{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022XNHwpXluhkRugV\\\\\\\\\\\\\\\/ek69XDen73wb6wps2qlL2cIr8+gESbLnHTObouqtDE+RyY\\\\\\\\\\\\\\\/XD5iFWliHSkCAx0\\\\\\\\\\\\\\\/gCMbp62\\\\\\\\\\\\\\\/rwWDbdVsuLJEyIFxljACS3fLWvNATBqBJ\\\\\\\\\\\\\\\/H0QNCXbDblKy\\\\\\\\\\\\\\\/EJLt5hWyk90OoySHTgPY\\\\\\\\\\\\\\\/N4UTDgLLWH9RyhQFvK6XcIrElrqme6WhV3WGk\\\\\\\\\\\\\\\/jRXVoxvjayxY\\\\\\\\\\\\\\\/ukGaDbFwZbwbh67CMv0Gtj\\\\\\\\\\\\\\\/2mC5q5kJHpZMA1GYGjlKmo\\\\\\\\\\\\\\\/EhgPwtOTHN1xxiq7FcnRPm8LTtcNWB0Oa73Dr8klQyrnsHq2X3qmKVI0fupdtNRK\\\\\\\\\\\\\\\/U8teUrWaqfwPmlYW+sXVmSaxEj8rmTM67jUP5aU48fqOTJ+XWfXof9MjAsSJ9FheMt72LqAtw+dvn2MgPuUa4kqrGHPnGbZqjkW43N3qU1SeIUS4o\\\\\\\\\\\\\\\/XwpA0yC0calY\\\\\\\\\\\\\\\/z3GyUO1jMRPBCAGRnSSzvKNh+l90kqKkxMnJuIhe2Xj7ZYB7y53W+JN9+SCLfuKiBaWQAQklpItb+hoGId9FlcEJbDIsvbJf9XHFesVXUEx5AtcQLTVv4\\\\\\\\\\\\\\\/r99oCK\\\\\\\\\\\\\\\/t5Fyqp01rPo8Ao23zVue+cWSMDbCHzhoUh0TSypDb+FG1DqTiLDcXL0Vw8dRCOajLrWnLpJDHS09VIrourcdpPtZ1yLsR\\\\\\\\\\\\\\\/Dbod3JK68oFhiZlb8ReGM6CovXj4cwB5yvQv\\\\\\\\\\\\\\\/cH7PPWXnuSPHZq2FxHxEmF+Yy5e+3HNNi0aAoEISKNzKoUin4ScVmHybwdwcNglWPhSl+fFt1Ndh9a2RXDc2dUgudpXEpLx6gBk0mcpACMnMv9Z3Zqnvcc1JtI0SNjiUPBx0\\\\\\\\\\\\\\\/a3lK6rcMkf1WBe3oCsiSZjpZnkUdMNlJW3SykMrFToIlYLU8cJEi07RckZkRfNs8OEyF+sx5maxDTSVU7p6XKfLywtFV5cPB+CmLJ+k5PpgqhTCasEPtPMBkiyKry9fT0Afu165tkigZnNNTq\\\\\\\\\\\\\\\/ay8gOzTvtfHk5f23A6UggMmrAPXM\\\\\\\\\\\\\\\/wW7RC+tP7PddTfmyi0M1kH1kqbot6EOT0VQ\\\\\\\\\\\\\\\/Rqonu+e5zHFgGg3eCH+no9KyFKQGGYlKKDgg5Rdkfqgd8IIID1+nckCmuKqlYHqAjBi4zTN2RFtcrIF195A8vdaWjjOtnSyhoyvObXC\\\\\\\\\\\\\\\/UQUXq7onCfHLuJNUKhnj5qF\\\\\\\\\\\\\\\/DoWmaU0yE1k\\\\\\\\\\\\\\\/fYvzNt61DyCmGemgcVc173zSbu4APwBweOPpKjRiH5eZhzhYJdMz0LBYaCisVHEpgYGJGHZl\\\\\\\\\\\\\\\/otyjTTA\\\\\\\\\\\\\\\/TSWtk7rWAnnWckIUywhcrWdnbn6TkNy0G8NhGT06z0dCnVEOZwkUWwVqZQd0uLILNWMd8fkKquT2CXp1l7tIVeIOzSt0bgLHSs6A4+q9V4QfArTcOX\\\\\\\\\\\\\\\/kw9tyOhS1wFdfnWB+GCCF9AbkXLdkXk08\\\\\\\\\\\\\\\/mcLzqZ3QNrHEKWHeCE7TGZX5pe1t8PH9da16yrvTd9tc9Rd8pT6XGVhbKSHa57CUaRIkzFDFO2Va28oj91pWIZU+fjnOaxpr0i7Jzix2vfEOEpw112rN5SS\\\\\\\\\\\\\\\/fm2wmsWAHZc1pTWa\\\\\\\\\\\\\\\/rydlgu22iLl0AItmUUqRdaDqHq\\\\\\\\\\\\\\\/FFHSA\\\\\\\\\\\\\\\/cMhWj+fHWWndy1Dj7brepAFGRgQ7gCdpydqbUwsd4yAW1ebAW4U2MuDajKcguT3clGMWbacObI1cL0r5ORtEqf\\\\\\\\\\\\\\\/Iskle\\\\\\\\\\\\\\\/3W2NrLxGyyaKs97qDtcrJdmkXiYxLyGy57\\\\\\\\\\\\\\\/my3Bif32wmxiPA70uB6Zll1IGqen59hfDXiU1+Y\\\\\\\\\\\\\\\/u05ngjL4NgWyHVr7udE9k2bw4R7izIUivQD9AEPZ8IhToBUy31JJZk8fnP2jXiNWAiUsF\\\\\\\\\\\\\\\/8+V7jeDoMY91+doD3\\\\\\\\\\\\\\\/Ie29wqr76LiGNg+hDudbivni33x4yEjEpqi1U3PZS7H0NZWTuwpE3\\\\\\\\\\\\\\\/a5ryo5VJI\\\\\\\\\\\\\\\/Qmasemhv92tusGTbRCefpjv0StIKer6vNrEb9aBP08mzfwYMiffwbctaCPrYxYVz18ql7HJoDWtr2ITZcfBYIS9Yli1aEBedzzNdjbnQHdHSvgfBof+32CMldLfz9A\\\\\\\\\\\\\\\/ctt+gPHI7dN1yPA8htWThdhXXw66VUwABO9J5uf722PHIevYEmyp7zIw\\\\\\\\\\\\\\\/7rOnuEHXRJYduojLIPWdS44OFyWE0dT8b7ep+z7JYggfXid8lw9d5U8+SKGuo2xYIMiTFL9DNolzi7ifpKSuCYudyuTXq\\\\\\\\\\\\\\\/upVuZiKvJzZpgRNGXqiN\\\\\\\\\\\\\\\/Rd6b3yAC9R2nxvn5\\\\\\\\\\\\\\\/RR8zJ2l4ExlRy4ITTUsqynmSxTXc3Ngpt1aLKpuk1lbtFP0EbSjeQY+f8NeHlKyecRMqiwI7y5i89LgBFkrGL3c\\\\\\\\\\\\\\\/obgYFPvpe2PxYFnq6p7Wd6iR7dOiaHF8WiHbcpZwua3nZoIj6vbU9MMDQmQ8QVvegBHhLmzR5RV857dt1LCVIHDHTYnfwBmNjBPnOT+BCtfDlwUxZSHf1TSWtbCoaCmhg89aLg0nLFX4Wg5cDU0+6tgyPIxVKASPNCB\\\\\\\\\\\\\\\/QYRtSk5GIuQ311FPwCzxeGESvFndGLuY6igC3QCNta6gssYDzvjoczh75x3RV5HrLdzxCEcBvZ0oYamHMk3GHi7KMvbL0tBf4EovSpvGnBPmujzzgWbuUxteKe+\\\\\\\\\\\\\\\/HnGmDdZQ=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022NuWSCyhcM230Hnq\\\\\\\\\\\\\\\/WmIrgg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00226293f455236d451b2e3d34626721552a5b0c12056623c37c62c930918504a8c2\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/5\\\/1\\\/84.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/5\\\/1\\\/84.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-017-0291-9\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-017-0291-9\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-017-0291-9\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}