{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Lwtx7Hsx3IrIOttU4Pzdp\\\\\\\\\\\\\\\/rmuTR7sj19\\\\\\\\\\\\\\\/AzYWY3c6oxZ3ceGiammeJgKZNkf9dRPzW7Cnq8itGA6SUQesuygI1i1vjtq5B+pnPZ7SOdaLt86V5QN954UxWEuLyYj8p4+t8Ec+PNpsxesWoLi5jqXGdObgGGZ\\\\\\\\\\\\\\\/AnvWuj8WG51jzUjuTbDoMBhFlaDkTVVwF9zWxyEoCS5CbCo2szdSp6Ux0EH9pDy9zWlw0rNSsbdNZEIg8zPSZJVeVAEQb5WiYDNAEYAWIChAupB4GX40\\\\\\\\\\\\\\\/KH9FUVqlS8SUEN3Lxq5\\\\\\\\\\\\\\\/VLU1VpIhk0mOtUn27l3KirsV9MB\\\\\\\\\\\\\\\/gDm1hVyHZuisLwbMEcr8cfZFNujctat288Sjlg8k+hITycnpjEIBvLX9ZWJXXzv2VsUfhlbDkIBnU7IoQwzzLtSiA9IMYjyOoE2S3QJa7CSwHrHhOndNE41hgs5w6\\\\\\\\\\\\\\\/ifrPKB9rCQwTEW8UHJAVkFxveiedWvNO7NQd5aWzVwOCbdD8EWSXJ4\\\\\\\\\\\\\\\/r63gqUd9g+5d8Lx0lJETJoQpWlV0KnLTkQXsvh7Yutt+zCor9sy3r+sxDtNRbmvQ51YjvpWGHrcLNJRYFhjKa7a6i8X6NbzbvfPZlrNJtZB\\\\\\\\\\\\\\\/cMHs5686j7kDPkSeHBLfRfuXJFtlrVCKFxVgUGdb\\\\\\\\\\\\\\\/+oJCW79w+s4iYaKJyeR+5D5eHCnHCkAYPxZGjBe8fFM72ShibRn59Q4txZf+SqKc4nke76CgjZYtHCQ9PXmedMsVQcaIF1bd0EGpUO4v7szu6APmOZsz7YnotqgMoGpUQhH4M1mduIAS84QpKHxfz8tlhRtSM5JfWD5MAhfu6zwBCrX8CE6yhDQOUVadt2daDM3xLDNuUylz5yyY\\\\\\\\\\\\\\\/+lpUGCaYv7ipzHc4e5OG7bs+EhzD5Gk+bmDGq75ANQSiXl+BoGKmNEkZdDn87avFlkf4Eg0o4aACgM0J3DPSMLzC0ZpBwzPGR04epNHgd2qkhubUmyVCJ+uvTlZ6dwHP6sgvyg1WlG5Y3P0NS7PYvvNjE1u\\\\\\\\\\\\\\\/Ro3nLl54nlnqL2TyeYiMquFYJ\\\\\\\\\\\\\\\/AwFQCtrR\\\\\\\\\\\\\\\/SkT5Ah24oAalFXIUYuma174x+QfCGCT7C98FsXBv5HSN4MpzYFq5O0vYNLgm5oDTcJSQaU05FwUCefLtDTha0tlwhMoeulY3rGRncI8VvK6oqjQTN6I0pWP\\\\\\\\\\\\\\\/wyfztZJNd64e75BlxwH3e1neP9twYMnHqxNOpIF\\\\\\\\\\\\\\\/92H684CCYVXLKmzrSY4gxL1EQq2MrvfhIU1e+7aa2ZTxhXKg4EPz622tLtqCQd0yRe9uRATkJlap1BLWa\\\\\\\\\\\\\\\/n6NND7VD5hf5AbJq1IgS\\\\\\\\\\\\\\\/0YCBCxG6uTr\\\\\\\\\\\\\\\/gZb8loiZ1aljKDM3pDptQoxwMAUcJCZ7WtCcg\\\\\\\\\\\\\\\/4rtqSnxQ6h7HWwD7T8zsE9TvFbr8Z+6Br\\\\\\\\\\\\\\\/CLCHAZ8WZqzRpCFlgt5KHOIlGKZ+0csts9ljDh2Xl2+jgXK4yRM\\\\\\\\\\\\\\\/xD3AtxY8YOFAjBLd0RGj8\\\\\\\\\\\\\\\/wcVOE3HxnRZvvyNYipBDqIlWoPjyKHsYHlErrOKLaaZlTBt8woXkaZW88KXuCSRGpEk+VAiUcv0lKPk9zRr5IJjVkY+67TbbtDKDGS9s4StrchlL+sXBOJ+83rlG5yCOMOlTK7qmZ2fcR6QPx2zRUM70QnjgMfcFv\\\\\\\\\\\\\\\/loCzjuoEEPMyunKQGSxT1z\\\\\\\\\\\\\\\/CQ8aOeAIR2ciWMzZG3AeXkLSMWFSFOJXiV24+bKD79cvACY0imMPrzcd47PVKrCOhcoXmhlx51ud\\\\\\\\\\\\\\\/H7STsygiPfLDl8Z7KYt3j0KGt3RtQdxRrjyof1tXhjufHjp++LcAnavaSueqWwkriJ1lY4RwuGP49OA06WbKJYDGNAdAMLLeDNf1z5QmFr+8wLK+t4O5kGTrYu4n1xkvNB8M0ikLS0zm7JfTCsZ7rT40Sz4mph9LMbwv2t+x06X2eYgFJN+YoFbZ6jLnAMgcCwDfMfSdeTFLh4KQUlqaEpJLi9OY2x+joq05KIQj7146yRmnmZ6rnS9zs1S9Ub18V78mmQsqGOwmb8MIn\\\\\\\\\\\\\\\/W7FbeDCK92hW3eQ7ufLKnW2sb4Dkg\\\\\\\\\\\\\\\/Xq1ca+aqwn+\\\\\\\\\\\\\\\/+LK003nA+D0R7oWQ+uKB4Fa6oGLSWloets5ivssGLsriFSdXj75QJoJCWHuhVI6YtO+vjCEr6Ud4YXCSLayLMANQciHXM\\\\\\\\\\\\\\\/V3r33JLgEAjpV5fGImzTTPCAX\\\\\\\\\\\\\\\/i6tTWzDioVyk5DaQigTNHwvAmBwxowy3cxo1aj2OsY7dz1G9zevvVlBUzvMkLgmTuXu89ZzkkbF3vaYAgz7bqRM\\\\\\\\\\\\\\\/YoiVlIho6zehe\\\\\\\\\\\\\\\/Rbc7K0c+Iu87BI7FnKr\\\\\\\\\\\\\\\/y0kqEVmq+gyLHhETz6QOf02+8z3kG0yruXs3mfu7K5HOKVMhVHrq+V7Lm050OvMdITlpvxcin\\\\\\\\\\\\\\\/sajeY2E3jHv8DIUzC\\\\\\\\\\\\\\\/ZIoVfho4QR7rGi4\\\\\\\\\\\\\\\/ImRRRjPIZzBfJeM6u1Nsy0fSplTtltk+hTQyNwiEWntMXUHC8VEPt44DjpUOw+3la4z5IIsMqNyRE8SGZgk1Bd3GDQoZq1wu1DrGavdbFoUciv\\\\\\\\\\\\\\\/PT+XOnt2Nb8Qrh1l1EWR4n2h27OQdEq+8twem8e7d7t1vmQkJGp6gjdvaZsc3kxJygRJbTFb+fNfHc6NjwhAXCKb5DQ=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022dBhDFurLF\\\\\\\\\\\\\\\/2lCpDfGEwB9Q==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022f0dafc7be23fb01bb60a2f2cf15b9af372cf6a722be8f0ab5fedd24141bd16aa\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/6\\\/e008667.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/6\\\/e008667.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008667\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008667\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008667\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}