{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u002251bYABzQPviOGt8CIgk1HBjnnITtlmwcmhfT+ej\\\\\\\\\\\\\\\/UhsvzBNYCUIKXWyGG14QzPgzkZ80Qi6rdQ2iC54xPl54x7YRvjZ3MgG2Ds+I0lHqdDCTRC6qKLI3\\\\\\\\\\\\\\\/3NHnwpZlBEll2fYqHWM+pqJLugfYYvYLuDrI3UNBe4V5BHBovJ4HpKUH+0HR4nLcQ2LX+8Bt4TcIM8uGvz2wocfgJFmtnoJ5K\\\\\\\\\\\\\\\/buwUTX62iQcJh+65Fqj++nnR8UrdhqJlULB3lrvwtRChZZhXBob0P9EQaBPbIFLEjkuC8jHDbiTyu4Q7kdYm4z3M9GoRXRjiN9k4UYmQo+aeLxDu1ZDghdZWvzCkGIXFZQTLEW0aB8plCKDPhBTvXA4a97VHs6\\\\\\\\\\\\\\\/bKAsMg1IbnS37zvCzwpMyNG55U74NklKazYR\\\\\\\\\\\\\\\/AT0IOSRDuv2KlMIKsDW\\\\\\\\\\\\\\\/QI0pDQ3gEU7V8L\\\\\\\\\\\\\\\/02PSpquUbUS8E4d82l\\\\\\\\\\\\\\\/dwMIVwc7\\\\\\\\\\\\\\\/56WqiIjptXSwko4YPzf4rLelbqjjmLNO5n\\\\\\\\\\\\\\\/G80tAGD+yZ+vUxy5DB\\\\\\\\\\\\\\\/IEAO5auc2O0tCeNJY1ylrJ0lpBv5oqWU2aFTABRb3mbPA401SxkD+xBFio6KscYGTGI+mIKFgsdoD9QQ6xIpEPdauJemhFbHOhSpY0W6I3BhzOqT5vd3Y7P8S1cPawGDAfCDpwxpLziaGu\\\\\\\\\\\\\\\/YQoAkLGA2EpddK9v8\\\\\\\\\\\\\\\/KFXi45Arbaq3bzfu12yaE6dky9ZJY\\\\\\\\\\\\\\\/PsDiL3gpP\\\\\\\\\\\\\\\/RNZfCfcsAUFKkNuZIyr9etAcjfsz7oaXNGSnw2Kc7f4ZTAbbb7KTdek8wnI1m91xYxO8e6s+o9FJKMd2zBPou6EYaus85MWsS8BTBpL4z7xNJToeO0GAnTrjT3D76TeP6hZbs11ljAjZgs7G6VkQdCUtTAaDQg4UmDXHWgk2st1QIbCD0fLVK90\\\\\\\\\\\\\\\/znqRv0N9wXgr9rw\\\\\\\\\\\\\\\/kkODuzPpT4qdPt8Wh\\\\\\\\\\\\\\\/t6U+w1rS4IW8LmKXZTa36\\\\\\\\\\\\\\\/mYg8kwuHhdjcOxmHTWWbIEYzcg\\\\\\\\\\\\\\\/VPMmSoEI2gpcJCGoPMek1\\\\\\\\\\\\\\\/W6nJUghLvsT8KHVgMal+bjqaBT8ZcIZhofSvbA1iRoW6w3wEHmfbMmwzIGEfMjyhqtx1jPaVf0gZTs8MNApPoPh1VN8fnouxzf4B9N0A2wcjV5gNhbkaLzFthlnEGAo2GNdB6Wzlwx4p+t0sCGPSJqPyTa7UM14CSCZfxLaDPz+au1iuaL25vzduuaH7nt8gwz7CaEZdkssVPKxIh\\\\\\\\\\\\\\\/Pz\\\\\\\\\\\\\\\/qAq7T81tE\\\\\\\\\\\\\\\/97rc9BJb9bI72fcQgdkdb49YPRcXg\\\\\\\\\\\\\\\/ajI\\\\\\\\\\\\\\\/Ls792bZ4ye+hgqp4nNz2kbYqPw7D3QbCAIcLz0ySvUp7NApG0znmjpLKMtDH5ID1qatxuQP+IvgbVz69rHP4ou84U0AVDWK1dFb0Bh8T9nesyS6Q7rMOPxK2RbD+mK86e5hbzO\\\\\\\\\\\\\\\/tOcjFnYHTFvnzSnev5jZKOHoMmCh3sJldJQhVdRVNBbRJdA1VvGhshnM8ZOA1fJOIFLtskPOP9tMLF0w4O5w7gJVHoxQpEgdWSgytmCkeqPekbJZcEdmyxPnUMs4LZFk5yw2qnJy+0jf6HAHvYruUPcBAKAj8T\\\\\\\\\\\\\\\/95SNO+tiPpR6PjfCeDrnon4UYOjR7UaOn94d+F\\\\\\\\\\\\\\\/L0gNwcNi61d3UZE7\\\\\\\\\\\\\\\/+ktW5LI6ecsMSor2S3AZeLZt+BPNWJrVFpxuGbnFCbZTacMQcSK5O+PeiLI6rrII50aiRQWLxxEC8iA2Ul1arGKOFe8t2aLa4W394I7HZe7eXH4HvRaQXY4jD\\\\\\\\\\\\\\\/U8V7FR0v4KzXGSd8fRwxHeDHnGthRTPqLi1eUQd3YfPHJ6JmB9Yw2Wb2\\\\\\\\\\\\\\\/JInO2mUI4yQPlA6f+iB9lkW2M0+tqxaJ6D0fsEXM0fDXvBYAtoNnNogsSSuf76T8fclu2FTul\\\\\\\\\\\\\\\/2rZ7YKAbDDquhXeOjzm6yEbp3mZ3bBTlgdhGaM1t6Xa6O\\\\\\\\\\\\\\\/PtrP6xwZmNUif+V3UZV\\\\\\\\\\\\\\\/T51\\\\\\\\\\\\\\\/iwwOhg7WezmJSjT9SZPtrmcA+P0I7IZP4Rlyf7UwCerZ06SEKRMf9H1wYru1M860usIOWT7r7llx7WdOm6BYFBwaNgjXHnvs4vInHq3sLZWBQSlNYSyFt2n3FbPSUVkpZ3Rv4KPp5xnGSdMcHIaYsHr6\\\\\\\\\\\\\\\/CjApoFj6DcvBE1kL4Jtr6qxn+3ZNU\\\\\\\\\\\\\\\/3NeFnTpKFR4BPfDhFQ\\\\\\\\\\\\\\\/eMsgVKlpL3JCAKrfWj9PGffxrMnjxLF4Cwaaok3lDQKVCdgggs\\\\\\\\\\\\\\\/FqKzQ7R5KapYmhkV\\\\\\\\\\\\\\\/rUTSnHWDzDjpRccs\\\\\\\\\\\\\\\/cbNwV8EE9dvHtnbN8E2fh\\\\\\\\\\\\\\\/1kWzGeCZu8iOQSnw\\\\\\\\\\\\\\\/8GJTDYqI\\\\\\\\\\\\\\\/FG+mC7IvuHpgyiniMDHK2OjkcLNh0iwif5Tcbj4H4oPdLRopxO7P7n8ozxlf2lg8YTl+U2j2\\\\\\\\\\\\\\\/ldJ+tXWZcnfggchSMd9f8Yz5yt40Xh15v3lsJ9gCyf3IqEAVIfqRGCFGgJ5072Fe9Kw1G866tvvJzZr5f5HLyQnPQG79MLw\\\\\\\\\\\\\\\/L2E2MoEVyatMTfjOaK\\\\\\\\\\\\\\\/rzY0FuNS5KYo7ZXHHmiMB47ib5Ol5amcTpObTaa6sv0\\\\\\\\\\\\\\\/8K4YrGqD\\\\\\\\\\\\\\\/TccyCYfBE1UYr4gViPBS879gcpc22WusmXOMK2WEcQDpyXRxG0Qmo5JflH4\\\\\\\\\\\\\\\/8QKZChWohzbjwWMJwvI=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022btimDjeh3gOn54KMzMmHow==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022530779e64193fc9e54bb83aba57c6d98d7b15569f67f5ac4d673bdac7beee3b8\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/5\\\/1\\\/35.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/5\\\/1\\\/35.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-017-0238-1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-017-0238-1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-017-0238-1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}