{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022ixY8Y63uWXYOuiuFuyLMiy4YJobQeQePkV5qndj\\\\\\\\\\\\\\\/qVqF7TOp6QNUZ1GHDcI7GmsaKHJsd4lk0aGDK7UoC0tP7sLrgLl89Cp0zFytNS65QxkBz3C1nFtr5vOAZZwc0rgTXdAJPXtm4tp5Kog800FONdJaJvRg8oL66HV\\\\\\\\\\\\\\\/nZs57VI+ydc80+3qjMOlfaSU++CIml5ixNsLm0QS5phZFlxWwePA1WZiAHe1w9gXEMRgMVvjUjTlJvTE4o\\\\\\\\\\\\\\\/1nST5pVF+hH3h+Tm1ayIbkIvKBtHwtQSU66jpnKh8\\\\\\\\\\\\\\\/kmvdiL0phKVw7cjmSXIUZzR3aFuMJGZVewU6kf4sJipb9GQlrcR0LTjicgXTOIqPWRwmH5uZJreuvROY46qHyhgZ2Nb747\\\\\\\\\\\\\\\/ycD8uAlnRk+vbuXeFK3EClSBoLfB76pu1b9JxYJD6GrBt9t6akVRiXiWsjOESs2NpPfdhGnciAt3XZtL1MoKrcy5SpY\\\\\\\\\\\\\\\/xVilCfMqg9XFCF4gOTc\\\\\\\\\\\\\\\/dQOWSWICXOZ\\\\\\\\\\\\\\\/7ZCdjvuLWVzGzRdeqVVhUyNlaY0LZ8jwuUXnBhvyHKjUB4xpsCAwtwoJA3Rn\\\\\\\\\\\\\\\/78KuFfPQiMemHWUrH7glbOMRRtQY3jI0MiF8LavF3JiUHdNQMalP79CnnsRR0\\\\\\\\\\\\\\\/DlAyMXSbda1c2Fz8R0Hv+7jw0TmUFAhS4j27Giy2Vc5RdwX0N5kFrfdZX2XEIQLTnF8i5v4grx3Nu2NJK0sBopEThTxoNesmKW1nVTrXIGfcB6yjXDYEKdt95lE8Gc6Avw3owcnk3ffA1R8QgIv9OEBv6r\\\\\\\\\\\\\\\/gKpRZUN8a2pjHdEVH2BVmCzRfvvX78wH5OcDEygP+Ls4Wy80x+Ixljiu7KG1ibC6URGmbYmEPpXV+9Xo6Q3ECGNIHqIGOdrIm4GgssG9l4sqKPGbhFxu3s6LNBzbtHsScLBL9vZvcPe1y\\\\\\\\\\\\\\\/dywq+Ozji8V83K6UQubz2f7JtfgKMAr+Pd8\\\\\\\\\\\\\\\/EQhbgRoEc6SE\\\\\\\\\\\\\\\/aTB1gcG+\\\\\\\\\\\\\\\/FutsprOqVI\\\\\\\\\\\\\\\/14DaF4Th3dT0\\\\\\\\\\\\\\\/+X+96jb4CVohgePFCeWnsprhMZg1\\\\\\\\\\\\\\\/WKjXfbeRWEdmXpTVbCv68T089+5xA2Vs5hjKahYCVWcRsrgwWs6dlMserOSg36N8ZXq99rwZMW+zq2mHrL3XRmiLnQn5xb9d3RbYpiQ1LK1TaWUpG3+9AnlZUnzro+3w\\\\\\\\\\\\\\\/kWRS8whuI8IDmFnrGV3qJUXCFnF1cPr7X6rcAm3Xq+ndUNEH286DXf2R7Zn0K8g9aw2dVG+rbSQ\\\\\\\\\\\\\\\/pvFuPgpH9nUicCsynTZ+MrOhjJsSulITAwvLUhk7VmDyTkFWY5p0z8+sM82nm7pAokI1moZ\\\\\\\\\\\\\\\/bsYAEIML67HHrr6A0uE7Xq\\\\\\\\\\\\\\\/w5XyEKgR4P6WQYNZRmnWs\\\\\\\\\\\\\\\/6VkAzeTq+E\\\\\\\\\\\\\\\/AAP7esOukUPoMIQhKruaM1F7JbI1of0iyun3pJ\\\\\\\\\\\\\\\/39RtTkaaWKzvGS536J4gU8+eEDrxlxGqi+xkLd0caNK9nAgd9qPRww75ZPOGLGMziyNOwH3hj9yDC9XIjv5Dg87XsGXUT8RY9nycPIbnXTlV9aZxeTIU+l44I9oT\\\\\\\\