{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022ltJVY7Vs1dFfMyAC+gQ+ju0jIX6xBoVUfCPFL0NPeVwrv4GyY2guC7gLVeO4nWUFKC\\\\\\\\\\\\\\\/tY3EUgInGOV7IqoKguNpx55UzfWlHN8n7l5b8DdzPtqxiwsvhw3wRnLStqIXXELffaFCRuSRY9XXu9i90Idz00igwPTyxUhgqV1MYbGq3K+j1j95z\\\\\\\\\\\\\\\/jllclGdgWlS4nYgvtR+qQ6HCg25W6p7mmZmWkRRsBLDDXi+UeHdTYKlAJfHcuWTKvM63So4qgs\\\\\\\\\\\\\\\/05MsrNf6KplyKufgT5RLdBeWvHk8LrmUBjJu5KH3Ka4M16\\\\\\\\\\\\\\\/d\\\\\\\\\\\\\\\/5Md268UesipViB0OxVVFHYEZRRBrnzVVRGiMiQX5n8VwbOZe6J5WvXdNeoaxVjZbYtHRA3Bi9ARoU2t0OpaOe+eJ9iCEuC+Gwep8nHYMQgM47ij19o5QINwI0ITXPFMcuv0NousFPv4+Z3XuQ2LQkLqGFOOL1B81yM8XvmQWeceY37mwKC5dRWLUVmYxghwLglkKXA6ZS3ceW1wcyBnchpO57uNGDxYDhFbizIZmewsq+B2TuuIHTusKeDwaBaNHo5fy0d6esPN8h\\\\\\\\\\\\\\\/VNbniVokNKMBxfTJs5fDN5EtARjoVjEjfJwN+vXlYsB3uch3IOoXAZ0d81PAoKjAKGp9wBKBw6iOT\\\\\\\\\\\\\\\/JOR0lqyHOhLjgYGahJYgQIiYg\\\\\\\\\\\\\\\/zdpMoWUG2JSwmAmNaYbG8w0CBAdLb4MvFID98DfMUdIkmwDECQqUfzO8I2W78p27EgpR8eybaItz\\\\\\\\\\\\\\\/7IHxP44wg6RDXdS0zp3fjmL846J0EduQLPNf5MWk0Zkj7Fn0ZPfjLT5nuS4l\\\\\\\\\\\\\\\/dHtVSXW7KS8bVLa4QPOgSl49LE7tKn4yZ8ucUfNOahas0s1jqO9HaYraBEvrXJHO2Q75cLOensza2cOL4\\\\\\\\\\\\\\\/UnowwMKASPL\\\\\\\\\\\\\\\/ybiUdmyiR6MzIJxtfYGmejb\\\\\\\\\\\\\\\/aGNkEgb0bJTv+QipfHkjLD7uoiZpKnoWt07SuulJamSzEO7ay4EtYkffZuQqMLoyOcwHUaWiiFu4RsG2i0BS5oc+vUTd49cFeku9oqVUIBWzzu3gLl16FlrWUsbttNljtB+w2YGPWwlOidmQwwW8ANOXnTN0aZjxAfsQ30Q9HqL79Fq2s0Z+s25+2Qu6qhcbKDr51HR1tuxxhfz\\\\\\\\\\\\\\\/zI5mayzHLcQaCg9IDAUB\\\\\\\\\\\\\\\/sq\\\\\\\\\\\\\\\/EZ78U+mc7jHcMK4SjSXf3OBmtEdZUP7Ho1Cl8+lAQUQerh2jKyfxW9dRiRxQ4d+3NG8LwLHBvGr\\\\\\\\\\\\\\\/gEHP74f3AbTRXXdgszCE3EQJPzeAow6ZAeqkA5k4hN8NswHCb16hhimTgM1MXNSpOe7HfncGDgy\\\\\\\\\\\\\\\/LJX9bCTGFDidruxTJ8a+6i93963+VlboiX33lMPzWIx+eLFK8Ccz6C9Lksgd6fJz1YtQKhuZWRzzcbsmryjZmpsDd8RPQ2jtwUmoLDEIc\\\\\\\\\\\\\\\/DlWFLxfoUG6PzHXrUTmX4iIf1TnFFn9cc0ARf+KygKA6YnuZ6zlN5j8AAA2ZRD1W3mdIaqRaSlVQwLYlXNuEcEjlYV2A5CIEANp4u\\\\\\\\\\\\\\\/2jso8e2EPFqnUBmHljJgLmZqNiGnkCa9J6vT\\\\\\\\\\\\\\\/osnuo6Hh7mTNvkDu4RSoOxnPvZg0hwGt60aVAd+C6I7mCg+180uRlrk6Lo3LTuH7uK8oxBSEK7tTo8aySyPBWywu5EVTMmSk16N0Ka6nyC9uU9UwDdNIfs78AkbF44S+5cmTRE\\\\\\\\\\\\\\\/YZhD6GJ9t33RkXjPU+e8rlHMSkbIsSDcSUhoA4kHdVnEWWlNyAxG04WKHOYz6BPALVgg\\\\\\\\\\\\\\\/2zT+sQslW72yp1j6QOSeYf9MEPRSFZa6O41Xbcp11L7NZlhOneWRu40zfmPJdHuHF+9g8FJcoDxAlSk\\\\\\\\\\\\\\\/xSNfI7Z4OeTDfMbKl7qEbFGtYKpiRKy74zmyQGwXJ\\\\\\\\\\\\\\\/GmtoKLLa6PaeyjrOdhZloPD9VfOUHy8Kq+\\\\\\\\\\\\\\\/1ol7W5OPHYCVQ\\\\\\\\\\\\\\\/jFGNHm34zdk07\\\\\\\\\\\\\\\/imXlCrJ8dcAIsEyv5al98yR3QQ35hAuQc3T4HFAM3VhubQR3VzreJYQTWRgWem85ZQMCH8gudHQyyPFjIi49y42ctjyzC\\\\\\\\\\\\\\\/ECr9ORGsH9FIodb2lT\\\\\\\\\\\\\\\/02e8ijCdfW5uUD6CD6lkAjqPp6h2KtYlygVlZQucY2gZH189OaC\\\\\\\\\\\\\\\/C7nR+TR\\\\\\\\\\\\\\\/KkPOQUt\\\\\\\\\\\\\\\/GtLDym+eqwEi0jjJkalP1bzSnP78GVD7a+KGrihsI2eqiNdNt2N5fUeYeSEYJqlH51bIrqC2CqewoWwAHH4TzSrOhK64w0t5vL28R4tQBckRtndt1G6LS\\\\\\\\\\\\\\\/HF7bmltBxXxXNGZcBo+1mO5wfcS8AlcCyYHXL5Il7KuoU\\\\\\\\\\\\\\\/c9iHaxv8pneB4hlutSyI5mEtCiNb0i2NXSgVQQqZnPITz48jrIOJPXhMqUnvadgkD6WWqAcPKFSG0VwHSG+nu61eIWVY8N7HdNOdsNwg7h22fKI0mlzZK4hhnLMmQ89voYp2kO7EgNgAbF\\\\\\\\\\\\\\\/oBHiQGs6pj4UPFzB80bILPZ8CIjana0F0TiSBcCfuID+XnYQ6f86vRwhfSkDdrnDhh47na5iavE7tGh2rT25JRbVFhyLQteyV6ml8ji2D+tw7fd6nkC9cbZIBTbHOxgAO0N5uvugCP7hy+Jek5so\\\\\\\\\\\\\\\/EpoyvS\\\\\\\\\\\\\\\/ikEbu0=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022T23HoKRTzeiI+jHJLJhkpA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00228689b844f99131ce0ad26b8da6ad44cd3b7dd72cf41586f229b081682bb4c20e\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/5\\\/e008589.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/5\\\/e008589.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008589\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008589\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008589\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}