{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022jYsbt18WvPQOdWQzvemGeNSRocGIn77HA2h9LduEgeO5YFW9e0HEOkDNTioW9q7tIBu7Mo6hTnSiutscd9IeD1cq4g6Y7Ah8hOa9aImjlYOXNEdBX6q7JW3aG7O+a4xKmUF15XYlZevlDYYdwQx80eAQPjTrdfpv7Kq7aIeP5\\\\\\\\\\\\\\\/PRPpjbEWgckdlahWqGnGQhFwAI0EwVDKd43t2BUz\\\\\\\\\\\\\\\/Dau+wrEWn+dM8ohA050k4RHgMfDpWF7SYergqcw7IOwrA51b8US8Yym\\\\\\\\\\\\\\\/XuRYo2FNHACi7A41T7TcRIUHJRRYApijgpAr1TXFAuvSHdPKQ6jgXk0BGf2jZ7AUhnzpELuQ8dWc0nv6e59gBbV\\\\\\\\\\\\\\\/u4wD\\\\\\\\\\\\\\\/T2GmfpUzVa725xRnUrxg7TTKnlLmXKjMbhjozMvvfIt22Vh96RcwUKuLuMMT8ZTmbSgT7WW9Q92pHdvRsoD+Txc+9j30qLrpGhGi3jR41k79LDh9eknvtc8hIbM1+TYJlLogCnhpfrDN4jWWowZv\\\\\\\\\\\\\\\/mdfUOmNYZJoK4LvNPPgoBpI+oZJCWqlnTlEC0lhgvQ7tr+C2PG5J2UZdCNqZ8vAG1CvAmiBraZ0HdTvdW7jgeE+8GYfB0gSk\\\\\\\\\\\\\\\/Himt\\\\\\\\\\\\\\\/4vf35Ex5D8Dk5k5H4a5YJF7kzga2sMb\\\\\\\\\\\\\\\/YYFa8Sooa5Kftgd0Qi5zOrPA96SPHrW5P8oz6fMtrD4WVIKLJD2FyV81Q1pCU7gnCcD7SDZXRcYupTQ+r6opaKrKyqmLvTwUzt535GS6Y0R3KCsMmpeGvbdmUuZVTZ9bIlWaZsKoT\\\\\\\\\\\\\\\/dq0fgjhA1C8Q9w07DoHoLZw6ZV9+Tax8NklM5O3kHbFgqMeVZtuVjjJq1cfj79v3YU5iaTSyeYradltgSa1J2i+2Qld1ds4KeE0w7az4o08DOx+7hNs0TxT1+\\\\\\\\\\\\\\\/kwEiB2sLWLJFi9yoOf2I34X5xzIaEScpnJTtbtW\\\\\\\\\\\\\\\/58cbm6jGWogs+qmHTD1fZCvIK8JZnV8+QwWdLYkzK3rJumQ7WfV+pHl2PcklGGSK1tOgcyzjRevewZehcJtTFFb9YP8FQAv2LcvGnLvGDRegCRBADc4d8Rou0Y5dWI9Pj5a3Vd7CVsrAvHMgZSfIqxugKQwHJDeeBCPYkuZqGYI8ZZE6ZGZQtF0719\\\\\\\\\\\\\\\/zbMqVTl9784\\\\\\\\\\\\\\\/LBZMRREUCTtMoSgbVMFRXlrxNj1VGxUzlju9owriTk03HVl0PDcLO7Je\\\\\\\\\\\\\\\/vPWYHiahEicXAde3kt5bl5CTMSBQ22AQJyJHAVNhNAvK8mMVjVlDjwIaYdMbmMyglOe6stnRhw1rJa7zunn5lmEPKLCbt4mlAoLWGjhgtnNVee6CS9CeqopY+oJDEhapJ8U4gJSAAplAsuYwusGIElpgWGOYhNkJNC58GZz9qhwFkXW+gGNbHCYaQ3qHAs\\\\\\\\\\\\\\\/R0IF311ChiXZ8c+uT2Le4MMYAXnegeNa1q2R4qqStH3hABd7au5tIkfa+c6WLGDroXo3Ly\\\\\\\\\\\\\\\/lmzGLSZNriUOtDmkz5ZGUJV9Y+76etydYF95fwH9brePf7dalw0z4SH0GDyYmZM67PD8poNUTLQUrIc2Dhx98HRlqDqt3KxPCR3+BHyu3u+27L0u+1M26C0