{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022CbvuJxz9veB2lDj8aZTyX2AMYFQMDQrIWUcEqd0pL76CSy2posCp7AxP77jwjhP6Hs3PyjGBRYq1GDEw9x3542VfQtIKI9hdk5CyH31v4VYkp+6wPyCVgbeYNHTyH+OLrpAih2rBLJxGm0kXlj9Em61f7vNjFG2Whf5Wij7PpYBON8iF086Bw25LIwHePpzHvOlTKdmbWQzwA\\\\\\\\\\\\\\\/CU8i1U9q5TIWG\\\\\\\\\\\\\\\/E5dpSmXAfRDxUVZmc\\\\\\\\\\\\\\\/uZu3+VRWo4u4OAkHoAoZkrvY4ScPg5PZYahCxIbHkhclzJviAX0vbS+eXQU6+aP55pCV+b9vv7XWz+iz8Z1rYF36TuDu821IaIo+4PIjZi6wsoKXxDLIUiPrwe00qjli6nHcBPJM6hULjdy7vEi4HGeFPNpIJT8TbeQFktSjfv2f6bsaNLtK3MDRPySOZHKMT89loTjcQB4NxRnhEn9OXM8c\\\\\\\\\\\\\\\/QcsRa\\\\\\\\\\\\\\\/N7T9vO8JXJqVy6UApaW9WL5t7r11siyGgFrCcRHlhnkAT2Qas7L5FTM6PSxSTjmZI6MFCQyvVS84N2+lzkRBCEKCLFysNB0jkLrsi+pOc+BAcqTIXOnhHki5F2D\\\\\\\\\\\\\\\/dgBDnSilhgj0QlLwZPPICfeJfpcKfU4tHJ8yF65v3pHHJ3fUY4GkDQkPLljjWF8fnLKmdo\\\\\\\\\\\\\\\/4KiH59Sc2ieZACMO+SJDHw\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/TlMBR9Byx6GxqNuXsNUmJb1sJ2EZwngFEJuxq3zzjHLR0\\\\\\\\\\\\\\\/Z2FNJ4ea0qKE5308iwlIbKfIO5CGlBKbjYYiEuicc\\\\\\\\\\\\\\\/nWCnBjtNpggF4d61cTPggYD6O6n4Vt8GCJah5uo0IFaiysv7p9XySew4e0NvgcPM2xERYy2iufQOnCu9sHVYXHT6UG6CL6QRXKJjaWH33CaQfukHKdShfbWtAdHAcBfHbq6igvSTV9SCJWXb+y3mVz1SmCfZAcIsy0xVoFHpGmeDaNWeHZgsinDCV9tzbIvurmSqPSpIQCUw+Gc7zcktHPCOTrKSxVatcieB36WktVZD1yTYmpxF+kON3OssoU7DrgASeCMnMWijkpk+UtoDywrab3nL7aDY87JgNlKJzdisZ3cjyhwILP67M+GfYvGMFDuvsbMwmoRMLPTLZVm1naHcDDZAXJoymzTQwwhubrnLcICHzkJ25zrVFlePHlD0xJZs0WArWV6298pOF282x82zDLtE+N\\\\\\\\\\\\\\\/Mv5HcW1S1fnPRJvu7VIsKuUa3VwFNnatjneyqKFVUak8Y2VVB06Pw2OET5oDlpzvtuAGm5KhE\\\\\\\\\\\\\\\/ku7v1ZCl36lZdIXhTKTa9In7UNu9wlRUH\\\\\\\\\\\\\\\/L+oeA2HkGuhjLpboLBJbh3u8sLt8\\\\\\\\\\\\\\\/qXIHIEMzqPMpRn24bXpavWO9GP33PWduQ7CLUFdM8C9HWnW2T3w8jXIEn+w\\\\\\\\\\\\\\\/u+EFcLfWZeN40kZk3WUs2xCJVaCIwq9V5HQewsEf42i+bE9QFDhAlfXPWO1LJgU7J8QaXY4TrbOBAMddOy\\\\\\\\\\\\\\\/hcGuBgR+MVwrvgkdcgPEJW3Lo\\\\\\\\\\\\\\\/gjvyUxJCejc7QIBKOyoxVuch86iOkjgxaoDqxGGEH12Bgu3wcRK8daP+mVHj\\\\\\\\\\\\\\\/F4+FXfPxVW7MehumOnHdbS\\\\\\\\\\\\\\\/juFpmwHbR59JCdC+muRwIfRWaY5S9Jk8HBq+GiNRngreCTJz4rX\\\\\\\\\\\\\\\/d72GFaGlwnAPmN9VTdUrN8bmml+oTmaDolCm6u9CkncU6Q97tv58RHPWOs5XXUouzJHtB9\\\\\\\\\\\\\\\/CGlR+Ap5hdPbi9VhsgNQzbyeukul7pk\\\\\\\\\\\\\\\/TKuFa4N8La+zjajw5\\\\\\\\\\\\\\\/is3ib44e\\\\\\\\\\\\\\\/oeLrk4QiBCVd3F9SFDMJkD0V6VzYdkwekxlLU3oLEL5kWFOYVH983IexGy9XNnAhDXbBc0FpyVi\\\\\\\\\\\\\\\/zMZ2EcAB1gFlhzYwsSn3CybTe+6cTR951PfbJ5XeLzt89kDf8rk\\\\\\\\\\\\\\\/InTfQjnvn8hm8PTeZ4gB1ENVb+pGW2we9S+8ZXtoWYOhu8BkGbipenid1pdXxdQlTVJxKYMQHxusKcMOUVJGjpRqciCj0l3UzlfryedFrupyZdpMmg3dcOB6QKWG0GDpS+RJqLFIFAWgX1F3nUTtxuAo6HWnDgmxeuHA8BLzJkhqeTlYG6g3IUawwO2gJvONeiXeu8TlXvfXxwGxnrUEjyAb538lveht7kiNtIB3EFeycQzXXkBP010T9nCsLTC7PjI2YaUjyJZL77VFpCNi5UWGYOJbRKyNVM55KGOU7wVJbVOr6LPj3HpcuhlTVzeN6rglEA7gckGXrwr0YBtRVoIgmsAAFboVb1aQkenfupQswviYwxsq2hudY3p+qXInjru6fs+JwakSJvRUSGLdeN54ztE6QXLxRF\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/BPW6Ljud6WDmGhofujTjnaojlohv+SpwgDbaiuDwFQfDKwq46oJO6YhNuFYfVwj3LO4\\\\\\\\\\\\\\\/8DUgv2Xrra+8vnw4UafjFp82YfaUUVraJJhGtgW3OKj\\\\\\\\\\\\\\\/CJ5I7loSW3diZ2UdUU7stWMaQbRpk3psANFj5NfbMYG6ZwJ4LwqXqGR6CBB6Ny3zQSIEFXFdI34wCWu3epziccrVw8kEhzvvy5sdVt8iCWcBQD3w24Kwd2AaJC4sBuXV+r+MsLOddxoUoAMy\\\\\\\\\\\\\\\/JmmwLh3Ak0ZJdME+wYzjNCmIGRtrhnsCGSvBFytMlZg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00225t2\\\\\\\\\\\\\\\/dBwkEEoV5WlXY1ucOA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002286bcd92f44f509eca0cb6b5df03a83029937b045a06d91411851ba1e4f98a489\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/6\\\/e008613.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/6\\\/e008613.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008613\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008613\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008613\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}