{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022n+YdosW0hH7aRRWqse\\\\\\\\\\\\\\\/zYADNksGMGVZW6euRZ11e5qCHokRTrXUEDt37F6s03HkZ5ij9gRys+KWdqcyIbXnhmK4RvRyWlF0le3zTDNn\\\\\\\\\\\\\\\/qgV6rn+NMkcSZl\\\\\\\\\\\\\\\/DCjLxhHWOhMWg3CJydXPP6fZaP6iqoqXoeMzLMoG2gKcSsA+df4DJem1D59n3LjUOrryb6sJs9s0TPXB6\\\\\\\\\\\\\\\/fGuMGFelTUasqMepxGvXNOmFgxHzRGquTLpxXBxXcQppQodYa8Y6bJ6h+ztyL4cOUk0pCqCfpwCIeBFoapKnxQC3zsxIlVrn1Ik1jYZRk+DEonm+\\\\\\\\\\\\\\\/nAbcalVx3EuAQCZXUgMLPx8G8hZES4gNitnZsCSgWse7IgIm3N\\\\\\\\\\\\\\\/I7KPvfteVYqkKlHqsndD76BotEItTxzY7bLT4EbDHvk+jMxUJxRuw2soY+On7yPP\\\\\\\\\\\\\\\/lzMoNsXc7uAOKq\\\\\\\\\\\\\\\/yTZYUH9OfxNdCnlntTMbWc7wfD53ZnA\\\\\\\\\\\\\\\/Wbjh9BFqZ36zGbGH44zvpLBG6hcAiuHditTLMKqVtBJooZeY7RAZEO1U0mU9gq3Uf7Ig6J4sBk1Z59UQJqYM6IZDaQmbLuofUMhQqJ9hRVkhcgoEd4QPRhH\\\\\\\\\\\\\\\/01cPDnN55eUdUi9Jee8o6uwNa1lbV6MRjwXRic\\\\\\\\\\\\\\\/ZBAMV\\\\\\\\\\\\\\\/5kEq1ZqlvIxPEOf9cC28ENEwZ3OdfBRs7ONJMdv9l1g6nXNyDqkYF3xzdxNdk+XxfAxFggdYT\\\\\\\\\\\\\\\/Y6jz2nvn5dQqb8k7gaftuRvSXXHVHOp0KHgN1LnxzyCh1jURQOwS2\\\\\\\\\\\\\\\/8b\\\\\\\\\\\\\\\/2jP7UHGtedEzkY2gx7kqznympIaDYpjINVFA5Bww5\\\\\\\\\\\\\\\/BZwd8+muxJNx2SEXsmRlqr0MVxWhZ5+awjV7fHye9OGdkOBFDGTNfm\\\\\\\\\\\\\\\/3U8lwyF1KLyteKh43gASykwl3e\\\\\\\\\\\\\\\/Yp7WK6JPxEu\\\\\\\\\\\\\\\/lX5MSx7npVLppEFWUTI54dAzxNK\\\\\\\\\\\\\\\/rlMm4mzN3Hup5XCYoHoDmTV5EQjI2Gh\\\\\\\\\\\\\\\/8YzBrOfqJkZaJELWyAqJtuZ9KPGKwWHw\\\\\\\\\\\\\\\/dGB\\\\\\\\\\\\\\\/X6kLTbDUL3QjbfqvkjeC+XIa\\\\\\\\\\\\\\\/JiR\\\\\\\\\\\\\\\/PRgjWNTmDOHNI9HvWc1mzZHsoix+7uk4hHPoW\\\\\\\\\\\\\\\/a\\\\\\\\\\\\\\\/NAdHbu3IVB2OCM+kmNbchuUVDFgCxosn6VYhk4NVEhaD6Kf\\\\\\\\\\\\\\\/tu92KVeCzl+cst8Ny9UvUdj8PrfaTHGZ4KwFymJiqdlvbo86vPEI53rDqQu6YRleBRKlSPXE+pa29WrYXfVgbESfxARbyzmbmJK9KV7RkfXl1vjaNH02SWdL+lv7fRy07IOoVLQvmkK59YHFSsm5SqqBwh\\\\\\\\\\\\\\\/eEeNClHcjR6KQsL3fXdfZoeUsD5FDYoB8roTcQlx\\\\\\\\\\\\\\\/ruirwHh4\\\\\\\\\\\\\\\/JaUoUV4z1CATjuFpv6MPABRAbn+z257Ns12AnYbxfqnwK7SImcvCw15MkEKCAiOcjSHSzicctubt7ldAwTAPg+Q3xWiM\\