krCEw+cS7PnqEW8SAyQPxITQL9\\\\\\\\\\\\\\\/7VTwxhReIn9EG9mGhBm8QDAwEwxXJQpQgxas4muKk8iBr4fGerGFAKHzPOAyiY\\\\\\\\\\\\\\\/kw0szLIBV+fCPgrDCzDzZ7HtFMiLvr\\\\\\\\\\\\\\\/0EDVU7mY3MNzOIZ4f1MP77jWosYBH5Th0ciTZUkF9d0QfLZdpTQY5lEu4xFpv\\\\\\\\\\\\\\\/faCGfUgu9UcMGPTwTx69RING\\\\\\\\\\\\\\\/0ypkj1OIHmEPoENqIex1t+gee0d0BMMG\\\\\\\\\\\\\\\/JyG7N\\\\\\\\\\\\\\\/0psD2od0E8G+Oa9Wv\\\\\\\\\\\\\\\/R0pi71NHIveBgHmqGWmUZ0ytIr1oIK4kiDobMWtaCPk\\\\\\\\\\\\\\\/VnqMpLHH50Sfat1a7sxKl89OpbgWBom6qa6PEfO4nc\\\\\\\\\\\\\\\/PKORQj0Z5fRebEmMrrfcF4KkDc2LRkQcLZTFE7G3CYT7LjnvrjtDVPEu5UG8t4UXCId5kaR4NEQWk5mbYERjOrrHsYsxGIpXTmGT9zboCvIH5oTSuLL1HeFklrHOCQ83X81SdmR5Ok35sYZhdYW8pBbBseM9o++7UZi85zphAEkDMZBJlYD4fdXKJyoPQrK+JbLQRIJpJjJt1Uf\\\\\\\\\\\\\\\/B0fWf5vuOdga7\\\\\\\\\\\\\\\/O3GadMsoBUxDVeiWMTvIkpraeJlG4z6ktlJIaNuJeWNGuZiCNNxs3Ppl\\\\\\\\\\\\\\\/m1oNmJm1lfjQ7HAyvPcCJTsB6Ilq2l8hdjDnFDx+lGTLYLb2vF8S76a4wxruzWlZkz\\\\\\\\\\\\\\\/+ptP9\\\\\\\\\\\\\\\/VPqVsiqHxmO9S99atYRGWvHRSa+2AjBgUroOZuihRUv8SSqifk60SVcVfBaqIDHDAqwtXH1cJ9GIaVnVUkjcGvfkUOH65ciPj\\\\\\\\\\\\\\\/ewOcXpwXryBzj6wTYW3W0Z2zErCEdG\\\\\\\\\\\\\\\/PdOTvoUQshtxspXpYFjBZEavTF9G9iw1eEuu45OpptYj4RFYFeh1Xdj5INNfxoxD+kbMp\\\\\\\\\\\\\\\/SgjHPWEat50orq3NIkvo0OU+BS\\\\\\\\\\\\\\\/tR+9Ph98kzNWpZ3yrYV6mUoL4TTnAzeOFvBSE8LvHvMV4yuWwq5mJxlNepC8IMupfYStHYRe4zV6\\\\\\\\\\\\\\\/zLkqYzSQWEZ7Hxew=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022H9e45JYb0ZW708ms2hkavg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00221f0d0cbca8e3638b755548c204fd4e17664b1045f6a8b5d0e36f53bc481ac6d0\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/6\\\/e008733.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/6\\\/e008733.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008733\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008733\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008733\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}