Bw4bWlXmgQ\\\\\\\\\\\\\\\/2Xs2ECoyQX1o5lY4jpH3jIQkJUFBCJ7nyM69mcb+z+Sz\\\\\\\\\\\\\\\/QbMxLSZ\\\\\\\\\\\\\\\/+xIm0UxQ347K7h7OK86rJl3Fh927NHNEG4scKxuAe1qP49Okz\\\\\\\\\\\\\\\/pVtpBHrgLMXddORDqfD7l6FeQBSvQADgNG4jfbO\\\\\\\\\\\\\\\/SNuo=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022NHFNGlyksxxOnAffuz\\\\\\\\\\\\\\\/zDA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00228d93830ee37f38531014bf1d4db56be9d1ef13336f6ee893bbe82583de9b8165\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/6\\\/e008364.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/6\\\/e008364.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008364\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008364\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008364\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}