{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022ymJHT\\\\\\\\\\\\\\\/cEu0NbrwEh2dFWrB4RxNrAkBT9TJpGN47rRDGjAVifj80rMvMh3hOXITZa1o013qus81GJ2yUIU7gYH63eLpiLcrsQC2\\\\\\\\\\\\\\\/gTux4PguZ0lrYk\\\\\\\\\\\\\\\/mGJNbImEICByqBjAJeNdtQExIuBwSoldWWRNGapZWQsu59p+qYCAe1z2gmU6os4hGuuIc1aove2xkh9OtX9FEVI9bPCE7h+8HO+Yp2ZB8CRxyP0fBnjLqgfrxKLw5XuzJjuQd8995uhlWDhHHx1UPRh0k1Zv6stJ3VXMORXoTlyFFGB+Ee9OZgGpNZFGEtNf7Uq2ZPWnl\\\\\\\\\\\\\\\/3yD+nTXEZP5iX1iMycyTuf1wpt9Ssd4N69tOf2mgcf8WRXZcI0xhBAKOgwWBpCl9IDeXxwThiYUh88PvihUB1NxyMaw6OwA2YM5r69zJUSEyR9tC93v11dOViU2389Kqa0RvOolPbcLC1UKn\\\\\\\\\\\\\\\/ZH02heGtCFklQmo0SPI+QYQMQcq2wjgbIrw3rGSWCFgcys8P1uFI7IFo8vpPwn66f44Kc65vP51OW7kEHilewsmIVSOszyd0500ZmGxf7z0B5b1k1NPAwYw\\\\\\\\\\\\\\\/L8EfS35lpZMjmBP4P9Hf54ox\\\\\\\\\\\\\\\/aTP6rqZpCI\\\\\\\\\\\\\\\/SzKrbjVGTqLp9UBI4qht5zOo8nRQGnAYlI5zG5s\\\\\\\\\\\\\\\/xJv3CpFE\\\\\\\\\\\\\\\/gs9b93d5iCT6lnH3ptVHStXatc2DUwdifx6fyQGazijGnTG0NUoXtVFEIv6VfEEg18DedDo3s6H9BoXEOVEDLu25pPm7SCf1PhEDPgG5XJe\\\\\\\\\\\\\\\/69LMaiyfvFETBc7bry8q4ePSYyUX9ZalSVTGGE6jaeeRT4O6WThUPaKWm1zZilU73StghYjfW9Ox\\\\\\\\\\\\\\\/dzNitvYAJu5QY4s4RQZ2rTf7sYP7slb\\\\\\\\\\\\\\\/xTkFdCNhMqW\\\\\\\\\\\\\\\/GkAFo1peoF6LIQvjKg431GwjQ3hEqQMwtM2d32GJCjCbm2Lrnwp3OkxZK4a\\\\\\\\\\\\\\\/5xvBaHMTBAg4H3j8Jxg9EfWyl9Mo0qIrqaVW9Y\\\\\\\\\\\\\\\/unqRgbDisCeQvYBrsXPDX55RNw6K8cT6tat\\\\\\\\\\\\\\\/w+\\\\\\\\\\\\\\\/smf0+92g5fx65JuHp2YRUW1AktGLLqzBfu06GsxCUGWEbz9b4CKdZ1TEb55PUt2ybDdbrCyfZm8SKkyvOdGwq\\\\\\\\\\\\\\\/JuewfbrES\\\\\\\\\\\\\\\/vGIT7id14RdAKx+MJwV63zD4XA\\\\\\\\\\\\\\\/dMGRf\\\\\\\\\\\\\\\/Je0xGv5n3UB1fBiWTOTR4ROxdgo20QJZ3qIA9lftaDFSfZMjkvj6MLoL7IqcieW5iclAUuPczH9A6aLeEKqWRcngT\\\\\\\\\\\\\\\/fDLRpoE9iUc\\\\\\\\\\\\\\\/KbSl3\\\\\\\\\\\\\\\/0FQcpfglr0b+L7drPOo\\\\\\\\\\\\\\\/rlfoiCOJ\\\\\\\\\\\\\\\/mXmSGmfskTNfUG\\\\\\\\\\\\\\\/Wsg3MDX8AF99GJ8nWuC5IF4uOFxsqbGDUGMQSBQ\\\\\\\\\\\\\\\/WcUj7bglSRXP3Wr2vylSs6AHGW3KhVxyHXBXFyODzpQQ7wjiihTH+d+uuImiROb47ZPbTgLKsPUKN8iTCh4xhrP6xgondc22FwcNyDG\\\\\\\\\\\\\\\/l7BmQdi0yK1J9ocnmo6zQivkNzZbDVfCsDIbGhY7E5WDfixF6lCLJnJV+rn9UBCcx0hCHlafesDrdBaFLWzJLVRLNgzfadIf\\\\\\\\\\\\\\\/Gpc\\\\\\\\\\\\\\\/lMbfw1u7sUWwfcOga0b0YQyaGuY40Gw5jp8W7F1LFQDgp46Wn94nSzJ5wgZY7aJzWr93+QmMnrdNa8krBosc7y+H+IYGsC157rY0+yJLo60zAyY75+E91ta6cowlYKa03WVIrfkFR09qCnCrDWVS3miOnK2mVFv7g2DZnrpsuSU0mmwGlvrKtnbH3SBWfYfAsEvygEwQq4Z3LokgRIAyByD69A0AVLDpchLPY84JIVVwrcELyjuakYMLicIIm35Yq2Kk3u4wK19lRSTyGgDtVpfHt6regSjzrmnEHV1LryLrB+kYfljV822I4w6zucOCCS\\\\\\\\\\\\\\\/tmZ9GzTNd0TPtj0qqrVn3UeLbRYQllwD9nIK6lTXq7Hws114CGarDvGXxURaaQ6i0n2ozWqHhsZF8AJi6p\\\\\\\\\\\\\\\/dK6zAjp4LcB4vAgb0maiq3ymyWbG7ysT4Tg7WeNfFSXAcozBDj+aU\\\\\\\\\\\\\\\/TS4BOk5bLs7PVTaNhrpg6Ku0WrF7ktSzW6EFVj0fBAvJX3PmHJxkbDhgLLluegQCHA1bpsTD9mTvazrWcRJlVXStdIgtW50zK4LdV0Q1A8t6kN202gljwWwW\\\\\\\\\\\\\\\/5xxQ1kgtPu3uyBoAzIR7Ys4QZOg\\\\\\\\\\\\\\\/R1waMBgmJY0a0w7Sgb0V4oq7UgRBM8giaVAVh93uoGJRxZZOLotYrAaNYJpJ9FsLHROhyCwEKy0rdnKUSCi7kDRPLcoXuAj2xJ9i7uz4f3PRFB64CGGht\\\\\\\\\\\\\\\/Hq737ju7\\\\\\\\\\\\\\\/38BBhK4r+sjWaQw6\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/E+vgsuaSXuKTCvywQanLZK0zrECDr3Dqyl3RVU35B01y8UaB8rOnVspkdvOIq2u5cn1oyRSJiku9++fgKrPqbbMxr\\\\\\\\\\\\\\\/FC6o1bV1ssGG3FQXPzWcaaAAPFMQVhD7RLpE739pxYK9ZmnVt7HIfO6ZlfCnxJXAAaYv1RzZ0IttdaAnzSh5Uqyf+\\\\\\\\\\\\\\\/Q0V4\\\\\\\\\\\\\\\/HuNYWtAUs+Vo3Z2ufSK4kpha\\\\\\\\\\\\\\\/+in14l2dLZHp6UI7QdXR7Thh8d8AlVzkvI\\\\\\\\\\\\\\\/+KEK9u5OW0+FvT93Ze5RyALqk6suDgkpERg\\\\\\\\\\\\\\\/I629ISmog=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00224ZmMPDcmSttg7xY9WQbQAA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022c19c488f6eb757da2826aa5eb19bf4619afb610b9c3b6ab998bd7732d6298c38\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/1\\\/Suppl_1\\\/P48.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/1\\\/Suppl_1\\\/P48.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;1\\\/Suppl_1\\\/P48\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-1-S1-P48\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-1-S1-P48\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-1-S1-P48\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}