{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022cTJEGQeZF84rLKJNIenX+sa5MX+ZLosRfEoHHgdVS+SW\\\\\\\\\\\\\\\/qKZibJJeAHxi3pfmy8c2miEbLCBn9wKNOsT7U8BpfPDeZ3IlEwIz17TJr1YjsrXD5t7X+tv9dgV9zBnlkfPt4OufqnLp6cCJk+HSIEkWbUAChSLkmXE\\\\\\\\\\\\\\\/njXBkeR+\\\\\\\\\\\\\\\/3KTF5qkXd8AMxrjFGTkCVKUjm3dvVbpAlKlTQ5zQpX4D3iFkTBcfmwJ6xXw4j4h3Ki14CRjd+GZHhpmC5wmZlMlX8aKQimQ1CJML0HcxpaIaYHX43L09+CkOgC3eucX3hh9g7HQyoeHN7lrYieUamYvpichpp7n0TkWBitU++iUzEMA0MA+gkbdGkeTKKj3UJDHZQATLKnuVRaNPhUJWz3wInMKV9yBO1GZQAevnEzefHQurZtvBiiPp0kooENbyS7hjvn8UVd1QsKZ\\\\\\\\\\\\\\\/McF0sqXO+gggVi\\\\\\\\\\\\\\\/yob8DokT7ifjrqMdPf3E3hha81hMriAnlza6b5i4jGZwrzGD1jzob4sqZLhGRBCfauB\\\\\\\\\\\\\\\/fhJEb2ehoYYdlf1LQYaqpYPCFE0Ul+d1hfMvKHy9kO71\\\\\\\\\\\\\\\/mSMKl6YS8NltI9uFliXMOlHtIUPmGn5LxdOl50zCCE9s3hqvvmqdCj7Qp9PZJLXcRRM3Cj8SprkYZcW1ykKUrLlFaS1PaCR7LSu0OjeC3UzAlqH\\\\\\\\\\\\\\\/e+103NLo\\\\\\\\\\\\\\\/huwv4k0WnXsZ1YPovj5wr0tQ9JculyHQuaTGoC3Zl4wFDgy3JDrBq6uECRHFAr5paXyOngd16Phk7fehYxkn8pDzK+BsV7eWJ1VjoxAPEltSr3m89iCV70znrrLdWrp66dPsi8tk24w8tGL5NDyXlA\\\\\\\\\\\\\\\/pEVmGEy5Uwkw8alM4Cif38FbrA5zRH\\\\\\\\\\\\\\\/yK2t9j+eHaJ907ZGoA9Q6mjhVDalIjFuBwlP55lGJ2BdxBQA+nSHlZJaFvsILh0d+XanRze+ndoJkoToq7N+KwgamQSWHTLEq0LrBZJINhUes6veAkh8bzaAIjVAMMmwD2MhKEtCiCP9\\\\\\\\\\\\\\\/tNjwPE+ar4jCdKznEu5bcp+RD6rZq\\\\\\\\\\\\\\\/Rp4aguGRpUwQ6YsHRvNsPMyijaBGvu0ldMLJ6zfJWNOQ80Jx94IKBo9TzieylNoWspJnRm8EWjjMx0t0DXXoxTVfE0i6qryKAOtUODFzvdfI7oSTzFBeoTWXx5XVtWcw2WGThIFaMP6t5fCObpLonOTjK5dgSfDcBRD9aEZ3bDwv82h7tnRdTsgNLHKf\\\\\\\\\\\\\\\/de51PiXhZg474CfxCB1FyoMB2cMYEoAwpHZ32jVVDLlOMJSxn2+xJKBmrGkislBKi+3st\\\\\\\\\\\\\\\/p+PgCTIkOH2C6UDVoxIMif+n3z8EUh3kSsBRbcBwsyRPTkTenql0pBdoJS4Da4G3fQmqSIN9\\\\\\\\\\\\\\\/UEe56HgYBuPz3t6ydvhG3tYnaNi0VRXrbS3bSP3ck2BHQiwBA8wQ+oG+gcbTROdBk86id0O4Yf4n+GdRuWaoWP8\\\\\\\\\\\\\\\/9\\\\\\\\\\\\\\\/iSuDt8cxoFguzXEmJYxGtu3abE0uRnNqJh1Rzn5EHMd4f58IPIdHEv7Xnrc5PHFmH+pgBz9OMJap4A5meT8ssS7sGgsDF04OwOBJcXbBNkKI++o\\