{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022FmU2ZpnHJ1aBgpkhftcZEhOjGBTmzujtBSwpHfTg+cfS0tBGutMWHcuODtMTxmdnU90J0VW459yIcuhTViqzJ1Cn4JDoXzm9dhyRm0sobs35aqry0Y4ZrIVCnBqdMrZ1kLOE7SPCg+Yi7V1O4q1IXF7XwU2Pk6LAjbd5ztnBE9f56U3BMtrCgWEPMfx7mhkpYYmn3vUpWhL7P1F+pcgkBYsP1Pb5OHcRIa7TiPdLjtbVh40fy9l5ElzK+GYbIp1bvn4A\\\\\\\\\\\\\\\/b67gNDxbhOMGgXCKWPKaKGVqaj3IkZmcMwgPiypw\\\\\\\\\\\\\\\/MvHnurYZFO6y19n5fwltnj00r\\\\\\\\\\\\\\\/CXGZaIm2BVEbdlLk+mgqS248jmAWO\\\\\\\\\\\\\\\/OJSdAKTrApXlGnu1Dngha6LGkrH1qjepRbEdZpqTphZP\\\\\\\\\\\\\\\/WUC1QOgco5JH\\\\\\\\\\\\\\\/rryIHkp2Q5XU3KkhjvVAsRCkRFIOi7GmFSv2\\\\\\\\\\\\\\\/uDFXtt3PUw8uNiEdQTptTfzin+aNUvJoQuGZjhmGDRJM6X9k61p9UxmPNcMvwGCa9urSxEEIa+nbpCqMea6B5oyaN\\\\\\\\\\\\\\\/wlrw309fOBzPTJuPjBTQ4RcMcwNLRe6BWs0EKxpxyPdoO3dtIg9zmFwfM05mCjQQBCuZEU8zRorZOy9mgC6CuQTinrcc4GpL7NPb\\\\\\\\\\\\\\\/WFn4ZUrDjq99Imf4saWTJ14Hv\\\\\\\\\\\\\\\/7PfRuRHBOvXJ62P\\\\\\\\\\\\\\\/IGomWrtSQce44\\\\\\\\\\\\\\\/MYBPJKNqyGBFLx6hqjejtoIBVwMTs0RpMJCwQuUiivdoWgJC5\\\\\\\\\\\\\\\/BccgIb5VeZYuTnOrjJi9S\\\\\\\\\\\\\\\/jX0rAGtEu0QJhaf49lzRE\\\\\\\\\\\\\\\/mnKrmzbHPdCMKy7iSmbaUDT+T2QpTlLf2A+cqT3LvHPIwUgJMv+8HMDj2REIWCUbW8KP1XDIQNaVXRJp3+OMemVtE8ixq9nSDCgb2jXX0lK6Xxo18mwN2WLfMe8Wt6wkoXLRnfrZ1hlvZXiqcIbV1\\\\\\\\\\\\\\\/K1YehwbCRlubACkgwA7mS3so+hrrtRYRPi4O\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/3TBkhkLwUjLX4yhQZTI41gtSxblBaU1416\\\\\\\\\\\\\\\/G8WC0YfAR8FZLhMddVQPu8o6e\\\\\\\\\\\\\\\/WOHNME2nJce0JNV7AoikCw1R5Qh2SESwAUY4IR0Fgc03nACfSc1vX9yUFLZdGF1WVbSRnWaJ8aiGgrUiX\\\\\\\\\\\\\\\/iCjt7jFbFNmT\\\\\\\\\\\\\\\/9Ju3pPFuv0h7OgZJXUnYQcEF8JsICRnR\\\\\\\\\\\\\\\/5YP2Xms\\\\\\\\\\\\\\\/97s5ATgl\\\\\\\\\\\\\\\/octyeKWMux1u\\\\\\\\\\\\\\\/ROdctK5PMFA2sbil4FIOM3VQrO\\\\\\\\\\\\\\\/YYyuQmvxkWfhSVYldcfd+a94j\\\\\\\\\\\\\\\/6JQb+LdhGIl1ol8hyd5QfAdwKNTzMhPoz6xWUl+4zDxWELVgdtwxR1vnvRAXddBW6JlnapqCb\\\\\\\\\\\\\\\/xB21uwc1oQ7tThoeObo2TGubUP8d9yJAfWwhIftlY\\\\\\\\\\\\\\\/KTrg2qqjrzd+tVQ9TFQpggbgavs93gFgZjMfBvf2Xs8cEVrd+rnfvM2qLCWpaOVQE8L\\\\\\\\\\\\\\\/VmmqMmXR7cTIfQ90ByKKP1AgnskdI5WZ2