\\\\\\\\\\\\\/Eljkxj1KFRAGi+qDXqlMJazZLn0jpgcRR2bCpC+plA1ZV2JGxGbfL1GKiJTtvZvudvyIH3Q9503tBQmUnSdKp2HCkd5wwtVh8gdx4qgUuhbd6T9a83Tgsgz0WpOIVOdyQ2nI\\\\\\\\\\\\\\\/dqVOeKBDOWBh7ZmhrAbuZxxy9y3DKy1oYEAVRVrRqBPrnS+GYyrvhrFk89yn1hOXSs3P3fK9Q0tyhYIr87UEpcTDjQEQBMtFhTvS655h2srXzBUfvoWKqM6MrgqhIaR7QuxTtwF4UTDOPinvecbi5W+QvtvwUtD\\\\\\\\\\\\\\\/nbbdmKBr6GRflv4yh4kURerCtT2heq6d8lAdvuVIDEKDvuQInxrmZUYDFMvWB16rcRjrfZ1cviAOh37B28xdBFrWylZoSLj9WrHVGcmaWHC9fWz9oJ4f2Tip3ZZOuBltTgnSEAPC5plFfE\\\\\\\\\\\\\\\/Ph+e6Yfb3ETGgRtYSyAUQ\\\\\\\\\\\\\\\/8hLIfD98UJHl+LZPXd2h93GfuVaMRoKDW9H1xYByGmssRSvFPPZIsrLWReRntVlXGbuzgqfwB3s3uJIJd65SKZDZn9vJ20dxRvOr3mNhYhZaWpCi0nPpX6pdSlJr7hR7uIOwmjd0VBjtPoOuXqpqDTjQflGazIMkJxu59\\\\\\\\\\\\\\\/p3i6xbzp0eLEAi2hNLpaC43QW6XfJ82ZeXSyqwcjnjfuD4dULbfTbqHny\\\\\\\\\\\\\\\/Ft6pXVisUDT0wyj2mxSexuRgQIJ3yzF+LASqHtWS1EBu\\\\\\\\\\\\\\\/YGM7BAx4Ukui705tBxuXk1E5GSqvuVXFMxtvbowe\\\\\\\\\\\\\\\/PPAZhjSpX50pJuqla0dno4ZTfd3xhOIUg0EPuWTWfSVkGFW5qiDt4CiHt1VzGqdPSDWO6LCeg4Pd4jG324NVCHg2MW5JTZstVagQUeRsGKtrsIFlS6SQ4C4dTIAD9c3LxKGQv3ajHM3G5IEmCAxJVus2vJkafE5HO71WZtuFmGXACvWvs\\\\\\\\\\\\\\\/usDHxTpO4XnerfVVPNxF7GAnegfL5FlndOpmlE5JX9RvRRyl+ySAgz9nvyyRXJ3\\\\\\\\\\\\\\\/ni5uWigjKTZ5jR2GHtblhKiBZS2ZhlKxpr2fdl4P8\\\\\\\\\\\\\\\/wx4bJmdUqWTiKEhPU9YnThUY+EDO3o3W\\\\\\\\\\\\\\\/fBQPpB2H0KOVZYchcM428MQ9o5zeSRCY0ElcXOPBFyLctEMUdbz1RHjH7guAQbJf8xuzHDnYj7Sv3ffaH4OhZklOMxHukGbSA=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022l8yiftzUjYPB2eVFMgiKCw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002242d5322a558c2ec298d75888c0e5d797262129cb256666e78bf401df5caa4085\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/5\\\/e008104.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/5\\\/e008104.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008104\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008104\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008104\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}