\\\\\\\\\\\\\/OtYNQh4th8gFip9tL\\\\\\\\\\\\\\\/kazMM6s1N4Vtepfo3zMZ9O4K9yb\\\\\\\\\\\\\\\/FzAXu1H0bz9r+4rltKvUZK\\\\\\\\\\\\\\\/zan6MgV6\\\\\\\\\\\\\\\/KPpxQrzOjD3r3ACaLugnQiSkVEyQ6S\\\\\\\\\\\\\\\/NqkC2H+r2d2N6zYDVgY2x4aCxmxXrkkDp4D6i4K8EiifvP+jCCsI7R1yW6jXomaTWsazirPuiPOrWoVjAgjP5Y6+ysIJiHIszQYNKGUbjOWtgfGtgYKc+3uSxx7v8CdI9KBG2kuozuOz1gcTDGFhzqp4Gfax+78vYVp66P8mRTQ6ChVYuHCXt9ZQ33l6tG3dUdmbY\\\\\\\\\\\\\\\/gz2KVerqbsu0sFRQtGw8ixdPf1dhG+cmbaq86l29GuThfjP2xrUGX8NltMwXAA1oiupcmgsfwf9\\\\\\\\\\\\\\\/PqQWK3geyWYwnEjLHRFksKK\\\\\\\\\\\\\\\/+qCVEo26RN0OKEIhXqpsEiVwJTI5rn3aO1pmO6n+mmF6qTlBMSDQ7ip05R6do7dYuLPxUrH6pO7Gibo1bQHkTx8hTfrzzWnatoV7WTmqY9VhaMzhS3J2IKqGwpYL3xvZcnp3DRPFh\\\\\\\\\\\\\\\/A\\\\\\\\\\\\\\\/g+tZPfx5LJx2H8nFelJItmmxNty8dLI2sZAc4vEv9paWje49bJRiMHI6pkSnPRg2eyeye+Y7hyFNdIivpEA41y0vceMPq8T3HGPUX76RlP7wtpUlRS6r35TYHpkWDGRT17W13oJyUVF8WrHypJTq21uhY\\\\\\\\\\\\\\\/Ro906TBOz2gore6bE0XxPE\\\\\\\\\\\\\\\/4A\\\\\\\\\\\\\\\/73eAvXC\\\\\\\\\\\\\\\/aGyvZuh1+HVKdrEBm5KM+FGOPuPqSCkIhmSDWft\\\\\\\\\\\\\\\/qQaBMTG1o68PcbUynsC8B3+If6\\\\\\\\\\\\\\\/KgBDQsGtN6ATb6q0ekk1Fmk4ij+vqCBXg5G2tM6jeu9dSEfRn+j70wGag+1hMjqlhfO4te0bqUgtQ+HS2I5Y0phnsWV84iPigoHa6RRFqygTU77BZJuSEC3NEMlNVGigzwNs7cwgua+\\\\\\\\\\\\\\\/86g43UdX\\\\\\\\\\\\\\\/CeP\\\\\\\\\\\\\\\/tx41m7swBV2\\\\\\\\\\\\\\\/3g+nh588DhdC20DjcbrYDmuhbxFzuPm+yaad00DuJ+agPEpI2BVmo5SADM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022HxdqE5j8+BoEcMgCrzctWA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022c33653e44ccaddce6c5d752d1d067eed7d8d6bcf796a9799bae7ca0ea430e2f1\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/6\\\/e008759.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/6\\\/e008759.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008759\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008759\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008759\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}