\\\\\\\/TflgOVppEuqCTETUznq6Wx4UsUQQQiPG9pq3BS2MrjWwEV+vZE9Mg\\\\\\\\\\\\\\\/IT60WUf18lattF1hbf\\\\\\\\\\\\\\\/CMcLA3bA60MXNL5b\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/LHa85JTaWAr6Znu61XBtS5IGtFlqvzfU9KxZdKnPGHKK+bYuEVUhvGEhU4V6yX\\\\\\\\\\\\\\\/TxB043CDImVbjLCfUTIB\\\\\\\\\\\\\\\/NZ49nL4x23bLu\\\\\\\\\\\\\\\/HvB2H\\\\\\\\\\\\\\\/iadM7F1ijTWqDOiu+CuACiOA3A4HpBjs3P4erjPA\\\\\\\\\\\\\\\/VuzPFkaE6JjXj5s0joxUe8VfqmtQtAewW0YVv4zS+QV6a2QX3n6pvafIvXUiwhxBZChRanjQk1H9KElv3KLBiJMWxatqG5uUTUOpUPCPaUkNMlkw3wfnZb6qGOPZwxATns4td2E2jKO7EWMXRygi6\\\\\\\\\\\\\\\/U9QTcsNvUFamrttfeBAbnOT1cqld+A6lRdtFEpP5ms9udXeBAfp4\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/Qi7dVqksFxqRxQ5NQSzv2IBvEo3ddLBvTop0PGNR7SsYNHy01D7IBOUpEpzKKPU46WDJeGK+FJ+HjQJpurq6LF43qlKyaySc0OYAB3eNBqS2DIMKq7hPb0+BbgC2W8aTuictO4cqQjxMWu\\\\\\\\\\\\\\\/ypGSEmSagpEECSoLBCm\\\\\\\\\\\\\\\/OKQRRlLTIarUeyetYW3M9Ukcs5V4WP3mfU+wNYbMA7OAYBqmzLrmzdWAGu\\\\\\\\\\\\\\\/sWB7FPX8TU3wZILnGrEWtX\\\\\\\\\\\\\\\/LzIaNthurYFR1Pl1dyQ3WcOFGA6VUjVVCovnkybxlsqY\\\\\\\\\\\\\\\/bOEfti2Uoo2PDsh3gmmbSNlrc259tPmuiRFgohdbQYo5i2Ah2xBkaZ3hzjTnSxBSHIIQdVlXjE8rsEH0n8hoKUgWwnQNjfbTt4tUEKCXjT7H9c7yf8P4rQhJEpj+M\\\\\\\\\\\\\\\/VnzRELZXvoe5ce1gX8rGzbGMyCIkxBawBQuImTOJpw7JcE8Ru2sbsmnfiDZG0zoc2kKRJa9vCL+7QpRQ6Bhs2rhq8jbbdwJsWS8QxMOFRWRjuSElqyORJnLZzFog8JWXAx+U3GpwwskyVxSGWEJie6tT17tANzhmAPSsqJBpbKVV5SXoe\\\\\\\\\\\\\\\/xTP+sgxwlpeKuYOxoaJdji28ubkrITLTo=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022mNtzGBiHjplrnzy9xg5Vqw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00220bc2c435076678de23cb0c682d32c0b667b8c7538dcbaa0b1a69896b85915814\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/6\\\/e008475.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/6\\\/e008475.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008475\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008475\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008475\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}