{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022\\\\\\\\\\\\\\\/qoMACuIXZMyFtz8N0Ad4JOOpY5kqyZzK5kcIbvbzOiyBararsqIvOIqs7+tLjNtG7KVtxybF9QPKVHjYj0\\\\\\\\\\\\\\\/oq\\\\\\\\\\\\\\\/dJuOTZL5sW8XNjzv9bkVV7VWEnJS3nD8OHqZFpfH8l+fY4sdE8mWSoWY9uIC+vktS77yyKD4FqNtpfgakMmoS24UJAHfhkX84uALM\\\\\\\\\\\\\\\/TNiwz7wPUeEH5EVJSEdFRF4Q1HKyTr17+7paHRc632X3tVuh0++fUt+vne\\\\\\\\\\\\\\\/xWF58QwjPthTJvM\\\\\\\\\\\\\\\/zbYMqHrnqX\\\\\\\\\\\\\\\/89ICtPGCgMWpNOq9L\\\\\\\\\\\\\\\/muvpuZGmiZzSkq4Gq5\\\\\\\\\\\\\\\/L72gdNS9nCk9HjfYoi8Dz9w6oG+8CBzpXZ+jpe14Hr4Nael8DJLltDmTP448E8FL\\\\\\\\\\\\\\\/A\\\\\\\\\\\\\\\/6diB7u8QmGztlb14a9UJxhFifbLeLuBPZFrE1kgH5tEhuq286DFHMTjdzlgvbKybhaujgzD+o+n\\\\\\\\\\\\\\\/qLvDHcjgcBkWMzdx6LE5fu2bhQ3M6p5KNc2vUqNQ+W4ZaJV1I\\\\\\\\\\\\\\\/K3cWnUCnCJIshIoFMmeMhW96ZwGg3Swebk9nSGosD59GSwrBMREqpU+eYIkFYSP+JcviDXF47NegQa8zSbAlC64ZuCD8\\\\\\\\\\\\\\\/YVLY2LXMsN22AypU+2NhbmWRnlYeBDyakAmvud5hB1Bu3yZqOvotxKRXueopauesfO6giRqt\\\\\\\\\\\\\\\/fU\\\\\\\\\\\\\\\/LffsdbE94BLiO8IE6\\\\\\\\\\\\\\\/XVfD5GoZ+Vd7jhtPjxz4Q79rimsZXxQysYBiC8HVNb12kAl+jBQvgdfH3rDSQYpQSceyftqHWMCEhkW294WJ3oKuGGwGFo5Q0Oz72cBpm37EBOMuWphFt0nMmB8Vm+om7B\\\\\\\\\\\\\\\/OFJqC4WW3CJceb7cneSDoAPS7D07LXuudRQ4NgEODN6bozDJhKKre5NJsRZ2b+kh\\\\\\\\\\\\\\\/pyl651tH4l114AwfhPxyhbPIewKEEcgmMU964rRQixddd6RzdjMGQNAC\\\\\\\\\\\\\\\/nLjxP1cj5coCU3FOy\\\\\\\\\\\\\\\/zB5PO5F9pMvBeA\\\\\\\\\\\\\\\/KHp5aoa3REfyuVhftk9cCmAWNscp+EIKb9hhHcwUjTrIvVKaHpQL8EuzAYOks9b0+hy5SDzUj0XDQgkgyp9\\\\\\\\\\\\\\\/wGnWE2XCKx5tiNAjY+VtET8DyAPJUJJJQl77Ck+dcvcOieeAV2BXDEIRVKoTlnagXOotlmkIE3WlQoxHSuU9aCS5BUk7otkrwxt++9EER0LhiO5Cj6aFBQIGQd03H0RpP85B0rRskKLpaArkgAevWfSZqlW30z4Nm4xI8\\\\\\\\\\\\\\\/HRDmU6iHLuOzoQ+8W6KxP+1o82ncJoP8EWhqCcmNDAkrTC7Vq5E+yD0MLoYnVBAG5PyaNh3zg+Wg6WmZqbNbxlB5RGWzNXE3EVUo3gu3oahYJU7hAK3LRv622vO+nMB0k48iPETIpeaQGpb1quQniJyv+O5KuRwMVi9qZd1ZBUkhoCUej2UhzQc9wFc54z1EbtEr3oDSfIutX4S2UbLL1p5cQLtOMTNtwhPh5lubl3DVVdJBBax78CIfN1IuwiUJEHtVr\\\\\\\\\\\\\\\/RuT4gIl6lQPDOtZ+YtlqaI7FXVK1Qd8Ejnefjj23edZfJ2jUWXjSwg0t\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/pMRvRUz4VMohZsDpCE78QCt382uOWfHkKKJN\\\\\\\\\\\\\\\/60dWnuFf0RDdhrbPqu1REtyvNGrsw2tg8RXPDA5t\\\\\\\\\\\\\\\/a\\\\\\\\\\\\\\\/++vJfdGwhaL4tq+cpFs1KA\\\\\\\\\\\\\\\/ChcJo+6yDHhBTd3h8pPwaRBUgbZO5cbdBHx5cmx8WQzqv+GVhb1dv5ZyRtlXF40SNRpVuVDq9MmGqR+xMunx9J2f\\\\\\\\\\\\\\\/CqRuORSAKkfHjWD5BE8leLFhKiO5zTjiule+YDmfkPscE8AIcyTUCGmZr6seFdUr\\\\\\\\\\\\\\\/C\\\\\\\\\\\\\\\/a7gU8PNZyfKKxI8eK9eJIoNV1HcFbUUB10+dmGIMTFIeGEk+BcbouG\\\\\\\\\\\\\\\/atm3qs2nFqYsKfCSRdlorg6kuiIIDj37KjatRiQ4fGgPCaYy6ZJp9kM8sMrL\\\\\\\\\\\\\\\/GTmPlQ7nGWyPU5tnP5WoJwtjvdYMUJkpQOVU6LPeYhSOa5GBtqA0iv2HITc626m\\\\\\\\\\\\\\\/hoitsEpCpMXXTNasa6oBLGQVLr5yluIY1qgtUGkLkJxWuv2NuRGPs8xW3mR6wY1DF\\\\\\\\\\\\\\\/BNDPm426NZsTttO43hl3f1xX22ehfj2PT0TUd6ZPbKG4b3gdu4zxZ77LzCfcu6agzFvkVlQJXD3JGbyySEpSSOAISZzPS4T6+EtycOYwcJmzG3sVk+9dQ0rUvRwqRGA9g9aVLMtp2eQvHAscTu2YxXQ8E24ogXksWPHby+OTVf0N23WHG9fWcx8Ktlk8QWYmecTZV\\\\\\\\\\\\\\\/ta90ePuQLRtgshi+mOSEdS60Jh9AT\\\\\\\\\\\\\\\/nO7ebv6kLDm90xBlVJMUcM8bUtdwEkdUgi\\\\\\\\\\\\\\\/E6mb7tLXuVDzyWo+62SI4vDSVKUiMLlgy9rFqh4HaX0KRyaunVmk+7+WyU8k7aH5ztT7Sqd02A6wYihFOjInfi3uCp502CO3bckZ9RK6mxn4wjEQZqOB\\\\\\\\\\\\\\\/eGQuE3VBNeHavhwMRsxdDCpvOzMpsxDYjI6Lfm2apsxU\\\\\\\\\\\\\\\/XA88gyxGUo5T8lwGK1Tjcxo\\\\\\\\\\\\\\\/vnHoiLi3bL2AuZZV8B7Oz0zB3kfqyNt8yuaWOVMEOkHhvB+s8Bo8A1g2taQZAWa6VQiWCsueecR4tgOBbucHpYFt0LtK5B8YlsL5Y=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022fW0ldWaA+tlDHRX\\\\\\\\\\\\\\\/i3jINw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002207b95a1e8383a6c02a5151a91022e0c85fcd4a13f4bf86a5aaa61c64883ca634\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/5\\\/e008662.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/5\\\/e008662.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008662\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008662\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008662\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}