{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u002289rMVjQI\\\\\\\\\\\\\\\/swHJY4dW5V5VK0GovOS8B04jb6NLepKdb2Z0ifFaWVkr776ourRZ+ORGpwW\\\\\\\\\\\\\\\/EsPaACtp9N4GDTI0tvHPHTNu4iNiPcMI\\\\\\\\\\\\\\\/M67aeI1gG8PzJI6B24lprMBmFhzZaxFLYX5ZwdVg3Dl\\\\\\\\\\\\\\\/Hy0sUr539VFUA\\\\\\\\\\\\\\\/x6SVzqWR80tV3jyTucSKTTxwqOXJoLmCRMqCV4BO53OE1b+Rr\\\\\\\\\\\\\\\/hIlkFAPG2m70U\\\\\\\\\\\\\\\/kt9EQr3jXN3JA2Eat23eJRUFsDAqfzvy2tItA1dSk\\\\\\\\\\\\\\\/Un0DYIIV6yE35gAWHGjilSW7BQhkW50AwmP5l3+A+t4cusKu0cm3idkTJTIAqluyXMMYFEPJ1qm8hti+Lg9OVMIOkCsr7uaj5bahSIludqPE43U1PWNARVl1C4CEzNa5mkcKJJUkRXQy5\\\\\\\\\\\\\\\/ZXHNrDByPeTe+TZ73LiYtJxeLIFUZpOc50hnbYrADNd4zgN68\\\\\\\\\\\\\\\/GwuESh6PxEnxj41jena\\\\\\\\\\\\\\\/PGl+nq13DHsgkPMa+TxOmlngZsyM79wiBeyrX2PGRkug+mArA2wdwsO\\\\\\\\\\\\\\\/udesEm0JUFoJ4eyCV5JU1I8495Gp3Di4t+zZS1emrl02Iac1dBfZmXA+lzEJD1C8ETcj8rPfXqvgh\\\\\\\\\\\\\\\/8oWcUc3cEH5HC9b\\\\\\\\\\\\\\\/TW1OZCHUcKPw9Xq9Zfk+AzzSPl\\\\\\\\\\\\\\\/xA7ipP+Q6eDlLj0WFlgXCPESptpQIKw1YAMGPJeR0np74QvcQWxZThfCQ3j5w3LbLXQsh0FQfC+F1f6f2Jjs\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/oVgtO1QkWA2ZkV82j2Tkt0GEOOjGgnc17hcDL9DFzs+5N\\\\\\\\\\\\\\\/h0BXJ6S2dx3uMRGyEzOOT6sFfoTz3f4EMw1+uC7x5ngIhpD28+YqBeVsFkK85cZoFvOrfYo0lJqjXIdTtIW7ATDs\\\\\\\\\\\\\\\/sRmjUJ8gk9n5rd1GhsdWQOFgm2pDM+P506E\\\\\\\\\\\\\\\/jMxd88OydZxes7SnjMfTzh1A9PPKj2rSqCymrZMrRoYR31fXinqe6XslDKfJJqOXqcMVQAyKfgj5FhLky52oaFRTA+0\\\\\\\\\\\\\\\/f5MmG1QQjRd3PEokffq9jP9yfb5bCOXo8dk8h7NhiJqI4k1jpuIu0gtKDPKlEiCiaPGGurGGtTglGLX\\\\\\\\\\\\\\\/qErEz\\\\\\\\\\\\\\\/LMZgEat3kNaoWIW4\\\\\\\\\\\\\\\/fPM0FzVtBfUBv\\\\\\\\\\\\\\\/xka0Lxhw1+SN0nwuTHNX0M5fvplcfUihPn+x3LbGfehO5ts87fSAY5TdxrvjY7iUF9ICSlgZP8MWHONCpb9tya2sz3P7uRmdZUOMsATt9cKU6aWBpbdhXlnfvUIg8EUxpzCihCtlgHs4zEl6KRBAXhJRJPI6YYIY9D83G8LnKkdJqzbh33oRGz\\\\\\\\\\\\\\\/yg1Z6uBzd0y65N7ZCtOupVXRvnkjO\\\\\\\\\\\\\\\/wGGOm2HydnvY8\\\\\\\\\\\\\\\/EoghJppTdOBYBWVap\\\\\\\\\\\\\\\/UUY\\\\\\\\\\\\\\\/5polbRl5HdwTYFRQB7ZulbUhQ0Q5XC+6+\\\\\\\\\\\\\\\/gszf+l1XrXiDq7bc6a8d+4Lv\\\\\\\\\\\\\\\/EQlRtsyDXKtTbWo+P6g9JT66fMe2TBOQ149+Nk9Ju0vDt4LPCiLTNJQg0blEnVVRoVTfgNzgftTxbU1SwnslGajd+CoZcRfnms6byntS54yvMg7cjfTERsUgM+iZN3f2eeHuveZfE0Fhni3jtlhJXSHi\\\\\\\\\\\\\\\/ZnMa6aQhZQIrbSuBOfhiY5MioecEPSf8da\\\\\\\\\\\\\\\/mZDITZFGKHPfcMYcZD0F2MQTritISm0nwGKJRH2y3IZosfKb6tIzDgjxspk9WEfPA9HcN6AKotwef+HOJONJTcD6Vhbb+5YGhfIvEj87TmR7bToi7nNzjzSV1BTmZ6eMCOaugCHtuKZRPKDNjDmGEUixgY\\\\\\\\\\\\\\\/yv2iQU0IntCsgFUVhFFO8lVBbfH3zCBaQU6bqeA93t8mTo4W7tEXjbuhWOuOzsB3H+EvW4dGoydF4zIuZrfu3ECdAyXBaCXy4y557g4wTg8S6v3tVVJGbAT2dE2N7MaAOWz0uBAdNwFS87BUpcBraqhV2CzFXTlmXKBQuqm+90lW3njTw55zAN1RxdFwifKO4jGYDMGqmsxOqpWAHkVSlcm6TZERnOhAZMaGr1Za2+wbIHhRgCbMVr+K0YS0lAiTEe2ZnlMyUnfaskZFhVpp1Jqea+0p\\\\\\\\\\\\\\\/wPaXm6m5BfvXeJyNhC1nN9f5M1qIJi6l3o6fjSCDBEbQNLaLi8vaEsicDxeBTV7AYVdPfQBV23XeQkJL7NeHNHfx9Kpxcg3d2bt8okkJVhenwMhZFeFDKxycVulfaPkTyC2GAEoaHDetP2R4XhyhneZm6YmQ4NUxLHiLxO6izzB\\\\\\\\\\\\\\\/GAGLFIKnN8sGjhy9iXInHfix3sW1pNvOsmaptE1FpFOrO7+JvuCKL\\\\\\\\\\\\\\\/Ldj3AwL71jRQFq\\\\\\\\\\\\\\\/5NFQ6o+ywAb8TSO644FaZ5eionVvDyHJ7Iugjl0cQycBLvryH2Bl6Cc1qNR9wNRGfTH7fNwY7O6qf90H62zQ9LBgP7x1NMEofyRZNTtWGhXEu7v0Ru2bkE1wwjTn\\\\\\\\\\\\\\\/tAZ8z27q6FJwrTv\\\\\\\\\\\\\\\/VCHBZCKppsL5LHkExDNOIONGRz0MQ9uRw4ksqOTKOcAjGIX2swAFNFv0RVRo4wFTJk5gllv0AWIZYMcu89FaePcynR5cQsc6NDsVpM5\\\\\\\\\\\\\\\/G94I7M8vx+wHzxBNUIe8jdnidIKaeKgw29VHJN2coMCp2QBzyRjb8o\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/TRcs=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00225zRUHKbEeZgzlAa+lQmtpA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022d4abe5086f6b62832404be1ee6a0c78d66c8afcc6222f950c8419ae92a92793a\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/5\\\/e004113corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/5\\\/e004113corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;12\\\/5\\\/e004113corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-004113corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-004113corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-004113corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}