{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022EGPAVUa93Xk8aIJ3TvLRLjWzyWeFrlT4MMDz\\\\\\\\\\\\\\\/IF98naY+opacK4EbAbmikBAYC31qQyLHqotaI8B+nE+QX1+JeXDfd5HSZ+Dx2njzTh\\\\\\\\\\\\\\\/B5sS+\\\\\\\\\\\\\\\/FlRsnjD4BJ84WdFUTe\\\\\\\\\\\\\\\/CY7chhsjRvabars90Ayax5oTHU0EXogD7P6YWNprUtHbh26pwcF4YDUzeFrfRgNUGT\\\\\\\\\\\\\\\/PrJp9cx6aj\\\\\\\\\\\\\\\/UroPneihpF+faqt2X3NP7WzvtxUl3Wny1emXwK5QSaEAMIoQ4qVY5zRD80RVdV4US\\\\\\\\\\\\\\\/mdODQJIxM40AVH5PjPBIz0byFDiQKWhc50SgbEaHrNpVc4SNtSaFYvUjcX0wnXE1iOACEd6KA8GjLWFXRbcYlCCEGfmsNqxCL\\\\\\\\\\\\\\\/noIDLtqSDbu7do3w17JR1KXP0TY6+P8fuI1SpDfgtVkRJf91lRbvp5dWtE5qSMFskDYyWFfygHem\\\\\\\\\\\\\\\/OqFkEjYs9kjOSJAt9RgKxMB0bFWAQ\\\\\\\\\\\\\\\/JGK7vMCwR4U\\\\\\\\\\\\\\\/95pmuaSzDz9N5bR06d9973n9GGBqTq\\\\\\\\\\\\\\\/EGeBDFbqIIyNQqkjExRrQEOTsQcHcneLHvD\\\\\\\\\\\\\\\/DftwHWAtZF\\\\\\\\\\\\\\\/eWT5\\\\\\\\\\\\\\\/fqlTazsZMENxS4WsQl2BlDnsDsBQZcSUd+SFJne+Wk0yK\\\\\\\\\\\\\\\/QRMlhz1VHjzF\\\\\\\\\\\\\\\/pQ3GNDqpxRHNY2HI9QXOdpPPK2\\\\\\\\\\\\\\\/XF+DMnwMVFYnwE\\\\\\\\\\\\\\\/PPkk4I6rtiG6P96QhUnFa9R5RLVJ7XIF0HSX6TS\\\\\\\\\\\\\\\/BaqVw8H5B4QuL9dTwVVWlwsbnx6B7gLEwKpE2PS5zsLNj8xNM58BJpyQIAfdQ6Z\\\\\\\\\\\\\\\/eo+JhXrak6z82ceuqPSa3CxdL+\\\\\\\\\\\\\\\/o\\\\\\\\\\\\\\\/xNXCtqghfRqIEY8ZTcQelpvWr7coKCEV1GsWTI2khpg\\\\\\\\\\\\\\\/zsetsD+M4Ruirl3xCQ2m7\\\\\\\\\\\\\\\/DnLcHDZyOlusz0Mx7IG6FpAsfRFG6TSodqOnxP6i5UwBA7fG6qJBFYU0m1lPJ8akZ76SJy+g1oFb0U1wUe93cAyhEvnSWgHmuwW02fh4wUNban9IqmPxpLfGLLpZNjssG\\\\\\\\\\\\\\\/GffF0wjVecQE1PdnISk+WtM74GqDi1A3+soY3Y6OXhUYt3Xou0IuyEBLqHuO5YSuxR\\\\\\\\\\\\\\\/A3qOUTLCj\\\\\\\\\\\\\\\/CoZRfk1k+x6HnepOhcohyOgJAVNSSctSfRCMIefU+nmmkaY6S0jAApAusUsicxh09\\\\\\\\\\\\\\\/7ZgaOOE5x\\\\\\\\\\\\\\\/aOn7\\\\\\\\\\\\\\\/nOmhWo3ThnSlxec37Q1WpiM2X71VNehVXYc8Gn1adNI12avRfHLD2jyFiDAElQfy\\\\\\\\\\\\\\\/8yRpyrK+q5qONZHcrAcLCdhDCrInfFNu9sq8hqK8y9f4CSYO9\\\\\\\\\\\\\\\/4\\\\\\\\\\\\\\\/+dC9FJA1DkgHKLB+jwc94RpmU6bWkKpBBDzykKVcNMwhtAp68GZh2MhPFfIFRxA2gbLrbdsg5rHhYAxukzyot4WEpTfU8sCJC5q\\\\\\\\\\\\\\\/bn3m66tEaoo+4wY32DOdsvA0bB+TW5KbXwR6UzciiSNtm0BZvImcoHv7zvwe7KJt5Y6UaYx73OAHWBAqyKnQb+R1CYiWrOOASPomlJXNLJrAU6hZbFIQt4tA8X0a+bA1YnLRHXvrVQdRqGYykROzLWA66K5jXfP49hQzY+i400WKFfiFe5UfjjESZ7FPUuICknqdRzHu\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/YtaHlCcoxsylaQYFumJdbL1nWRtdX1aGpgFuxbPAt8bhdKJyV4DOpWTF03aAymEyqbgoiftGbKv68gAd+7IKuXi2cpXBDqB1Z7HZSgIcDBb3hmBKqcbH0JREB1bepok474NexchXZPsAYlMjeoLYWcpIqWxEZ1Ew6iGqAoV+EQjw8j3uwtmW5G\\\\\\\\\\\\\\\/7hC+cVXewYS0eQLk7ZiWqeDiS7FMz+c2yp\\\\\\\\\\\\\\\/g\\\\\\\\\\\\\\\/9P0UupiBLJfv+jScfLYZpL3qUVWWGzPromseO2lWa9iQeHAfbAAO2CPe9kHbGMinnmgIEI+V6GIhsx8m2ZWshNwRBW51KLwskoNc0QFCabRRwT7zxCc1s8d2J0SJdvh1JEzCayL+Jnh167Vfd3GfHCzgTWvKFRYS4dTcmCtT99j+fNbpao3dRlzX2TBNTOrYaa0rxoqdSlBdYCHDdBL6JfZKhS+uVgwmHCqCt2oWkvmWWl1qN5Z\\\\\\\\\\\\\\\/U7RjDVRlxxtlpE3L1pskr2G8n7jFaHhsTdAX6A2TJt2vVs+L64yYpjKWVC\\\\\\\\\\\\\\\/yZksMuMu\\\\\\\\\\\\\\\/OCsiUKkRT9vKW+T9CPFdqhc42uEBRFtKtEsoPVgcLCajFcp\\\\\\\\\\\\\\\/KC62aR+N4r9Vo5z5I1KRQsYDgkDxScJNcmy5h3K19nxrH3YY4ba1qzWcAARMPueLOT0Cz7\\\\\\\\\\\\\\\/eTkRL3xeQaDxSWLkQzXjJCTD2a0kPk4veiCRPMOAehvztlYUA8stvoPQcPFbGEpSgR9ExgJEjF1\\\\\\\\\\\\\\\/RLBuSRNsDUWz3JJntkp3gJMRtneVRv7WqzSrMRBUbORJn6IH3rp2M2XwlZ43OWnuCyKRoKWR+fe\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/AkCRu2jSHvc4j7s1eMa+dHkCuRfi\\\\\\\\\\\\\\\/pwpN9JHys3wnzjTP02\\\\\\\\\\\\\\\/wXspVPHw9v03yqxd2ow2Sr4UCaiohVIniuSRWsU9AYLpnMjEPVoYUNyLn\\\\\\\\\\\\\\\/rVfwAu\\\\\\\\\\\\\\\/bS9jt4z12Oy88oX75fjPqZu5BzTb2L7SBGJY1Fj6wa5qeMObZQNsj9LpTTHrRMtrZwVLhkNxpFutJR0vA19BtVnB5ew01WIvNgGq666y4U=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022I8gP+ja2hiQArmd6QeVfRw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022df28640efb7b14a55604265aaea282f34eb5597773a0abdc1dda8d0c0f335251\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/12\\\/4\\\/e008656.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/12\\\/4\\\/e008656.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008656\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008656\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008656\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}