SqYGemWgKNjmDR\\\\\\\\\\\\\\\/mQqvxg3a5Wn6Vv8V2vZDqgbXV6GOX8+ELP8tvR4nJxz6uuQ6ROf7WSCpEawQsVb89q+m42qcigpeC5\\\\\\\\\\\\\\\/LpxCVt2s5LtmfJoE3\\\\\\\\\\\\\\\/UoZH94OrRDPWTYj1O41J9HPXsHV0sU8S6jqE4ovWRgZyczE3XEWzii\\\\\\\\\\\\\\\/CICv0GypCXqvwuFsvM2aPoad8Qc3j8K3LtAeA+oDVruYEKlxpT5It5bKenluptAaunjl0vP3Ypu1Mye0F\\\\\\\\\\\\\\\/nBidxSMuhDcdoO1vmTgJLvLAcQsaiH0PaTQSxw7Wjg9WvI\\\\\\\\\\\\\\\/VwMviKTYRgdpfz0olMfcMePdGV+ysOt9ou1NCoKlitzs4Pdr4wVAFIgADH8ULpyB6SHO6bZNF58Na+q4azcTHaURJasyROzE\\\\\\\\\\\\\\\/t2dfKv9d5VBLUuvGu1Wtfli5sIpph+uCB5JlhaLavzMPlK8Nj50Jpx9\\\\\\\\\\\\\\\/aZ2Jntn7zMVNz2Vl\\\\\\\\\\\\\\\/U8Z26IRj3npg18zMG+CLBvqqzol4XUdGihYfAH\\\\\\\\\\\\\\\/tvmHz+DJeZB4urPDu8VnE2R2yTK9vInKNhpuA2JkLRpM2bsKGZpGNnSvushBZpem337X1ua5xr5kJkj6RROJpnbkfPQI1qfzBQXlWbMyRY+K\\\\\\\\\\\\\\\/RIy1c3YlRvsBJOoOpqYIjzZvSL8xUXaJ\\\\\\\\\\\\\\\/mc2k19RMBh8bgXRKOUaANzocNTyKvewmbGzI4Fe9orzSaJiQAYmc7AAwgZfo+2SkaS+ei184mmPdTJboT3LBFzjZwlEcp055uAD0jNhNBjuE9yjyEneOzMiN36dC9WPK+FEewYVu68s+uqAGljB1+ME9XfwZHxwEP2uwIcLetdDgejixzC2ZH7HrYRiS\\\\\\\\\\\\\\\/YIDWjBe93zmuoyUiJBH2QfdOWGp7AcPesgU4XJ6kjc9nGyE5Jvh1\\\\\\\\\\\\\\\/Us2K04dMeE7cLUo+Peic0dD8Za023tX4oRD7QFSv1kImiGh3W07mxusrobl8atsvp7GjZYEFixiCITM\\\\\\\\\\\\\\\/I7KRe1x\\\\\\\\\\\\\\\/GHnWxlWj+ZXTS7AvFOKsmVXqVVzSEVSBaBW6Sn6LOKKamOfU\\\\\\\\\\\\\\\/NPz\\\\\\\\\\\\\\\/0rJtRwapwTRwcqZj7yGNTlokqBAreEhWSwps3xxXvqli2D+9lVK7f2cxFSW341lAFH3azc4ZETA3tnbt9K5SqDkCWsJdEHqBZ0QhlU=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00225DOcdf\\\\\\\\\\\\\\\/9PXSL27Nhyi\\\\\\\\\\\\\\\/Nxg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022053005d1bca51a5be2b9180c46ca90eb41f1c21dbddeda045fd5adbeb00d3577\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/4\\\/e008967.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/4\\\/e008967.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2024-008967\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2024-008967\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2024-008967\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}